ID   RLPA_RICFE              Reviewed;         228 AA.
AC   Q4ULW1;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 2.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Endolytic peptidoglycan transglycosylase RlpA {ECO:0000255|HAMAP-Rule:MF_02071};
DE            EC=4.2.2.- {ECO:0000255|HAMAP-Rule:MF_02071};
DE   Flags: Precursor;
GN   Name=rlpA {ECO:0000255|HAMAP-Rule:MF_02071}; OrderedLocusNames=RF_0611;
OS   Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=315456;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-1525 / URRWXCal2;
RX   PubMed=15984913; DOI=10.1371/journal.pbio.0030248;
RA   Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E.,
RA   Parinello H., Claverie J.-M., Raoult D.;
RT   "The genome sequence of Rickettsia felis identifies the first putative
RT   conjugative plasmid in an obligate intracellular parasite.";
RL   PLoS Biol. 3:1-12(2005).
CC   -!- FUNCTION: Lytic transglycosylase with a strong preference for naked
CC       glycan strands that lack stem peptides. {ECO:0000255|HAMAP-
CC       Rule:MF_02071}.
CC   -!- SIMILARITY: Belongs to the RlpA family. {ECO:0000255|HAMAP-
CC       Rule:MF_02071}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAY61462.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000053; AAY61462.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_039594969.1; NC_007109.1.
DR   AlphaFoldDB; Q4ULW1; -.
DR   SMR; Q4ULW1; -.
DR   STRING; 315456.RF_0611; -.
DR   EnsemblBacteria; AAY61462; AAY61462; RF_0611.
DR   KEGG; rfe:RF_0611; -.
DR   eggNOG; COG0797; Bacteria.
DR   HOGENOM; CLU_042923_6_1_5; -.
DR   OrthoDB; 2027419at2; -.
DR   Proteomes; UP000008548; Chromosome.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008932; F:lytic endotransglycosylase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0000270; P:peptidoglycan metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.40.40.10; -; 1.
DR   HAMAP; MF_02071; RlpA; 1.
DR   InterPro; IPR034718; RlpA.
DR   InterPro; IPR009009; RlpA-like_DPBB.
DR   InterPro; IPR036908; RlpA-like_sf.
DR   InterPro; IPR012997; RplA.
DR   Pfam; PF03330; DPBB_1; 1.
DR   SUPFAM; SSF50685; SSF50685; 1.
DR   TIGRFAMs; TIGR00413; rlpA; 1.
PE   3: Inferred from homology;
KW   Cell wall biogenesis/degradation; Lyase; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02071"
FT   CHAIN           24..228
FT                   /note="Endolytic peptidoglycan transglycosylase RlpA"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02071"
FT                   /id="PRO_0000280827"
SQ   SEQUENCE   228 AA;  25932 MW;  1B532D20F416FD2E CRC64;
     MIQRHKLIVL IFLLIFCLSG CNTSKRLPYS HKYSYKELSK DDPHNLTYKG HYKVGKNYKI
     KGKTYKPHST KSFTETGYAS WYGGRKDGFH GKKTANGDRF NRNLLTAAHK TLPLPCLVKV
     TNKANNKSVI LMVNDRGPFK KNRIIDVSQK AAEILAFKNQ GITKVKIEYL PNETEKFLKN
     INLKKPQSKT LAKNSKKSSS TKVTKNAKCS VNCHIKLVNL KYKLAVNP