RLPA_RICPR
ID RLPA_RICPR Reviewed; 320 AA.
AC Q9ZDE1;
DT 05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=Endolytic peptidoglycan transglycosylase RlpA {ECO:0000255|HAMAP-Rule:MF_02071};
DE EC=4.2.2.- {ECO:0000255|HAMAP-Rule:MF_02071};
GN Name=rlpA {ECO:0000255|HAMAP-Rule:MF_02071}; OrderedLocusNames=RP390;
OS Rickettsia prowazekii (strain Madrid E).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC Rickettsiaceae; Rickettsieae; Rickettsia; typhus group.
OX NCBI_TaxID=272947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Madrid E;
RX PubMed=9823893; DOI=10.1038/24094;
RA Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T.,
RA Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H.,
RA Kurland C.G.;
RT "The genome sequence of Rickettsia prowazekii and the origin of
RT mitochondria.";
RL Nature 396:133-140(1998).
CC -!- FUNCTION: Lytic transglycosylase with a strong preference for naked
CC glycan strands that lack stem peptides. {ECO:0000255|HAMAP-
CC Rule:MF_02071}.
CC -!- SIMILARITY: Belongs to the RlpA family. {ECO:0000255|HAMAP-
CC Rule:MF_02071}.
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DR EMBL; AJ235271; CAA14847.1; -; Genomic_DNA.
DR PIR; E71696; E71696.
DR RefSeq; NP_220771.1; NC_000963.1.
DR RefSeq; WP_010886281.1; NC_000963.1.
DR AlphaFoldDB; Q9ZDE1; -.
DR SMR; Q9ZDE1; -.
DR STRING; 272947.RP390; -.
DR EnsemblBacteria; CAA14847; CAA14847; CAA14847.
DR GeneID; 57569515; -.
DR KEGG; rpr:RP390; -.
DR PATRIC; fig|272947.5.peg.402; -.
DR eggNOG; COG0797; Bacteria.
DR HOGENOM; CLU_042923_6_1_5; -.
DR OMA; GKTYKPH; -.
DR Proteomes; UP000002480; Chromosome.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0008932; F:lytic endotransglycosylase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR GO; GO:0000270; P:peptidoglycan metabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 2.40.40.10; -; 1.
DR HAMAP; MF_02071; RlpA; 1.
DR InterPro; IPR034718; RlpA.
DR InterPro; IPR009009; RlpA-like_DPBB.
DR InterPro; IPR036908; RlpA-like_sf.
DR InterPro; IPR022438; RPE5.
DR InterPro; IPR012997; RplA.
DR Pfam; PF03330; DPBB_1; 1.
DR SUPFAM; SSF50685; SSF50685; 1.
DR TIGRFAMs; TIGR00413; rlpA; 1.
DR TIGRFAMs; TIGR03776; RPE5; 1.
PE 3: Inferred from homology;
KW Cell wall biogenesis/degradation; Lyase; Reference proteome.
FT CHAIN 1..320
FT /note="Endolytic peptidoglycan transglycosylase RlpA"
FT /id="PRO_0000190006"
SQ SEQUENCE 320 AA; 37353 MW; DBBB0B1EF6B8B34A CRC64;
MIIMRNYKFK LEPLKQCQEA FKRYTVHSTA LYIIALQANW SRRLIYKLSL YFCKIKNCYT
TFKFEQSNRF IITKAERIIK IQHLIRFKDI VNNFISLINI LLVLIFCINL SGCNASKKLS
YSNKYSYKEL SKDDPHNLTY IGHYKVGKNY KIKGKIYKPH TPKYFTETGY ASWYGGRKDG
FHGKTTANGD RFNRNLLTAA HKTLPLPCLV KVTNKVNNKS VILMVNDRGP FKKNRIIDVS
QKAAEILAFK NQGVTKVRIE YLPNETEKFL KKINLKKPEN KTFAKNHKKS LFTQITKNNQ
CSINCHIKLV NLKYKLAVNP