ID   RLR07_PLAHL             Reviewed;         325 AA.
AC   A0A0P1AAU8;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   20-JAN-2016, sequence version 1.
DT   25-MAY-2022, entry version 25.
DE   RecName: Full=Secreted RxLR effector protein RXLR-C07 {ECO:0000303|PubMed:30422341};
DE   Flags: Precursor;
GN   Name=RXLR-C07 {ECO:0000303|PubMed:30422341};
OS   Plasmopara halstedii (Downy mildew of sunflower).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Plasmopara.
OX   NCBI_TaxID=4781;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=26438312; DOI=10.1186/s12864-015-1904-7;
RA   Sharma R., Xia X., Cano L.M., Evangelisti E., Kemen E., Judelson H.,
RA   Oome S., Sambles C., van den Hoogen D.J., Kitner M., Klein J., Meijer H.J.,
RA   Spring O., Win J., Zipper R., Bode H.B., Govers F., Kamoun S.,
RA   Schornack S., Studholme D.J., Van den Ackerveken G., Thines M.;
RT   "Genome analyses of the sunflower pathogen Plasmopara halstedii provide
RT   insights into effector evolution in downy mildews and Phytophthora.";
RL   BMC Genomics 16:741-741(2015).
RN   [2]
RP   DOMAIN, INDUCTION, FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=30422341; DOI=10.1111/tpj.14157;
RA   Pecrix Y., Buendia L., Penouilh-Suzette C., Marechaux M., Legrand L.,
RA   Bouchez O., Rengel D., Gouzy J., Cottret L., Vear F., Godiard L.;
RT   "Sunflower resistance to multiple downy mildew pathotypes revealed by
RT   recognition of conserved effectors of the oomycete Plasmopara halstedii.";
RL   Plant J. 97:730-748(2019).
CC   -!- FUNCTION: Secreted effector that suppresses pattern-triggered immunity
CC       (PTI) in plant host. {ECO:0000269|PubMed:30422341}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:30422341}. Host
CC       cytoplasm {ECO:0000269|PubMed:30422341}. Host nucleus
CC       {ECO:0000269|PubMed:30422341}. Host nucleus, host nucleolus
CC       {ECO:0000269|PubMed:30422341}.
CC   -!- INDUCTION: Expression is up-regulated during plant colonization, 3 days
CC       after infection. {ECO:0000269|PubMed:30422341}.
CC   -!- DOMAIN: The RxLR-dEER motif acts to carry the protein into the host
CC       cell cytoplasm through binding to cell surface phosphatidylinositol-3-
CC       phosphate. {ECO:0000305|PubMed:30422341}.
CC   -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR   EMBL; CCYD01000291; CEG37861.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0P1AAU8; -.
DR   SMR; A0A0P1AAU8; -.
DR   EnsemblProtists; CEG37861; CEG37861; CEG37861.
DR   OMA; VTHEAYI; -.
DR   OrthoDB; 992218at2759; -.
DR   Proteomes; UP000054928; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   SMART; SM00028; TPR; 5.
DR   SUPFAM; SSF48452; SSF48452; 2.
PE   2: Evidence at transcript level;
KW   Host cytoplasm; Host nucleus; Reference proteome; Repeat; Secreted; Signal;
KW   TPR repeat; Virulence.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..325
FT                   /note="Secreted RxLR effector protein RXLR-C07"
FT                   /id="PRO_5006058518"
FT   REPEAT          37..75
FT                   /note="TPR 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00339"
FT   REPEAT          92..125
FT                   /note="TPR 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00339"
FT   REPEAT          134..167
FT                   /note="TPR 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00339"
FT   REPEAT          218..251
FT                   /note="TPR 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00339"
FT   REPEAT          260..293
FT                   /note="TPR 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00339"
FT   MOTIF           37..75
FT                   /note="RxLR-dEER"
FT                   /evidence="ECO:0000305|PubMed:30422341"
SQ   SEQUENCE   325 AA;  36122 MW;  2DC7E90E07D496AD CRC64;
     MQGVRITILW CIVLATIYAE EGPSTPRDDD PVIQKVRGLR NAGMKANDER MFKDAIEKLR
     HAISLLHNRV FGEERAAIKD PTVISQDAAL YAQILNDYGS VLIRTKQYDE AIEVLEDSVA
     MIEKIYGDSH PSLGLSLRSL ADAYMEKKAF KSAIKRYKTL RKHVKKGLGM THEAYIEASL
     KIAEGYKKLN KKDTSRKVLK DTLKAQGGEI NGLTIGIAEL YMELSSAHVE VGEIDDALRA
     AETASAIFLQ REGKDTMAYA FSLNALAGVK MQQKKVDEAI DLLDRAHNIA VSIYGENDRI
     TLASAKTLQD VKDHKMNLLA AKDEL