ID   RLR12_PLAVT             Reviewed;         404 AA.
AC   P0CU96;
DT   18-SEP-2019, integrated into UniProtKB/Swiss-Prot.
DT   18-SEP-2019, sequence version 1.
DT   25-MAY-2022, entry version 9.
DE   RecName: Full=Secreted RxLR effector protein 12 {ECO:0000303|PubMed:29706971};
DE   Flags: Precursor;
GN   Name=RXLR12 {ECO:0000303|PubMed:29706971};
OS   Plasmopara viticola (Downy mildew of grapevine) (Botrytis viticola).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Plasmopara.
OX   NCBI_TaxID=143451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], DOMAIN, FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=29706971; DOI=10.3389/fpls.2018.00286;
RA   Liu Y., Lan X., Song S., Yin L., Dry I.B., Qu J., Xiang J., Lu J.;
RT   "In planta functional analysis and subcellular localization of the oomycete
RT   pathogen Plasmopara viticola candidate RXLR effector repertoire.";
RL   Front. Plant Sci. 9:286-286(2018).
CC   -!- FUNCTION: Secreted effector that completely suppresses the host cell
CC       death induced by cell death-inducing proteins.
CC       {ECO:0000269|PubMed:29706971}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:29706971}. Host cell
CC       {ECO:0000305|PubMed:29706971}.
CC   -!- DOMAIN: The RxLR-dEER motif acts to carry the protein into the host
CC       cell cytoplasm through binding to cell surface phosphatidylinositol-3-
CC       phosphate. {ECO:0000305|PubMed:29706971}.
CC   -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR   AlphaFoldDB; P0CU96; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0043657; C:host cell; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Secreted; Signal; Virulence.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..404
FT                   /note="Secreted RxLR effector protein 12"
FT                   /id="PRO_0000447905"
FT   MOTIF           48..65
FT                   /note="RxLR-dEER"
FT                   /evidence="ECO:0000305|PubMed:29706971"
SQ   SEQUENCE   404 AA;  44881 MW;  91B36CBEC60351AC CRC64;
     MRGAYYVITA LLVVASSEIS ADSGHQLQVY DHDVVAAENA AAKTLPQRFL RGSRNVPDDL
     AHEERAITSE LVEEGAKLIP RAAEDVEEIS RVAEAVGKRP HVAEEDVLNK ASGANEAFKK
     PRNTATDDAF QGITTKQLLP LSYKQWDTEI KSMRIPKPEK YQENIQSVHD AFVDVCDEDL
     KPTISETARL WNLFDRSFKP LTTRLHQHAL TQYAKEYVLR DELRIETESA RSNEKTMSTS
     ASMLNLVLNW YFQRWVRMYN IFGKHRSELI DTPSKVARSR GGTTGTSRGT ALHKHLNVPL
     NAASTSKDKS SVLTFKSQRT FDGNPKQSKV QNSELVKPVF TKSAISDDHP VFSKNLKLSS
     EGPSAAFAPY RSGDNSVSTK NSKVGVGGTN SAFVPYKPPS VPIF