ID   RLR14_PLAVT             Reviewed;         312 AA.
AC   P0CU97;
DT   18-SEP-2019, integrated into UniProtKB/Swiss-Prot.
DT   18-SEP-2019, sequence version 1.
DT   25-MAY-2022, entry version 8.
DE   RecName: Full=Secreted RxLR effector protein 14 {ECO:0000303|PubMed:29706971};
DE   Flags: Precursor;
GN   Name=RXLR14 {ECO:0000303|PubMed:29706971};
OS   Plasmopara viticola (Downy mildew of grapevine) (Botrytis viticola).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Plasmopara.
OX   NCBI_TaxID=143451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], DOMAIN, FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=29706971; DOI=10.3389/fpls.2018.00286;
RA   Liu Y., Lan X., Song S., Yin L., Dry I.B., Qu J., Xiang J., Lu J.;
RT   "In planta functional analysis and subcellular localization of the oomycete
RT   pathogen Plasmopara viticola candidate RXLR effector repertoire.";
RL   Front. Plant Sci. 9:286-286(2018).
CC   -!- FUNCTION: Secreted effector that completely suppresses the host cell
CC       death induced by cell death-inducing proteins.
CC       {ECO:0000269|PubMed:29706971}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:29706971}. Host
CC       nucleus {ECO:0000269|PubMed:29706971}.
CC   -!- DOMAIN: The RxLR-dEER motif acts to carry the protein into the host
CC       cell cytoplasm through binding to cell surface phosphatidylinositol-3-
CC       phosphate. {ECO:0000305|PubMed:29706971}.
CC   -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR   AlphaFoldDB; P0CU97; -.
DR   SMR; P0CU97; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Host nucleus; Secreted; Signal; Virulence.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..312
FT                   /note="Secreted RxLR effector protein 14"
FT                   /id="PRO_0000447906"
FT   MOTIF           46..61
FT                   /note="RxLR-dEER"
FT                   /evidence="ECO:0000305|PubMed:29706971"
SQ   SEQUENCE   312 AA;  35476 MW;  68C5DDEE80E96493 CRC64;
     MHSFKLLLAL IVAICTSCDA VPRGSLSDES NFKSYPVAQY EAANHRLLRA KDGKVRADEE
     RLSSNPDSML TRIKSFVNPG PFHELVRTAT AIAERLKETV HSTLDHWLTI QRFNHLLGHC
     DHDSMDSAIV RGFHPSEFRV WLDLKSPLAT EVVDSLDEWP KSTQLQSLLK FIKHYHSLLL
     PPPNHWAKVR ASINPSHASS KPLFHDVYGI KEALEEMDHI IDQDLSVATM LEQKVSPLLY
     KVALEARELK TGKRIDRSKL NRFIKGYMAQ YPSLDKFESM VNGYAPPGKF RKIPTFKGLD
     DDVINPPKYL NP