ID   RLR18_PLAVT             Reviewed;         106 AA.
AC   H6S3X4;
DT   08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT   08-MAY-2019, sequence version 2.
DT   25-MAY-2022, entry version 16.
DE   RecName: Full=Secreted RxLR effector protein 18 {ECO:0000303|PubMed:29706971};
DE   Flags: Precursor;
OS   Plasmopara viticola (Downy mildew of grapevine) (Botrytis viticola).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Plasmopara.
OX   NCBI_TaxID=143451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=29706971; DOI=10.3389/fpls.2018.00286;
RA   Liu Y., Lan X., Song S., Yin L., Dry I.B., Qu J., Xiang J., Lu J.;
RT   "In planta functional analysis and subcellular localization of the oomycete
RT   pathogen Plasmopara viticola candidate RXLR effector repertoire.";
RL   Front. Plant Sci. 9:286-286(2018).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 7-106, INDUCTION, AND SUBCELLULAR LOCATION.
RC   STRAIN=SC;
RX   PubMed=22749169; DOI=10.1016/j.funbio.2012.04.016;
RA   Mestre P., Piron M.C., Merdinoglu D.;
RT   "Identification of effector genes from the phytopathogenic Oomycete
RT   Plasmopara viticola through the analysis of gene expression in germinated
RT   zoospores.";
RL   Fungal Biol. 116:825-835(2012).
RN   [3]
RP   IDENTIFICATION, FUNCTION, INDUCTION, AND DOMAIN.
RX   DOI=10.1016/j.pmpp.2015.05.002;
RA   Yin L., Li X., Xiang J., Qu J., Zhang Y., Dry I.B., Lu J.;
RT   "Characterization of the secretome of Plasmopara viticola by de novo
RT   transcriptome analysis.";
RL   Physiol. Mol. Plant Pathol. 91:1-10(2015).
RN   [4]
RP   INDUCTION.
RX   PubMed=30449350; DOI=10.1016/j.funbio.2018.07.006;
RA   Gomez-Zeledon J., Spring O.;
RT   "Up-regulated RxLR effector genes of Plasmopara viticola in synchronized
RT   host-free stages and infected leaves of hosts with different
RT   susceptibility.";
RL   Fungal Biol. 122:1125-1133(2018).
CC   -!- FUNCTION: Effector that may act as a suppressor of cell death to
CC       interrupt plant immunity. I. {ECO:0000305|Ref.3}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:22749169}. Host cell
CC       {ECO:0000269|PubMed:22749169}.
CC   -!- INDUCTION: Expression is up-regulated at the earlier infection stages.
CC       {ECO:0000269|PubMed:22749169, ECO:0000269|PubMed:30449350,
CC       ECO:0000269|Ref.3}.
CC   -!- DOMAIN: The RxLR-dEER motif acts to carry the protein into the host
CC       cell cytoplasm through binding to cell surface phosphatidylinositol-3-
CC       phosphate. {ECO:0000305|Ref.3}.
CC   -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR   EMBL; HE582030; CCD28104.1; -; mRNA.
DR   AlphaFoldDB; H6S3X4; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0043657; C:host cell; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Secreted; Signal; Virulence.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..106
FT                   /note="Secreted RxLR effector protein 18"
FT                   /id="PRO_5003607112"
FT   MOTIF           28..39
FT                   /note="RxLR-dEER"
FT                   /evidence="ECO:0000305|Ref.3"
SQ   SEQUENCE   106 AA;  11097 MW;  3EA044A791C67DB3 CRC64;
     MRGSTAMLLA AIALFSSQSF ATAIGKSRTL RSFEELEERQ LASGSGSNNG LDDVKRSALV
     ELLGEKVVAG GPTSILKAMM KLSDEELQNF IDKNIGSDSD SASGGN