ID   RLR22_PLAVT             Reviewed;         125 AA.
AC   A0A182BSS1;
DT   08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT   07-SEP-2016, sequence version 1.
DT   25-MAY-2022, entry version 11.
DE   RecName: Full=Secreted RxLR effector protein 22 {ECO:0000303|Ref.2};
DE   Flags: Precursor;
GN   Name=RxLR22 {ECO:0000303|Ref.2};
OS   Plasmopara viticola (Downy mildew of grapevine) (Botrytis viticola).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Plasmopara.
OX   NCBI_TaxID=143451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, FUNCTION, AND SUBCELLULAR LOCATION.
RC   STRAIN=ZJ-1-1;
RX   PubMed=27242731; DOI=10.3389/fmicb.2016.00709;
RA   Xiang J., Li X., Wu J., Yin L., Zhang Y., Lu J.;
RT   "Studying the mechanism of Plasmopara viticola RxLR effectors on
RT   suppressing plant immunity.";
RL   Front. Microbiol. 7:709-709(2016).
RN   [2]
RP   IDENTIFICATION, INDUCTION, AND DOMAIN.
RX   DOI=10.1016/j.pmpp.2015.05.002;
RA   Yin L., Li X., Xiang J., Qu J., Zhang Y., Dry I.B., Lu J.;
RT   "Characterization of the secretome of Plasmopara viticola by de novo
RT   transcriptome analysis.";
RL   Physiol. Mol. Plant Pathol. 91:1-10(2015).
CC   -!- FUNCTION: Effector that acts as a broad suppressor of cell death to
CC       interrupt plant immunity. Inhibits cell death induced by cell death-
CC       inducing proteins, including the PAMP elicitor INF1 from P.infestans.
CC       {ECO:0000269|PubMed:27242731}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:27242731}. Host
CC       nucleus {ECO:0000269|PubMed:27242731}.
CC   -!- INDUCTION: Expression is up-regulated at the earlier infection stages.
CC       {ECO:0000269|PubMed:27242731, ECO:0000269|Ref.2}.
CC   -!- DOMAIN: The RxLR-dEER motif acts to carry the protein into the host
CC       cell cytoplasm through binding to cell surface phosphatidylinositol-3-
CC       phosphate. {ECO:0000305|Ref.2}.
CC   -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR   EMBL; KX010955; ANC73375.1; -; mRNA.
DR   AlphaFoldDB; A0A182BSS1; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Host nucleus; Secreted; Signal; Virulence.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..125
FT                   /note="Secreted RxLR effector protein 22"
FT                   /id="PRO_5008116093"
FT   REGION          20..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           32..50
FT                   /note="RxLR-dEER"
FT                   /evidence="ECO:0000305|Ref.2"
SQ   SEQUENCE   125 AA;  14038 MW;  233533777011B3FB CRC64;
     MRLIYSALVT AAAMVAISNG STPARGNEVE TRSLRGGNEV DSSMSDDGER AARGGGRVRS
     QASGVTRHVG GGGPFIGFWY PYYNFEEKKE KKEKHHLSDE YEEYRRIAAE VKRKRQDKRL
     AERQD