ID   RLR24_PLAVT             Reviewed;         510 AA.
AC   P0CV01;
DT   18-SEP-2019, integrated into UniProtKB/Swiss-Prot.
DT   18-SEP-2019, sequence version 1.
DT   25-MAY-2022, entry version 8.
DE   RecName: Full=Secreted RxLR effector protein 24 {ECO:0000303|PubMed:29706971};
DE   Flags: Precursor;
GN   Name=RXLR24 {ECO:0000303|PubMed:29706971};
OS   Plasmopara viticola (Downy mildew of grapevine) (Botrytis viticola).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Plasmopara.
OX   NCBI_TaxID=143451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], DOMAIN, FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=29706971; DOI=10.3389/fpls.2018.00286;
RA   Liu Y., Lan X., Song S., Yin L., Dry I.B., Qu J., Xiang J., Lu J.;
RT   "In planta functional analysis and subcellular localization of the oomycete
RT   pathogen Plasmopara viticola candidate RXLR effector repertoire.";
RL   Front. Plant Sci. 9:286-286(2018).
CC   -!- FUNCTION: Secreted effector that acts as an elicitor that induces cell
CC       death in host plant cells. {ECO:0000269|PubMed:29706971}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:29706971}. Host
CC       nucleus {ECO:0000269|PubMed:29706971}. Note=Localizes to speckle-like
CC       structures within the nucleus. {ECO:0000269|PubMed:29706971}.
CC   -!- DOMAIN: The RxLR-dEER motif acts to carry the protein into the host
CC       cell cytoplasm through binding to cell surface phosphatidylinositol-3-
CC       phosphate. {ECO:0000305|PubMed:29706971}.
CC   -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR   AlphaFoldDB; P0CV01; -.
DR   SMR; P0CV01; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Host nucleus; Secreted; Signal; Virulence.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..510
FT                   /note="Secreted RxLR effector protein 24"
FT                   /id="PRO_0000447910"
FT   MOTIF           47..68
FT                   /note="RxLR-dEER"
FT                   /evidence="ECO:0000305|PubMed:29706971"
SQ   SEQUENCE   510 AA;  56723 MW;  6594F1D8E60DAFEB CRC64;
     MRGAFYVAIA LLGSHTAAEC NQDEPQGAPN NDFLTFGGTI EKMLPRRVLR ERRDSKDKLT
     VHAGAEERVM DPPPEAVEQA IMKTAGVMRT DSDDVIARAA GAIRAHEEIE ALFRRIDPTL
     YNVNGQALHA LPKPTNYMVS VASDIPTVPA KRAKVKASAD VINNAAWRVS KHDLRLAPPE
     PSPSSIASSG IRFDNQPIAE KAFKLDLNKH SDEVEIINSN SKRKRIDLTP SHVGEQAPHP
     LPELQKYKVS VAVSIPMVLA TKLEGDGPTL IMRNAANIIT THDFRPAPFG SSTRTVASSN
     SQIHSQPIAQ EASKFALNVD PNEVKSLFHE NLPLVGHALH TRVGNDELVP LATVNSIKAG
     NTQGPYVHKP RMATDEEIHA AFLEAFNLPF HQYLYETSIM IKIVKRQYKT SPGNHRIVES
     FSSLVNNQEL SKLKESLGPD LQNLLAGMLE LQDDLKSLRE AYYVKLLIMY ELFYDFCYVR
     LDLFDALVPK VDRTVWILKL KNYETLPSHD