ID   RLR25_PLAHL             Reviewed;         122 AA.
AC   A0A0P1B8W9;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   20-JAN-2016, sequence version 1.
DT   25-MAY-2022, entry version 17.
DE   RecName: Full=Secreted RxLR effector protein RXLR-C251 {ECO:0000303|PubMed:30422341};
DE   Flags: Precursor;
GN   Name=RXLR-C25 {ECO:0000303|PubMed:30422341};
OS   Plasmopara halstedii (Downy mildew of sunflower).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Plasmopara.
OX   NCBI_TaxID=4781;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=26438312; DOI=10.1186/s12864-015-1904-7;
RA   Sharma R., Xia X., Cano L.M., Evangelisti E., Kemen E., Judelson H.,
RA   Oome S., Sambles C., van den Hoogen D.J., Kitner M., Klein J., Meijer H.J.,
RA   Spring O., Win J., Zipper R., Bode H.B., Govers F., Kamoun S.,
RA   Schornack S., Studholme D.J., Van den Ackerveken G., Thines M.;
RT   "Genome analyses of the sunflower pathogen Plasmopara halstedii provide
RT   insights into effector evolution in downy mildews and Phytophthora.";
RL   BMC Genomics 16:741-741(2015).
RN   [2]
RP   DOMAIN, INDUCTION, FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=30422341; DOI=10.1111/tpj.14157;
RA   Pecrix Y., Buendia L., Penouilh-Suzette C., Marechaux M., Legrand L.,
RA   Bouchez O., Rengel D., Gouzy J., Cottret L., Vear F., Godiard L.;
RT   "Sunflower resistance to multiple downy mildew pathotypes revealed by
RT   recognition of conserved effectors of the oomycete Plasmopara halstedii.";
RL   Plant J. 97:730-748(2019).
CC   -!- FUNCTION: Secreted effector that does not suppress pattern-triggered
CC       immunity (PTI) in plant host. {ECO:0000269|PubMed:30422341}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:30422341}. Host
CC       cytoplasm {ECO:0000269|PubMed:30422341}. Host nucleus
CC       {ECO:0000269|PubMed:30422341}.
CC   -!- INDUCTION: Expression is up-regulated in spores.
CC       {ECO:0000269|PubMed:30422341}.
CC   -!- DOMAIN: Has the canonical translocation RxLR motif, but lacks the
CC       canonical EER motif, which characterizes most oomycete effectors
CC       identified so far. {ECO:0000305|PubMed:30422341}.
CC   -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR   EMBL; CCYD01000116; CEG50476.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0P1B8W9; -.
DR   EnsemblProtists; CEG50476; CEG50476; CEG50476.
DR   OMA; AGCDSAF; -.
DR   OrthoDB; 1626411at2759; -.
DR   Proteomes; UP000054928; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Host cytoplasm; Host nucleus; Reference proteome; Secreted; Signal;
KW   Virulence.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..122
FT                   /note="Secreted RxLR effector protein RXLR-C251"
FT                   /id="PRO_5006059287"
FT   MOTIF           48..51
FT                   /note="RxLR"
FT                   /evidence="ECO:0000305|PubMed:30422341"
SQ   SEQUENCE   122 AA;  13973 MW;  B79E8E00AEBA6D12 CRC64;
     MRFFYKLALM TTVASLACSD TALASTDLMP FNVAETQVST HDIVSAGRSL RAEDTSTSID
     NLRDPTMKEK IQFKLWYTRG KTPGQVHRDF FEGLDESIIV NNPNYEVWKM YEAYYNNKKG
     ND