ID   RLR25_PLAVT             Reviewed;         416 AA.
AC   A0A172M470;
DT   08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT   07-SEP-2016, sequence version 1.
DT   25-MAY-2022, entry version 11.
DE   RecName: Full=Secreted RxLR effector protein 25 {ECO:0000303|Ref.2};
DE   Flags: Precursor;
GN   Name=RxLR25 {ECO:0000303|Ref.2};
OS   Plasmopara viticola (Downy mildew of grapevine) (Botrytis viticola).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Plasmopara.
OX   NCBI_TaxID=143451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, FUNCTION, AND SUBCELLULAR LOCATION.
RC   STRAIN=ZJ-1-1;
RX   PubMed=27242731; DOI=10.3389/fmicb.2016.00709;
RA   Xiang J., Li X., Wu J., Yin L., Zhang Y., Lu J.;
RT   "Studying the mechanism of Plasmopara viticola RxLR effectors on
RT   suppressing plant immunity.";
RL   Front. Microbiol. 7:709-709(2016).
RN   [2]
RP   IDENTIFICATION, INDUCTION, AND DOMAIN.
RX   DOI=10.1016/j.pmpp.2015.05.002;
RA   Yin L., Li X., Xiang J., Qu J., Zhang Y., Dry I.B., Lu J.;
RT   "Characterization of the secretome of Plasmopara viticola by de novo
RT   transcriptome analysis.";
RL   Physiol. Mol. Plant Pathol. 91:1-10(2015).
CC   -!- FUNCTION: Effector that partially suppresses the tobacco programmed
CC       cell death induced by cell death-inducing proteins.
CC       {ECO:0000269|PubMed:27242731}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:27242731}. Host
CC       cytoplasm {ECO:0000269|PubMed:27242731}. Host nucleus
CC       {ECO:0000269|PubMed:27242731}.
CC   -!- INDUCTION: Expression is up-regulated at the earlier infection stages.
CC       {ECO:0000269|PubMed:27242731, ECO:0000269|Ref.2}.
CC   -!- DOMAIN: The RxLR-dEER motif acts to carry the protein into the host
CC       cell cytoplasm through binding to cell surface phosphatidylinositol-3-
CC       phosphate. {ECO:0000305|Ref.2}.
CC   -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR   EMBL; KX010956; ANC73376.1; -; mRNA.
DR   AlphaFoldDB; A0A172M470; -.
DR   SMR; A0A172M470; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Host cytoplasm; Host nucleus; Secreted; Signal; Virulence.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..416
FT                   /note="Secreted RxLR effector protein 25"
FT                   /id="PRO_5007999408"
FT   MOTIF           49..88
FT                   /note="RxLR-dEER"
FT                   /evidence="ECO:0000305|Ref.2"
SQ   SEQUENCE   416 AA;  48494 MW;  AAFB746F0438064B CRC64;
     MRSWLLLLVG LSSYFALSTS VNRAKNSGSD FDLESRASTT NVNSILSKRK LRAPGGDTNT
     LKDSGKARRE KKVWKLFCRV FLQLDDEKKC MFETNQVSSH QPEPRPALSF MPGPKPAHSL
     VPESKPVRSL MTGNAPVRSI ATKLKLVLPR ITETVKNPSK SQVVMLWLHK VAEFSRSEHG
     VNTMSYRTLY EWLSPSFSDA KLAKFFVGLR EDEALRETAE KMLAYMLIKS TSTEAVGRAW
     LKSGEHPSRL FESMNFKEAD FKDTVFLGWL KYASLYEKHY FSQSELTDYR RQLFFYRMYD
     YIKPMYSYEK TQGFLEYKFE GLTSIPGMQD FGQNLADIAR RERKISFYLD SEFTPEALFN
     YLKVSDENLL TNVFQWLRYC RRYTMAYKYV PFDELEFLEE KLGEISLWIY QVYGKL