ID   RLR35_PLAVT             Reviewed;         435 AA.
AC   P0CV04;
DT   18-SEP-2019, integrated into UniProtKB/Swiss-Prot.
DT   18-SEP-2019, sequence version 1.
DT   25-MAY-2022, entry version 9.
DE   RecName: Full=Secreted RxLR effector protein 35 {ECO:0000303|PubMed:29706971};
DE   Flags: Precursor;
GN   Name=RXLR35 {ECO:0000303|PubMed:29706971};
OS   Plasmopara viticola (Downy mildew of grapevine) (Botrytis viticola).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Plasmopara.
OX   NCBI_TaxID=143451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], DOMAIN, FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=29706971; DOI=10.3389/fpls.2018.00286;
RA   Liu Y., Lan X., Song S., Yin L., Dry I.B., Qu J., Xiang J., Lu J.;
RT   "In planta functional analysis and subcellular localization of the oomycete
RT   pathogen Plasmopara viticola candidate RXLR effector repertoire.";
RL   Front. Plant Sci. 9:286-286(2018).
CC   -!- FUNCTION: Secreted effector that acts as an elicitor that induces cell
CC       death in host plant cells. {ECO:0000269|PubMed:29706971}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:29706971}. Host
CC       nucleus {ECO:0000269|PubMed:29706971}.
CC   -!- DOMAIN: The RxLR-dEER motif acts to carry the protein into the host
CC       cell cytoplasm through binding to cell surface phosphatidylinositol-3-
CC       phosphate. {ECO:0000305|PubMed:29706971}.
CC   -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR   AlphaFoldDB; P0CV04; -.
DR   SMR; P0CV04; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Host nucleus; Secreted; Signal; Virulence.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..435
FT                   /note="Secreted RxLR effector protein 35"
FT                   /id="PRO_0000447913"
FT   REGION          336..357
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           48..65
FT                   /note="RxLR-dEER"
FT                   /evidence="ECO:0000305|PubMed:29706971"
FT   COMPBIAS        338..354
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   435 AA;  48858 MW;  BA02064F9F804900 CRC64;
     MRGAYYIIIA LCVVASSQVA AGSDRQLQIY EHGVMPADNA VVKTLAKRFL RGSRVVHDDL
     ANEERSFHPF LVDMIEEGIK EMSHAAEIVE EMPLAGKVVE EVPHATEGGQ QKMDKGAEEA
     FEKHVEPSGH TATIQDTSRD ISTQEVIQLS PHEWESDLSK LKPFVVLNKH RGRIEPVKDA
     FAAFCDEGLK PTTEETSIIW SMLGWNLARK PKGKHRQHLI AQARRGVLLD LRIVRMDESL
     WNKWMQLPKP LRMLKLNNLL NMHYQRWVHL FNIFQRRLSE IIGPPPKLKV AHGDTTDTSK
     ALALHTHSNM QSSTPSEPLN AASTFKVERF VWGANRPKRT TDGNTGTISL PTKPTKTHRL
     KPLMPRLTES TTSSDLLVPT KRMRLSFGGT RSAFAPYKDP KEKLLAPSST ALTHKDIDLD
     LSLGGIYGKR TDKAL