ID   RLR49_PLAVT             Reviewed;         124 AA.
AC   A0A182BSS2;
DT   08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT   07-SEP-2016, sequence version 1.
DT   25-MAY-2022, entry version 12.
DE   RecName: Full=Secreted RxLR effector protein 49 {ECO:0000303|PubMed:27242731};
DE   Flags: Precursor;
GN   Name=RxLR49 {ECO:0000303|PubMed:27242731};
OS   Plasmopara viticola (Downy mildew of grapevine) (Botrytis viticola).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Plasmopara.
OX   NCBI_TaxID=143451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, FUNCTION, SUBCELLULAR LOCATION, AND
RP   DOMAIN.
RC   STRAIN=ZJ-1-1;
RX   PubMed=27242731; DOI=10.3389/fmicb.2016.00709;
RA   Xiang J., Li X., Wu J., Yin L., Zhang Y., Lu J.;
RT   "Studying the mechanism of Plasmopara viticola RxLR effectors on
RT   suppressing plant immunity.";
RL   Front. Microbiol. 7:709-709(2016).
CC   -!- FUNCTION: Effector that acts as a broad suppressor of cell death to
CC       interrupt plant immunity. Inhibits cell death induced by cell death-
CC       inducing proteins, including the PAMP elicitor INF1 from P.infestans.
CC       {ECO:0000269|PubMed:27242731}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:27242731}. Host
CC       cytoplasm {ECO:0000269|PubMed:27242731}. Host nucleus
CC       {ECO:0000269|PubMed:27242731}.
CC   -!- INDUCTION: Expression is up-regulated at later stages of infection.
CC       {ECO:0000269|PubMed:27242731}.
CC   -!- DOMAIN: Has a conserved RxLR motif that acts to carry the protein into
CC       the host cell cytoplasm. Lacks the 'so-called' EER motif, which is
CC       found closely behind the RxLR motif in most of RxLR effector family
CC       members, but the presence of an EER motif is not always essential for
CC       the translocation of every RxLR effector into host cells, or for
CC       inducing a hypersensitive response. {ECO:0000305|PubMed:27242731}.
CC   -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR   EMBL; KX010961; ANC73381.1; -; mRNA.
DR   AlphaFoldDB; A0A182BSS2; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Host cytoplasm; Host nucleus; Secreted; Signal; Virulence.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..124
FT                   /note="Secreted RxLR effector protein 49"
FT                   /id="PRO_5008116090"
FT   MOTIF           57..60
FT                   /note="RxLR"
FT                   /evidence="ECO:0000305|PubMed:27242731"
SQ   SEQUENCE   124 AA;  14276 MW;  CBF62572DB2D7CBD CRC64;
     MIRRSPLVAV ILFVAITHVV LALDDATRID SSEIVPSEPT RRTRVSPHYI SSGGSKRSLR
     QQAFRPVAYL KNKLNWFLSR FFGTPTDAFT QMNSPRSSRI ANIFRKIYMH TAKDDEYFSR
     LRSV