ID   RLR61_PLAVT             Reviewed;         102 AA.
AC   A0A182BSS4;
DT   08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT   07-SEP-2016, sequence version 1.
DT   25-MAY-2022, entry version 12.
DE   RecName: Full=Secreted RxLR effector protein 61 {ECO:0000303|PubMed:27242731};
DE   Flags: Precursor;
GN   Name=RxLR61 {ECO:0000303|PubMed:27242731, ECO:0000303|PubMed:29706971};
OS   Plasmopara viticola (Downy mildew of grapevine) (Botrytis viticola).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Plasmopara.
OX   NCBI_TaxID=143451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, FUNCTION, SUBCELLULAR LOCATION, AND
RP   DOMAIN.
RC   STRAIN=ZJ-1-1;
RX   PubMed=27242731; DOI=10.3389/fmicb.2016.00709;
RA   Xiang J., Li X., Wu J., Yin L., Zhang Y., Lu J.;
RT   "Studying the mechanism of Plasmopara viticola RxLR effectors on
RT   suppressing plant immunity.";
RL   Front. Microbiol. 7:709-709(2016).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], DOMAIN, FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=29706971; DOI=10.3389/fpls.2018.00286;
RA   Liu Y., Lan X., Song S., Yin L., Dry I.B., Qu J., Xiang J., Lu J.;
RT   "In planta functional analysis and subcellular localization of the oomycete
RT   pathogen Plasmopara viticola candidate RXLR effector repertoire.";
RL   Front. Plant Sci. 9:286-286(2018).
CC   -!- FUNCTION: Effector that partially suppresses the tobacco programmed
CC       cell death induced by cell death-inducing proteins.
CC       {ECO:0000269|PubMed:27242731, ECO:0000269|PubMed:29706971}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:27242731,
CC       ECO:0000269|PubMed:29706971}. Host chloroplast envelope
CC       {ECO:0000269|PubMed:29706971}. Host cytoplasm
CC       {ECO:0000269|PubMed:27242731}. Host nucleus
CC       {ECO:0000269|PubMed:27242731, ECO:0000269|PubMed:29706971}.
CC   -!- INDUCTION: Expression is up-regulated at the earlier infection stages.
CC       {ECO:0000269|PubMed:27242731}.
CC   -!- DOMAIN: The RxLR-dEER motif acts to carry the protein into the host
CC       cell cytoplasm through binding to cell surface phosphatidylinositol-3-
CC       phosphate. {ECO:0000305|PubMed:27242731}.
CC   -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR   EMBL; KX010963; ANC73383.1; -; mRNA.
DR   AlphaFoldDB; A0A182BSS4; -.
DR   SMR; A0A182BSS4; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Host cytoplasm; Host nucleus; Secreted; Signal; Virulence.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..102
FT                   /note="Secreted RxLR effector protein 61"
FT                   /id="PRO_5008116101"
FT   MOTIF           51..60
FT                   /note="RxLR-dEER"
FT                   /evidence="ECO:0000305|PubMed:27242731"
SQ   SEQUENCE   102 AA;  12219 MW;  73154FEBF8CD2E28 CRC64;
     MAFQLRIVQH LLHITFLRLP LAYPSQIHQR ENERMFLLRI HRQDVQHLSH RRLRQLNEHR
     SLLPKGFPFK LLRPLPQLQR LLSQVCRGSV RIDACCCIPS CH