ID   RLR63_PLAVT             Reviewed;         136 AA.
AC   A0A172M490;
DT   08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT   07-SEP-2016, sequence version 1.
DT   25-MAY-2022, entry version 10.
DE   RecName: Full=Secreted RxLR effector protein 63 {ECO:0000303|PubMed:27242731};
DE   Flags: Precursor;
GN   Name=RxLR63 {ECO:0000303|PubMed:27242731};
OS   Plasmopara viticola (Downy mildew of grapevine) (Botrytis viticola).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Plasmopara.
OX   NCBI_TaxID=143451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, FUNCTION, SUBCELLULAR LOCATION, AND
RP   DOMAIN.
RC   STRAIN=ZJ-1-1;
RX   PubMed=27242731; DOI=10.3389/fmicb.2016.00709;
RA   Xiang J., Li X., Wu J., Yin L., Zhang Y., Lu J.;
RT   "Studying the mechanism of Plasmopara viticola RxLR effectors on
RT   suppressing plant immunity.";
RL   Front. Microbiol. 7:709-709(2016).
CC   -!- FUNCTION: Effector that partially suppresses the tobacco programmed
CC       cell death induced by cell death-inducing proteins.
CC       {ECO:0000269|PubMed:27242731}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:27242731}. Host
CC       nucleus {ECO:0000269|PubMed:27242731}.
CC   -!- INDUCTION: Expression is up-regulated at later stages of infection.
CC       {ECO:0000269|PubMed:27242731}.
CC   -!- DOMAIN: Has a conserved RxLR motif that acts to carry the protein into
CC       the host cell cytoplasm. Lacks the 'so-called' EER motif, which is
CC       found closely behind the RxLR motif in most of RxLR effector family
CC       members, but the presence of an EER motif is not always essential for
CC       the translocation of every RxLR effector into host cells, or for
CC       inducing a hypersensitive response. {ECO:0000305|PubMed:27242731}.
CC   -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR   EMBL; KX010964; ANC73384.1; -; mRNA.
DR   AlphaFoldDB; A0A172M490; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Host nucleus; Secreted; Signal; Virulence.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..136
FT                   /note="Secreted RxLR effector protein 63"
FT                   /id="PRO_5007999409"
FT   MOTIF           43..46
FT                   /note="RxLR"
FT                   /evidence="ECO:0000305|PubMed:27242731"
SQ   SEQUENCE   136 AA;  16589 MW;  06C26C3EAB748E67 CRC64;
     MQRFPYSLLL LLLSATNRSR RHHITRPGRS IHWCLVRPTR PNRMLRAIRT CGARYWRNWP
     LNWPRKAGLT RRSSARIGLS DALRPCPTLF GCFKRRYARQ AMSCYCRTEW RVNWLKKKRR
     GSSRWRRESS VWRCWK