ID   RLR64_PLAVT             Reviewed;         101 AA.
AC   A0A182BSS5;
DT   08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT   07-SEP-2016, sequence version 1.
DT   25-MAY-2022, entry version 10.
DE   RecName: Full=Secreted RxLR effector protein 64 {ECO:0000303|PubMed:27242731};
DE   Flags: Precursor;
GN   Name=RxLR64 {ECO:0000303|PubMed:27242731};
OS   Plasmopara viticola (Downy mildew of grapevine) (Botrytis viticola).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Plasmopara.
OX   NCBI_TaxID=143451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, FUNCTION, SUBCELLULAR LOCATION, AND
RP   DOMAIN.
RC   STRAIN=ZJ-1-1;
RX   PubMed=27242731; DOI=10.3389/fmicb.2016.00709;
RA   Xiang J., Li X., Wu J., Yin L., Zhang Y., Lu J.;
RT   "Studying the mechanism of Plasmopara viticola RxLR effectors on
RT   suppressing plant immunity.";
RL   Front. Microbiol. 7:709-709(2016).
CC   -!- FUNCTION: Effector that acts as a broad suppressor of cell death to
CC       interrupt plant immunity. Inhibits cell death induced by cell death-
CC       inducing proteins, including the PAMP elicitor INF1 from P.infestans.
CC       {ECO:0000269|PubMed:27242731}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:27242731}. Host
CC       cytoplasm {ECO:0000269|PubMed:27242731}. Host nucleus
CC       {ECO:0000269|PubMed:27242731}. Membrane {ECO:0000255}; Single-pass
CC       membrane protein {ECO:0000255}.
CC   -!- INDUCTION: Expression is up-regulated at the earlier infection stages.
CC       {ECO:0000269|PubMed:27242731}.
CC   -!- DOMAIN: Has a conserved RxLR motif that acts to carry the protein into
CC       the host cell cytoplasm. Lacks the 'so-called' EER motif, which is
CC       found closely behind the RxLR motif in most of RxLR effector family
CC       members, but the presence of an EER motif is not always essential for
CC       the translocation of every RxLR effector into host cells, or for
CC       inducing a hypersensitive response. {ECO:0000305|PubMed:27242731}.
CC   -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR   EMBL; KX010965; ANC73385.1; -; mRNA.
DR   AlphaFoldDB; A0A182BSS5; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Host cytoplasm; Host nucleus; Membrane; Secreted; Signal; Transmembrane;
KW   Transmembrane helix; Virulence.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..101
FT                   /note="Secreted RxLR effector protein 64"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000446908"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOTIF           48..51
FT                   /note="RxLR"
FT                   /evidence="ECO:0000305|PubMed:27242731"
SQ   SEQUENCE   101 AA;  11272 MW;  1BFDA6B41368B307 CRC64;
     MMSPPMTTTL MFILNYAIIS FHGQPSGISW GNHIETAEAA AILAMANREL RSRELLLWTS
     GSTHLLLQPI LPLPLCLPFP LVPASIFKKM MLPLSAFSFW M