ID   RLR68_PLAVT             Reviewed;         130 AA.
AC   A0A172M4N1;
DT   08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT   07-SEP-2016, sequence version 1.
DT   25-MAY-2022, entry version 10.
DE   RecName: Full=Secreted RxLR effector protein 68 {ECO:0000303|PubMed:27242731};
DE   Flags: Precursor;
GN   Name=RxLR68 {ECO:0000303|PubMed:27242731};
OS   Plasmopara viticola (Downy mildew of grapevine) (Botrytis viticola).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Plasmopara.
OX   NCBI_TaxID=143451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, FUNCTION, SUBCELLULAR LOCATION, AND
RP   DOMAIN.
RC   STRAIN=ZJ-1-1;
RX   PubMed=27242731; DOI=10.3389/fmicb.2016.00709;
RA   Xiang J., Li X., Wu J., Yin L., Zhang Y., Lu J.;
RT   "Studying the mechanism of Plasmopara viticola RxLR effectors on
RT   suppressing plant immunity.";
RL   Front. Microbiol. 7:709-709(2016).
CC   -!- FUNCTION: Effector that acts as a broad suppressor of cell death to
CC       interrupt plant immunity. Inhibits cell death induced by cell death-
CC       inducing proteins, including the PAMP elicitor INF1 from P.infestans.
CC       {ECO:0000269|PubMed:27242731}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:27242731}. Host
CC       cytoplasm {ECO:0000269|PubMed:27242731}. Host nucleus
CC       {ECO:0000269|PubMed:27242731}.
CC   -!- INDUCTION: Expression is up-regulated at later stages of infection.
CC       {ECO:0000269|PubMed:27242731}.
CC   -!- DOMAIN: Has a conserved RxLR motif that acts to carry the protein into
CC       the host cell cytoplasm. Lacks the 'so-called' EER motif, which is
CC       found closely behind the RxLR motif in most of RxLR effector family
CC       members, but the presence of an EER motif is not always essential for
CC       the translocation of every RxLR effector into host cells, or for
CC       inducing a hypersensitive response. {ECO:0000305|PubMed:27242731}.
CC   -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR   EMBL; KX010968; ANC73388.1; -; mRNA.
DR   AlphaFoldDB; A0A172M4N1; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Host cytoplasm; Host nucleus; Secreted; Signal; Virulence.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..130
FT                   /note="Secreted RxLR effector protein 68"
FT                   /id="PRO_5007999415"
FT   MOTIF           45..48
FT                   /note="RxLR"
FT                   /evidence="ECO:0000305|PubMed:27242731"
FT   CARBOHYD        36
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   130 AA;  14013 MW;  D6E3B6F178624E84 CRC64;
     MRCVCASIRR TRIIEFLMFF ALSSSTASCA PFSVSNVTHA SPRPRWLRWH EKTSMAGNPV
     SLSIATPNGA KSSSICSANT VGFTPDTYTC PDIRDSSTDT LSRSKRISSL SLTKPISSSS
     ESETKVLSAS