ID   RLR70_PLAVT             Reviewed;         451 AA.
AC   P0CV21;
DT   18-SEP-2019, integrated into UniProtKB/Swiss-Prot.
DT   18-SEP-2019, sequence version 1.
DT   25-MAY-2022, entry version 10.
DE   RecName: Full=Secreted RxLR effector protein 70 {ECO:0000303|PubMed:29706971};
DE   Flags: Precursor;
GN   Name=RXLR70 {ECO:0000303|PubMed:29706971};
OS   Plasmopara viticola (Downy mildew of grapevine) (Botrytis viticola).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Plasmopara.
OX   NCBI_TaxID=143451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], DOMAIN, FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=29706971; DOI=10.3389/fpls.2018.00286;
RA   Liu Y., Lan X., Song S., Yin L., Dry I.B., Qu J., Xiang J., Lu J.;
RT   "In planta functional analysis and subcellular localization of the oomycete
RT   pathogen Plasmopara viticola candidate RXLR effector repertoire.";
RL   Front. Plant Sci. 9:286-286(2018).
CC   -!- FUNCTION: Secreted effector that completely suppresses the host cell
CC       death induced by cell death-inducing proteins.
CC       {ECO:0000269|PubMed:29706971}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:29706971}. Host
CC       nucleus {ECO:0000269|PubMed:29706971}.
CC   -!- DOMAIN: The RxLR-dEER motif acts to carry the protein into the host
CC       cell cytoplasm through binding to cell surface phosphatidylinositol-3-
CC       phosphate. {ECO:0000305|PubMed:29706971}.
CC   -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR   AlphaFoldDB; P0CV21; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Host nucleus; Secreted; Signal; Virulence.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..451
FT                   /note="Secreted RxLR effector protein 70"
FT                   /id="PRO_0000447930"
FT   REGION          303..336
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           48..65
FT                   /note="RxLR-dEER"
FT                   /evidence="ECO:0000305|PubMed:29706971"
FT   COMPBIAS        308..329
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   451 AA;  50027 MW;  429704BDAA6AA36C CRC64;
     MRGAYYIITA LLVVASSQEL RGSGHQLQIY DHDVVKAVKA VMKTLPNRFL RESRDVHDDL
     ANEERSFYSI LADIINKGMD TMPRAAEGVE LMPNAAEGVE KMPRAAEGVE TIPHAAEGVE
     NMPHVPDEGL SKALTGAKTA LNKLWGPFSA TTPIGDASHD VSSREQIDFE IGSWSIDLRG
     FKPIAVHDQH KDMIQRVYTK FGQLCGNNLN PTAEETSLIW TMFDSRIVPS SSKDDRLKLI
     WQARQNVRSD MRSISSSKKW RYRWQGSPDS LTLDVLNSLL NMHYQRWVRM YDIFKQERPD
     LIDAPSNSKH TLGGNKDSSS ATTLHKHSKG LSSRPFEPLN AVMMSHGDRF VSTQRSKRTF
     GSNADTVSLP LKQPKMRSSK ALMPLSATLG DYSVPPLKSR LNFGGASSAF VPYTHPKAHT
     SKSLAPASTT LTLKDSELEL SLGGIYDKNT G