ID   RLR76_PLAVT             Reviewed;         306 AA.
AC   P0CV24;
DT   18-SEP-2019, integrated into UniProtKB/Swiss-Prot.
DT   18-SEP-2019, sequence version 1.
DT   25-MAY-2022, entry version 9.
DE   RecName: Full=Secreted RxLR effector protein 76 {ECO:0000303|PubMed:29706971};
DE   Flags: Precursor;
GN   Name=RXLR76 {ECO:0000303|PubMed:29706971};
OS   Plasmopara viticola (Downy mildew of grapevine) (Botrytis viticola).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Plasmopara.
OX   NCBI_TaxID=143451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], DOMAIN, FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=29706971; DOI=10.3389/fpls.2018.00286;
RA   Liu Y., Lan X., Song S., Yin L., Dry I.B., Qu J., Xiang J., Lu J.;
RT   "In planta functional analysis and subcellular localization of the oomycete
RT   pathogen Plasmopara viticola candidate RXLR effector repertoire.";
RL   Front. Plant Sci. 9:286-286(2018).
CC   -!- FUNCTION: Secreted effector that partially suppresses the host cell
CC       death induced by cell death-inducing proteins.
CC       {ECO:0000269|PubMed:29706971}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:29706971}. Host
CC       nucleus {ECO:0000269|PubMed:29706971}. Note=Localizes to bulk/chunk-
CC       like structures within the nucleus. {ECO:0000269|PubMed:29706971}.
CC   -!- DOMAIN: The RxLR-dEER motif acts to carry the protein into the host
CC       cell cytoplasm through binding to cell surface phosphatidylinositol-3-
CC       phosphate. {ECO:0000305|PubMed:29706971}.
CC   -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR   AlphaFoldDB; P0CV24; -.
DR   SMR; P0CV24; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Host nucleus; Secreted; Signal; Virulence.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..306
FT                   /note="Secreted RxLR effector protein 76"
FT                   /id="PRO_0000447933"
FT   REGION          105..142
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           48..65
FT                   /note="RxLR-dEER"
FT                   /evidence="ECO:0000305|PubMed:29706971"
SQ   SEQUENCE   306 AA;  34261 MW;  72A16C89B23853B0 CRC64;
     MSGAFYVFTA LLLVASDQIA AESGKRLEMY KHDVMAASNA VVKSLPNRFL RGSRDEPDNL
     ANEERTVYSV LASMINEGVS KMPCAAEVVE KISHTTEAVE NMPRAAKAVK KRPRGAKAGR
     KMPRAAEAEA VKKVPRAGTA VKKAPPLAED VKEMPRAKEA MEELRRAADA TEDMQRAKAN
     DLLKALIGAD EALKKHWTPS GNTAAIGDTS YDVFNKVILS LPEWKINFRG MKSMAVLDQH
     RENIDLVHKT FEILCDKNVK PTAAEVSFIW SMMEWKGPNP EKYHRRNLVR QAQRYVFLDL
     RNVKKR