ID   RLR95_PLAVT             Reviewed;         517 AA.
AC   P0CV36;
DT   18-SEP-2019, integrated into UniProtKB/Swiss-Prot.
DT   18-SEP-2019, sequence version 1.
DT   25-MAY-2022, entry version 8.
DE   RecName: Full=Secreted RxLR effector protein 95 {ECO:0000303|PubMed:29706971};
DE   Flags: Precursor;
GN   Name=RXLR95 {ECO:0000303|PubMed:29706971};
OS   Plasmopara viticola (Downy mildew of grapevine) (Botrytis viticola).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Plasmopara.
OX   NCBI_TaxID=143451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], DOMAIN, FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=29706971; DOI=10.3389/fpls.2018.00286;
RA   Liu Y., Lan X., Song S., Yin L., Dry I.B., Qu J., Xiang J., Lu J.;
RT   "In planta functional analysis and subcellular localization of the oomycete
RT   pathogen Plasmopara viticola candidate RXLR effector repertoire.";
RL   Front. Plant Sci. 9:286-286(2018).
CC   -!- FUNCTION: Secreted effector that acts as an elicitor that induces cell
CC       death in host plant cells. {ECO:0000269|PubMed:29706971}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:29706971}. Host
CC       nucleus {ECO:0000269|PubMed:29706971}. Host cytoplasm
CC       {ECO:0000269|PubMed:29706971}.
CC   -!- DOMAIN: The RxLR-dEER motif acts to carry the protein into the host
CC       cell cytoplasm through binding to cell surface phosphatidylinositol-3-
CC       phosphate. {ECO:0000305|PubMed:29706971}.
CC   -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR   AlphaFoldDB; P0CV36; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Host cytoplasm; Host nucleus; Secreted; Signal; Virulence.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..517
FT                   /note="Secreted RxLR effector protein 95"
FT                   /id="PRO_0000447946"
FT   REGION          50..73
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          351..376
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           50..71
FT                   /note="RxLR-dEER"
FT                   /evidence="ECO:0000305|PubMed:29706971"
SQ   SEQUENCE   517 AA;  57224 MW;  D9F7108BEB3D5258 CRC64;
     MRGASYVAIA LFVTVSSQTA AECNQDKPQE GLNNGYVTFS GTIGKMLPRR VLQESRDSKD
     KSTVHAGAEE RMMDPPSEAF KSAIIKTAGV IMTGGEDAIA SAAMKTQEKS EALSLGRTSK
     RRGIDPPTYN VGGQALYALP KPNNNIVSMA SDVPIVLANR ARVKAPADLI NNAARSVSKH
     DLRLAPPGPS TSSTASFDTE KAFQFDLNKL PDEVEISNSK RQRIDLTPSH VVEQASHALP
     EPQKYIVTVA DSAPNVLARK LGKRDPTLIM QNAASVITKH DFRPAPYGPS SSTVASSVSQ
     IHSQPINQKA SKFALNVYPY EVKRLSQETL HPVGHVLHMR EENDMFVPSA TVNGESVPKD
     SKTKNTQGPR VHKTDKATGK VEHIHAAFLK AFNLPFHQYP QETAIMIHIV ERQVNSPGNR
     QFVEAFKSLV ERLQLPELKI ILGTDLEKLL GKESLKELLK KGSLEYQNAL KSLREAYYVK
     LAIMYELFYE FCYVRSDFFD RLVPKVDRTF WILKLSN