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RLUA_VIBVU
ID   RLUA_VIBVU              Reviewed;         250 AA.
AC   Q8DCG0;
DT   29-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Dual-specificity RNA pseudouridine synthase RluA {ECO:0000250|UniProtKB:P0AA37};
DE            EC=5.4.99.28 {ECO:0000250|UniProtKB:P0AA37};
DE            EC=5.4.99.29 {ECO:0000250|UniProtKB:P0AA37};
DE   AltName: Full=23S rRNA pseudouridine(746) synthase {ECO:0000250|UniProtKB:P0AA37};
DE   AltName: Full=Ribosomal large subunit pseudouridine synthase A {ECO:0000250|UniProtKB:P0AA37};
DE   AltName: Full=rRNA pseudouridylate synthase A {ECO:0000250|UniProtKB:P0AA37};
DE   AltName: Full=rRNA-uridine isomerase A {ECO:0000250|UniProtKB:P0AA37};
DE   AltName: Full=tRNA pseudouridine(32) synthase {ECO:0000250|UniProtKB:P0AA37};
GN   Name=rluA; OrderedLocusNames=VV1_1461;
OS   Vibrio vulnificus (strain CMCP6).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=216895;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CMCP6;
RA   Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.;
RT   "Complete genome sequence of Vibrio vulnificus CMCP6.";
RL   Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Dual specificity enzyme that catalyzes the synthesis of
CC       pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32
CC       in the anticodon stem and loop of transfer RNAs.
CC       {ECO:0000250|UniProtKB:P0AA37}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=uridine(32) in tRNA = pseudouridine(32) in tRNA;
CC         Xref=Rhea:RHEA:42544, Rhea:RHEA-COMP:10107, Rhea:RHEA-COMP:10108,
CC         ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; EC=5.4.99.28;
CC         Evidence={ECO:0000250|UniProtKB:P0AA37};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=uridine(746) in 23S rRNA = pseudouridine(746) in 23S rRNA;
CC         Xref=Rhea:RHEA:42548, Rhea:RHEA-COMP:10109, Rhea:RHEA-COMP:10110,
CC         ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; EC=5.4.99.29;
CC         Evidence={ECO:0000250|UniProtKB:P0AA37};
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC       {ECO:0000305}.
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DR   EMBL; AE016795; AAO09900.1; -; Genomic_DNA.
DR   RefSeq; WP_011079418.1; NC_004459.3.
DR   AlphaFoldDB; Q8DCG0; -.
DR   SMR; Q8DCG0; -.
DR   EnsemblBacteria; AAO09900; AAO09900; VV1_1461.
DR   KEGG; vvu:VV1_1461; -.
DR   HOGENOM; CLU_016902_11_1_6; -.
DR   OMA; HVSQSRM; -.
DR   Proteomes; UP000002275; Chromosome 1.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0120159; F:rRNA pseudouridine synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0106029; F:tRNA pseudouridine synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd02869; PseudoU_synth_RluA_like; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR   InterPro; IPR006224; PsdUridine_synth_RluC/D_CS.
DR   InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR   Pfam; PF00849; PseudoU_synth_2; 1.
DR   SUPFAM; SSF55120; SSF55120; 1.
DR   PROSITE; PS01129; PSI_RLU; 1.
PE   3: Inferred from homology;
KW   Isomerase; rRNA processing; tRNA processing.
FT   CHAIN           1..250
FT                   /note="Dual-specificity RNA pseudouridine synthase RluA"
FT                   /id="PRO_0000162662"
FT   ACT_SITE        64
FT                   /evidence="ECO:0000250|UniProtKB:P0AA37"
SQ   SEQUENCE   250 AA;  28897 MW;  D79DD2249A40C053 CRC64;
     MAMLEYLPPT DPWTEIIFED DHILAVNKPS GLLSVPGRLP EHHDSMWSRL QEQYPEIQVV
     HRLDMSTSGL MVFAKNKRAE AALKKQFQYR LTHKVYYARV WGHVEADSGM IDLPLICDWP
     NRPMQKVCHE HGKPSQTAFQ VAKREVHANG AQTTIMRLLP VTGRSHQLRV HMQALGHPIV
     GDEFYAQGDA FTFSERLELH AAELSFYHPK SHWLRSLFVP CDFYPDAEEM IFSYFDPARK
     LPDYKSLPKS
 
 
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