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RLUC_BUCBP
ID   RLUC_BUCBP              Reviewed;         315 AA.
AC   Q89AH2;
DT   29-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Ribosomal large subunit pseudouridine synthase C;
DE            EC=5.4.99.24;
DE   AltName: Full=23S rRNA pseudouridine(955/2504/2580) synthase;
DE   AltName: Full=rRNA pseudouridylate synthase C;
DE   AltName: Full=rRNA-uridine isomerase C;
GN   Name=rluC; OrderedLocusNames=bbp_318;
OS   Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Buchnera.
OX   NCBI_TaxID=224915;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bp;
RX   PubMed=12522265; DOI=10.1073/pnas.0235981100;
RA   van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F.,
RA   Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J.,
RA   Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A.;
RT   "Reductive genome evolution in Buchnera aphidicola.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003).
CC   -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil at
CC       positions 955, 2504 and 2580 in 23S ribosomal RNA. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=uridine(955/2504/2580) in 23S rRNA =
CC         pseudouridine(955/2504/2580) in 23S rRNA; Xref=Rhea:RHEA:42528,
CC         Rhea:RHEA-COMP:10099, Rhea:RHEA-COMP:10100, ChEBI:CHEBI:65314,
CC         ChEBI:CHEBI:65315; EC=5.4.99.24;
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC       {ECO:0000305}.
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DR   EMBL; AE016826; AAO27040.1; -; Genomic_DNA.
DR   RefSeq; WP_011091441.1; NC_004545.1.
DR   AlphaFoldDB; Q89AH2; -.
DR   SMR; Q89AH2; -.
DR   STRING; 224915.bbp_318; -.
DR   EnsemblBacteria; AAO27040; AAO27040; bbp_318.
DR   GeneID; 56470857; -.
DR   KEGG; bab:bbp_318; -.
DR   eggNOG; COG0564; Bacteria.
DR   HOGENOM; CLU_016902_1_1_6; -.
DR   OMA; PKTHVYR; -.
DR   OrthoDB; 1714699at2; -.
DR   Proteomes; UP000000601; Chromosome.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0120159; F:rRNA pseudouridine synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000455; P:enzyme-directed rRNA pseudouridine synthesis; IEA:UniProt.
DR   CDD; cd02869; PseudoU_synth_RluA_like; 1.
DR   CDD; cd00165; S4; 1.
DR   Gene3D; 3.10.290.10; -; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR   InterPro; IPR006225; PsdUridine_synth_RluC/D.
DR   InterPro; IPR006224; PsdUridine_synth_RluC/D_CS.
DR   InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR   InterPro; IPR002942; S4_RNA-bd.
DR   InterPro; IPR036986; S4_RNA-bd_sf.
DR   Pfam; PF00849; PseudoU_synth_2; 1.
DR   SUPFAM; SSF55120; SSF55120; 1.
DR   TIGRFAMs; TIGR00005; rluA_subfam; 1.
DR   PROSITE; PS01129; PSI_RLU; 1.
DR   PROSITE; PS50889; S4; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome; RNA-binding; rRNA processing.
FT   CHAIN           1..315
FT                   /note="Ribosomal large subunit pseudouridine synthase C"
FT                   /id="PRO_0000162666"
FT   DOMAIN          20..90
FT                   /note="S4 RNA-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00182"
FT   ACT_SITE        144
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   315 AA;  36992 MW;  B63DCD2C3F172CE0 CRC64;
     MTNQFSSTHF LNITENSEKQ RIDNFLRKTF KRLPFNLICK IIRTGQIRIN KKRINQNYKL
     KLGDSVRIPP ITIQSDSNKK IKLNTRLSII FNNMILYEDN YFLILNKPSG MSVHSGSGIN
     YGMIENLRIL RPYNRYLDLV HRLDRDTSGV LIIAKKRSIL RNLHEQLREK KIKKKYVALV
     HGVWPDILKS ISKPLLKTSS RKNKNIVKID PKGKESITHF NIKKKYTKNT LISITPITGR
     THQIRVHLLH LNYPIVLDAK YGIKKLDYFI KNKFNINRLL LHAESINFFH PKRKKNILIT
     APLDYVFKTV LKNLI
 
 
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