ID   RLUC_HAEDU              Reviewed;         320 AA.
AC   P59835;
DT   29-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   29-AUG-2003, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Ribosomal large subunit pseudouridine synthase C;
DE            EC=5.4.99.24;
DE   AltName: Full=23S rRNA pseudouridine(955/2504/2580) synthase;
DE   AltName: Full=rRNA pseudouridylate synthase C;
DE   AltName: Full=rRNA-uridine isomerase C;
GN   Name=rluC; OrderedLocusNames=HD_0645;
OS   Haemophilus ducreyi (strain 35000HP / ATCC 700724).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=233412;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=35000HP / ATCC 700724;
RA   Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L.,
RA   Nguyen D., Wang J., Forst C., Hood L.;
RT   "The complete genome sequence of Haemophilus ducreyi.";
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil at
CC       positions 955, 2504 and 2580 in 23S ribosomal RNA. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=uridine(955/2504/2580) in 23S rRNA =
CC         pseudouridine(955/2504/2580) in 23S rRNA; Xref=Rhea:RHEA:42528,
CC         Rhea:RHEA-COMP:10099, Rhea:RHEA-COMP:10100, ChEBI:CHEBI:65314,
CC         ChEBI:CHEBI:65315; EC=5.4.99.24;
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE017143; AAP95570.1; -; Genomic_DNA.
DR   RefSeq; WP_010944623.1; NC_002940.2.
DR   AlphaFoldDB; P59835; -.
DR   SMR; P59835; -.
DR   STRING; 233412.HD_0645; -.
DR   EnsemblBacteria; AAP95570; AAP95570; HD_0645.
DR   KEGG; hdu:HD_0645; -.
DR   eggNOG; COG0564; Bacteria.
DR   HOGENOM; CLU_016902_1_1_6; -.
DR   OMA; PKTHVYR; -.
DR   Proteomes; UP000001022; Chromosome.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0120159; F:rRNA pseudouridine synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000455; P:enzyme-directed rRNA pseudouridine synthesis; IEA:UniProt.
DR   CDD; cd02869; PseudoU_synth_RluA_like; 1.
DR   CDD; cd00165; S4; 1.
DR   Gene3D; 3.10.290.10; -; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR   InterPro; IPR006225; PsdUridine_synth_RluC/D.
DR   InterPro; IPR006224; PsdUridine_synth_RluC/D_CS.
DR   InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR   InterPro; IPR002942; S4_RNA-bd.
DR   InterPro; IPR036986; S4_RNA-bd_sf.
DR   Pfam; PF00849; PseudoU_synth_2; 1.
DR   Pfam; PF01479; S4; 1.
DR   SMART; SM00363; S4; 1.
DR   SUPFAM; SSF55120; SSF55120; 1.
DR   TIGRFAMs; TIGR00005; rluA_subfam; 1.
DR   PROSITE; PS01129; PSI_RLU; 1.
DR   PROSITE; PS50889; S4; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome; RNA-binding; rRNA processing.
FT   CHAIN           1..320
FT                   /note="Ribosomal large subunit pseudouridine synthase C"
FT                   /id="PRO_0000162670"
FT   DOMAIN          23..95
FT                   /note="S4 RNA-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00182"
FT   ACT_SITE        147
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   320 AA;  36228 MW;  5A5F120040C33E32 CRC64;
     MTTEQTISAN VQFFTISDDE AGQRLDNFLL AKLKGVPKSL IYRIVRKGEV RVNKGRVKPD
     YKLQHNDIVR IPLVRVTPKN EAPISTKLNK VAELEQHILY EDDVMLVLNK PSGIGVHGGS
     GLSFGVIEAL RALRPQARFL ELVHRIDRDT SGILLVAKKR SALRALHEQL REKVVQKDYL
     ALVRGQWQAH INVIKAPLLK NELQSGERIV KVSEQGKPSE TRFSIEERYP NATLIKASPI
     TGRTHQIRVH TQYAGHPIAC DDRYGDQAFD AKLKQAGLNR LFLHAHSIRF EHPKTAEQMF
     ITAPLDHHLK TILAKLRAEK