ID   RLUC_PASMU              Reviewed;         326 AA.
AC   Q9CM51;
DT   21-FEB-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Ribosomal large subunit pseudouridine synthase C;
DE            EC=5.4.99.24;
DE   AltName: Full=23S rRNA pseudouridine(955/2504/2580) synthase;
DE   AltName: Full=rRNA pseudouridylate synthase C;
DE   AltName: Full=rRNA-uridine isomerase C;
GN   Name=rluC; OrderedLocusNames=PM0992;
OS   Pasteurella multocida (strain Pm70).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Pasteurella.
OX   NCBI_TaxID=272843;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pm70;
RX   PubMed=11248100; DOI=10.1073/pnas.051634598;
RA   May B.J., Zhang Q., Li L.L., Paustian M.L., Whittam T.S., Kapur V.;
RT   "Complete genomic sequence of Pasteurella multocida Pm70.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:3460-3465(2001).
CC   -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil at
CC       positions 955, 2504 and 2580 in 23S ribosomal RNA. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=uridine(955/2504/2580) in 23S rRNA =
CC         pseudouridine(955/2504/2580) in 23S rRNA; Xref=Rhea:RHEA:42528,
CC         Rhea:RHEA-COMP:10099, Rhea:RHEA-COMP:10100, ChEBI:CHEBI:65314,
CC         ChEBI:CHEBI:65315; EC=5.4.99.24;
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC       {ECO:0000305}.
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DR   EMBL; AE004439; AAK03076.1; -; Genomic_DNA.
DR   RefSeq; WP_005751728.1; NC_002663.1.
DR   AlphaFoldDB; Q9CM51; -.
DR   SMR; Q9CM51; -.
DR   STRING; 747.DR93_981; -.
DR   EnsemblBacteria; AAK03076; AAK03076; PM0992.
DR   KEGG; pmu:PM0992; -.
DR   PATRIC; fig|272843.6.peg.1005; -.
DR   HOGENOM; CLU_016902_1_1_6; -.
DR   OMA; PKTHVYR; -.
DR   Proteomes; UP000000809; Chromosome.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0120159; F:rRNA pseudouridine synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000455; P:enzyme-directed rRNA pseudouridine synthesis; IEA:UniProt.
DR   CDD; cd02869; PseudoU_synth_RluA_like; 1.
DR   CDD; cd00165; S4; 1.
DR   Gene3D; 3.10.290.10; -; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR   InterPro; IPR006225; PsdUridine_synth_RluC/D.
DR   InterPro; IPR006224; PsdUridine_synth_RluC/D_CS.
DR   InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR   InterPro; IPR002942; S4_RNA-bd.
DR   InterPro; IPR036986; S4_RNA-bd_sf.
DR   Pfam; PF00849; PseudoU_synth_2; 1.
DR   Pfam; PF01479; S4; 1.
DR   SMART; SM00363; S4; 1.
DR   SUPFAM; SSF55120; SSF55120; 1.
DR   TIGRFAMs; TIGR00005; rluA_subfam; 1.
DR   PROSITE; PS01129; PSI_RLU; 1.
DR   PROSITE; PS50889; S4; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome; RNA-binding; rRNA processing.
FT   CHAIN           1..326
FT                   /note="Ribosomal large subunit pseudouridine synthase C"
FT                   /id="PRO_0000162672"
FT   DOMAIN          26..98
FT                   /note="S4 RNA-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00182"
FT   ACT_SITE        150
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   326 AA;  37101 MW;  E82DB5C555C29913 CRC64;
     MNQKKDEKVI NQAVKMLTIS EDEAGQRIDN YLLAKLKGVP KSLIYRILRK GEVRVNKGRI
     KPEYKLQAND IVRVPPVRVS EKEHAPISTK LNKVSQLEKQ ILFEDECLLV LNKPSGIAVH
     GGSGLSFGVI EALRTLRPDA RFLELVHRLD RDTSGILLVA KKRSALRSLH EQLREKTVQK
     DYLALVRGQW QSHCKVVKAP LLKNELSSGE RIVRVSEQGK PSETRFSIEE RYEYATLVKA
     SPVTGRTHQI RVHTQYAGHP IALDDKYGDK HFDEQMTQLG LTRLFLHAFS IRFEHPKTGE
     TLRINAPLDP EMKKILGALR EQKSSN