ID   RLUC_RICBR              Reviewed;         301 AA.
AC   Q1RJX7;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Ribosomal large subunit pseudouridine synthase C;
DE            EC=5.4.99.24;
DE   AltName: Full=23S rRNA pseudouridine(955/2504/2580) synthase;
DE   AltName: Full=rRNA pseudouridylate synthase C;
DE   AltName: Full=rRNA-uridine isomerase C;
GN   Name=rluC; OrderedLocusNames=RBE_0256;
OS   Rickettsia bellii (strain RML369-C).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; belli group.
OX   NCBI_TaxID=336407;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RML369-C;
RX   PubMed=16703114; DOI=10.1371/journal.pgen.0020076;
RA   Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C.,
RA   Fournier P.-E., Claverie J.-M., Raoult D.;
RT   "Genome sequence of Rickettsia bellii illuminates the role of amoebae in
RT   gene exchanges between intracellular pathogens.";
RL   PLoS Genet. 2:733-744(2006).
CC   -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil at
CC       positions 955, 2504 and 2580 in 23S ribosomal RNA. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=uridine(955/2504/2580) in 23S rRNA =
CC         pseudouridine(955/2504/2580) in 23S rRNA; Xref=Rhea:RHEA:42528,
CC         Rhea:RHEA-COMP:10099, Rhea:RHEA-COMP:10100, ChEBI:CHEBI:65314,
CC         ChEBI:CHEBI:65315; EC=5.4.99.24;
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC       {ECO:0000305}.
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DR   EMBL; CP000087; ABE04337.1; -; Genomic_DNA.
DR   RefSeq; WP_011476949.1; NC_007940.1.
DR   AlphaFoldDB; Q1RJX7; -.
DR   SMR; Q1RJX7; -.
DR   STRING; 336407.RBE_0256; -.
DR   PRIDE; Q1RJX7; -.
DR   EnsemblBacteria; ABE04337; ABE04337; RBE_0256.
DR   KEGG; rbe:RBE_0256; -.
DR   eggNOG; COG0564; Bacteria.
DR   HOGENOM; CLU_016902_1_2_5; -.
DR   OMA; PKTHVYR; -.
DR   OrthoDB; 1714699at2; -.
DR   Proteomes; UP000001951; Chromosome.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0120159; F:rRNA pseudouridine synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000455; P:enzyme-directed rRNA pseudouridine synthesis; IEA:UniProt.
DR   CDD; cd02869; PseudoU_synth_RluA_like; 1.
DR   CDD; cd00165; S4; 1.
DR   Gene3D; 3.10.290.10; -; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR   InterPro; IPR006224; PsdUridine_synth_RluC/D_CS.
DR   InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR   InterPro; IPR002942; S4_RNA-bd.
DR   InterPro; IPR036986; S4_RNA-bd_sf.
DR   Pfam; PF00849; PseudoU_synth_2; 1.
DR   Pfam; PF01479; S4; 1.
DR   SMART; SM00363; S4; 1.
DR   SUPFAM; SSF55120; SSF55120; 1.
DR   PROSITE; PS01129; PSI_RLU; 1.
DR   PROSITE; PS50889; S4; 1.
PE   3: Inferred from homology;
KW   Isomerase; RNA-binding; rRNA processing.
FT   CHAIN           1..301
FT                   /note="Ribosomal large subunit pseudouridine synthase C"
FT                   /id="PRO_0000286664"
FT   DOMAIN          11..70
FT                   /note="S4 RNA-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00182"
FT   ACT_SITE        140
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   301 AA;  33932 MW;  8B2751DF8A02902A CRC64;
     MIITVNSPIA SRLDKYLRRL YPLLTQGVIE KALRQKQIIV NSKKAEASLR VVEGDEIFIH
     DKFNLPIAQP TKLVFTDAEI TLAKKITTEY LIYEDDNIIA INKPAGLATQ GGSKINLSVD
     SALKYLNSQG ADFKLVHRLD KETSGLLLIA KNYVSSVKLH DAFKEKLVEK TYLAVTYGKP
     IKDQGEVKTN IEKSKGSIPK ITDINDNNGK LAITYYKLLK SLTNNLFLVE FIPITGRMHQ
     LRLHAKLLGC PIFGDNKYGN DKLMPYSKYM FLHANNIVLS KKVFGKEVNL EAKLPSYFNR
     V