ID   RLUC_RICCN              Reviewed;         303 AA.
AC   Q92IS6;
DT   21-FEB-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Ribosomal large subunit pseudouridine synthase C;
DE            EC=5.4.99.24;
DE   AltName: Full=23S rRNA pseudouridine(955/2504/2580) synthase;
DE   AltName: Full=rRNA pseudouridylate synthase C;
DE   AltName: Full=rRNA-uridine isomerase C;
GN   Name=rluC; OrderedLocusNames=RC0344;
OS   Rickettsia conorii (strain ATCC VR-613 / Malish 7).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=272944;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-613 / Malish 7;
RX   PubMed=11557893; DOI=10.1126/science.1061471;
RA   Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V.,
RA   Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.;
RT   "Mechanisms of evolution in Rickettsia conorii and R. prowazekii.";
RL   Science 293:2093-2098(2001).
CC   -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil at
CC       positions 955, 2504 and 2580 in 23S ribosomal RNA. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=uridine(955/2504/2580) in 23S rRNA =
CC         pseudouridine(955/2504/2580) in 23S rRNA; Xref=Rhea:RHEA:42528,
CC         Rhea:RHEA-COMP:10099, Rhea:RHEA-COMP:10100, ChEBI:CHEBI:65314,
CC         ChEBI:CHEBI:65315; EC=5.4.99.24;
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC       {ECO:0000305}.
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DR   EMBL; AE006914; AAL02882.1; -; Genomic_DNA.
DR   PIR; H97742; H97742.
DR   RefSeq; WP_010976999.1; NC_003103.1.
DR   AlphaFoldDB; Q92IS6; -.
DR   SMR; Q92IS6; -.
DR   EnsemblBacteria; AAL02882; AAL02882; RC0344.
DR   KEGG; rco:RC0344; -.
DR   PATRIC; fig|272944.4.peg.392; -.
DR   HOGENOM; CLU_016902_1_2_5; -.
DR   OMA; PKTHVYR; -.
DR   Proteomes; UP000000816; Chromosome.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0120159; F:rRNA pseudouridine synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000455; P:enzyme-directed rRNA pseudouridine synthesis; IEA:UniProt.
DR   CDD; cd02869; PseudoU_synth_RluA_like; 1.
DR   CDD; cd00165; S4; 1.
DR   Gene3D; 3.10.290.10; -; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR   InterPro; IPR006224; PsdUridine_synth_RluC/D_CS.
DR   InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR   InterPro; IPR002942; S4_RNA-bd.
DR   InterPro; IPR036986; S4_RNA-bd_sf.
DR   Pfam; PF00849; PseudoU_synth_2; 1.
DR   Pfam; PF01479; S4; 1.
DR   SMART; SM00363; S4; 1.
DR   SUPFAM; SSF55120; SSF55120; 1.
DR   PROSITE; PS01129; PSI_RLU; 1.
DR   PROSITE; PS50889; S4; 1.
PE   3: Inferred from homology;
KW   Isomerase; RNA-binding; rRNA processing.
FT   CHAIN           1..303
FT                   /note="Ribosomal large subunit pseudouridine synthase C"
FT                   /id="PRO_0000162674"
FT   DOMAIN          11..70
FT                   /note="S4 RNA-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00182"
FT   ACT_SITE        140
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   303 AA;  34267 MW;  E2A11926E0AA1D8C CRC64;
     MIIDVNTPIS SRLDKYLKRL YPLLTQGVIE KALRQKQITV NAQKAEASLR VKGGDKIFIN
     DKFNLPVKQP EKLVFTDAEI KLAKKITTDY LIYADDNLIA INKPAGLATQ GGTKINLSID
     SALKYLNYKG ADFKLVHRLD KKTSGLLLIA KNYLSSVKLH NAFKEKLVVK TYFAVTYGKP
     IKNVGEVRSN IEKSKGSTPK ITDIDSENGK LAITYYKVLK SLDNNLFLIE FTPVTGRMHQ
     LRLHAKLLGC PILGDDKYGN KEIMPYSKYM FLHANNICLS EKIFGQESKL EAKLPFYFTR
     RLT