ID   RLUC_RICFE              Reviewed;         305 AA.
AC   Q4UKQ3;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Ribosomal large subunit pseudouridine synthase C;
DE            EC=5.4.99.24;
DE   AltName: Full=23S rRNA pseudouridine(955/2504/2580) synthase;
DE   AltName: Full=rRNA pseudouridylate synthase C;
DE   AltName: Full=rRNA-uridine isomerase C;
GN   Name=rluC; OrderedLocusNames=RF_1023;
OS   Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=315456;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-1525 / URRWXCal2;
RX   PubMed=15984913; DOI=10.1371/journal.pbio.0030248;
RA   Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E.,
RA   Parinello H., Claverie J.-M., Raoult D.;
RT   "The genome sequence of Rickettsia felis identifies the first putative
RT   conjugative plasmid in an obligate intracellular parasite.";
RL   PLoS Biol. 3:1-12(2005).
CC   -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil at
CC       positions 955, 2504 and 2580 in 23S ribosomal RNA. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=uridine(955/2504/2580) in 23S rRNA =
CC         pseudouridine(955/2504/2580) in 23S rRNA; Xref=Rhea:RHEA:42528,
CC         Rhea:RHEA-COMP:10099, Rhea:RHEA-COMP:10100, ChEBI:CHEBI:65314,
CC         ChEBI:CHEBI:65315; EC=5.4.99.24;
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000053; AAY61874.1; -; Genomic_DNA.
DR   RefSeq; WP_011271339.1; NC_007109.1.
DR   AlphaFoldDB; Q4UKQ3; -.
DR   SMR; Q4UKQ3; -.
DR   STRING; 315456.RF_1023; -.
DR   EnsemblBacteria; AAY61874; AAY61874; RF_1023.
DR   KEGG; rfe:RF_1023; -.
DR   eggNOG; COG0564; Bacteria.
DR   HOGENOM; CLU_016902_1_2_5; -.
DR   OMA; PKTHVYR; -.
DR   OrthoDB; 1714699at2; -.
DR   Proteomes; UP000008548; Chromosome.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0120159; F:rRNA pseudouridine synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000455; P:enzyme-directed rRNA pseudouridine synthesis; IEA:UniProt.
DR   CDD; cd02869; PseudoU_synth_RluA_like; 1.
DR   CDD; cd00165; S4; 1.
DR   Gene3D; 3.10.290.10; -; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR   InterPro; IPR006224; PsdUridine_synth_RluC/D_CS.
DR   InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR   InterPro; IPR002942; S4_RNA-bd.
DR   InterPro; IPR036986; S4_RNA-bd_sf.
DR   Pfam; PF00849; PseudoU_synth_2; 1.
DR   Pfam; PF01479; S4; 1.
DR   SMART; SM00363; S4; 1.
DR   SUPFAM; SSF55120; SSF55120; 1.
DR   PROSITE; PS01129; PSI_RLU; 1.
DR   PROSITE; PS50889; S4; 1.
PE   3: Inferred from homology;
KW   Isomerase; RNA-binding; rRNA processing.
FT   CHAIN           1..305
FT                   /note="Ribosomal large subunit pseudouridine synthase C"
FT                   /id="PRO_0000286665"
FT   DOMAIN          11..70
FT                   /note="S4 RNA-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00182"
FT   ACT_SITE        140
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   305 AA;  34611 MW;  4BD9B3F8EACFD0E2 CRC64;
     MIIDVNTPIS SRLDKYLKRL YPLLTQGVIE KALRQKQITV NSQKAEASLR VKGGDKIFIN
     DKFNLPVKQP EKLVFTDAEI KLAKKITTDY LIYEDDNLIA INKPAGLATQ GGSKINLSID
     SALKYLNYKG ADFKLVHRLD KETSGLLLIA KNYLSNVKLH DAFKEKLVVK TYFAVTYGKP
     IKNVGEVRSN IEKSKGSTPK ITDIYSENGK LAITYYKLLK SLDNNLFLIE FTPVTGRMHQ
     LRLHAKLLGC PIVGDDKYGN KEIMPYSKYM FLHANNICLS EKIFGKEINL EAKLPFYFTD
     KFVEC