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RLUC_RICPR
ID   RLUC_RICPR              Reviewed;         303 AA.
AC   Q9ZDR7;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Ribosomal large subunit pseudouridine synthase C;
DE            EC=5.4.99.24;
DE   AltName: Full=23S rRNA pseudouridine(955/2504/2580) synthase;
DE   AltName: Full=rRNA pseudouridylate synthase C;
DE   AltName: Full=rRNA-uridine isomerase C;
GN   Name=rluC; OrderedLocusNames=RP258;
OS   Rickettsia prowazekii (strain Madrid E).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; typhus group.
OX   NCBI_TaxID=272947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Madrid E;
RX   PubMed=9823893; DOI=10.1038/24094;
RA   Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T.,
RA   Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H.,
RA   Kurland C.G.;
RT   "The genome sequence of Rickettsia prowazekii and the origin of
RT   mitochondria.";
RL   Nature 396:133-140(1998).
CC   -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil at
CC       positions 955, 2504 and 2580 in 23S ribosomal RNA. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=uridine(955/2504/2580) in 23S rRNA =
CC         pseudouridine(955/2504/2580) in 23S rRNA; Xref=Rhea:RHEA:42528,
CC         Rhea:RHEA-COMP:10099, Rhea:RHEA-COMP:10100, ChEBI:CHEBI:65314,
CC         ChEBI:CHEBI:65315; EC=5.4.99.24;
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC       {ECO:0000305}.
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DR   EMBL; AJ235271; CAA14720.1; -; Genomic_DNA.
DR   PIR; F71680; F71680.
DR   RefSeq; NP_220643.1; NC_000963.1.
DR   RefSeq; WP_004596089.1; NC_000963.1.
DR   AlphaFoldDB; Q9ZDR7; -.
DR   SMR; Q9ZDR7; -.
DR   STRING; 272947.RP258; -.
DR   PRIDE; Q9ZDR7; -.
DR   EnsemblBacteria; CAA14720; CAA14720; CAA14720.
DR   GeneID; 57569386; -.
DR   KEGG; rpr:RP258; -.
DR   PATRIC; fig|272947.5.peg.265; -.
DR   eggNOG; COG0564; Bacteria.
DR   HOGENOM; CLU_016902_1_2_5; -.
DR   OMA; PKTHVYR; -.
DR   Proteomes; UP000002480; Chromosome.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0120159; F:rRNA pseudouridine synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000455; P:enzyme-directed rRNA pseudouridine synthesis; IEA:UniProt.
DR   CDD; cd02869; PseudoU_synth_RluA_like; 1.
DR   CDD; cd00165; S4; 1.
DR   Gene3D; 3.10.290.10; -; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR   InterPro; IPR006224; PsdUridine_synth_RluC/D_CS.
DR   InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR   InterPro; IPR002942; S4_RNA-bd.
DR   InterPro; IPR036986; S4_RNA-bd_sf.
DR   Pfam; PF00849; PseudoU_synth_2; 1.
DR   Pfam; PF01479; S4; 1.
DR   SMART; SM00363; S4; 1.
DR   SUPFAM; SSF55120; SSF55120; 1.
DR   PROSITE; PS01129; PSI_RLU; 1.
DR   PROSITE; PS50889; S4; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome; RNA-binding; rRNA processing.
FT   CHAIN           1..303
FT                   /note="Ribosomal large subunit pseudouridine synthase C"
FT                   /id="PRO_0000162675"
FT   DOMAIN          11..87
FT                   /note="S4 RNA-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00182"
FT   ACT_SITE        140
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   303 AA;  34702 MW;  0264EA9D0B6B041B CRC64;
     MIIDVNIPIP FRLDKYLKRL YPLLTQGVIE KALRQKQITV NFQKAEANLR VKVGDTIFIN
     DYFNLPVTQH ETLVFADAEI KLAKKILTDY LIYEDDHLIA INKPASLATQ GGSKINLSID
     SALKYLNYQG ADFKLVHRLD KETSGLLLIA KNYLSSVKLH NAFKEKLVIK KYFAITYGRP
     VKNVGTVKSN IGKSKRRLSK IANIDSDDGK LAITYYKLLK SLNNNLFLIE FMPVTGRMHQ
     LRLHAQLLGC PILGDDKYGN KEIMPYSKYM FLHANNIYLS ETIVGKEIKL EAKLPFYFTR
     RII
 
 
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