RLUC_RICTY
ID RLUC_RICTY Reviewed; 303 AA.
AC Q68XB2;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Ribosomal large subunit pseudouridine synthase C;
DE EC=5.4.99.24;
DE AltName: Full=23S rRNA pseudouridine(955/2504/2580) synthase;
DE AltName: Full=rRNA pseudouridylate synthase C;
DE AltName: Full=rRNA-uridine isomerase C;
GN Name=rluC; OrderedLocusNames=RT0249;
OS Rickettsia typhi (strain ATCC VR-144 / Wilmington).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC Rickettsiaceae; Rickettsieae; Rickettsia; typhus group.
OX NCBI_TaxID=257363;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC VR-144 / Wilmington;
RX PubMed=15317790; DOI=10.1128/jb.186.17.5842-5855.2004;
RA McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E.,
RA McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E.,
RA Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A., Hong C.,
RA Yu X.-J., Walker D.H., Weinstock G.M.;
RT "Complete genome sequence of Rickettsia typhi and comparison with sequences
RT of other Rickettsiae.";
RL J. Bacteriol. 186:5842-5855(2004).
CC -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil at
CC positions 955, 2504 and 2580 in 23S ribosomal RNA. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=uridine(955/2504/2580) in 23S rRNA =
CC pseudouridine(955/2504/2580) in 23S rRNA; Xref=Rhea:RHEA:42528,
CC Rhea:RHEA-COMP:10099, Rhea:RHEA-COMP:10100, ChEBI:CHEBI:65314,
CC ChEBI:CHEBI:65315; EC=5.4.99.24;
CC -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC {ECO:0000305}.
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DR EMBL; AE017197; AAU03730.1; -; Genomic_DNA.
DR RefSeq; WP_011190715.1; NC_006142.1.
DR AlphaFoldDB; Q68XB2; -.
DR SMR; Q68XB2; -.
DR STRING; 257363.RT0249; -.
DR EnsemblBacteria; AAU03730; AAU03730; RT0249.
DR KEGG; rty:RT0249; -.
DR eggNOG; COG0564; Bacteria.
DR HOGENOM; CLU_016902_1_2_5; -.
DR OMA; PKTHVYR; -.
DR OrthoDB; 1714699at2; -.
DR Proteomes; UP000000604; Chromosome.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0120159; F:rRNA pseudouridine synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0000455; P:enzyme-directed rRNA pseudouridine synthesis; IEA:UniProt.
DR CDD; cd02869; PseudoU_synth_RluA_like; 1.
DR CDD; cd00165; S4; 1.
DR Gene3D; 3.10.290.10; -; 1.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR006224; PsdUridine_synth_RluC/D_CS.
DR InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR InterPro; IPR002942; S4_RNA-bd.
DR InterPro; IPR036986; S4_RNA-bd_sf.
DR Pfam; PF00849; PseudoU_synth_2; 1.
DR Pfam; PF01479; S4; 1.
DR SMART; SM00363; S4; 1.
DR SUPFAM; SSF55120; SSF55120; 1.
DR PROSITE; PS01129; PSI_RLU; 1.
DR PROSITE; PS50889; S4; 1.
PE 3: Inferred from homology;
KW Isomerase; RNA-binding; rRNA processing.
FT CHAIN 1..303
FT /note="Ribosomal large subunit pseudouridine synthase C"
FT /id="PRO_0000286666"
FT DOMAIN 11..70
FT /note="S4 RNA-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00182"
FT ACT_SITE 140
FT /evidence="ECO:0000250"
SQ SEQUENCE 303 AA; 34662 MW; 1E80BF92A819B1A1 CRC64;
MIIDVNTPIP FRLDKYLKRL YPSLTQGVIE KALRQKQVTV NFQKAEANLR VKEGDTIFIN
DYFNLPVTQH ETLVFADAEI KLAKKILTDY LIYEDDHLIA INKPASLATQ GGSKINLSID
SALKYLNYQG ADFKLVHRLD KETSGLLLIA KNYLSSVKLH DAFKEKLVIK KYFAITYGRP
VKNVGIVKSN IGKSKGRMFK ITDIDSDNGK LAITYYKLLK SLNNNLFLIE FMPVTGRMHQ
LRLHAQLLGC PILGDDKYGN KEVMPYSKYM FLHANNIYLS ESIVGKEIKL EAKLPFYFTR
RLT
