ID   RLUC_YERPE              Reviewed;         320 AA.
AC   Q8ZFU1; Q0WGI6; Q8D0Q8;
DT   29-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 125.
DE   RecName: Full=Ribosomal large subunit pseudouridine synthase C;
DE            EC=5.4.99.24;
DE   AltName: Full=23S rRNA pseudouridine(955/2504/2580) synthase;
DE   AltName: Full=rRNA pseudouridylate synthase C;
DE   AltName: Full=rRNA-uridine isomerase C;
GN   Name=rluC; OrderedLocusNames=YPO1591, y1750, YP_2262;
OS   Yersinia pestis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CO-92 / Biovar Orientalis;
RX   PubMed=11586360; DOI=10.1038/35097083;
RA   Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA   Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA   Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA   Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA   Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA   Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA   Stevens K., Whitehead S., Barrell B.G.;
RT   "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL   Nature 413:523-527(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KIM10+ / Biovar Mediaevalis;
RX   PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA   Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA   Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA   Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA   Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT   "Genome sequence of Yersinia pestis KIM.";
RL   J. Bacteriol. 184:4601-4611(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=91001 / Biovar Mediaevalis;
RX   PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA   Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA   Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA   Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA   Wang J., Huang P., Yang R.;
RT   "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT   avirulent to humans.";
RL   DNA Res. 11:179-197(2004).
CC   -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil at
CC       positions 955, 2504 and 2580 in 23S ribosomal RNA. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=uridine(955/2504/2580) in 23S rRNA =
CC         pseudouridine(955/2504/2580) in 23S rRNA; Xref=Rhea:RHEA:42528,
CC         Rhea:RHEA-COMP:10099, Rhea:RHEA-COMP:10100, ChEBI:CHEBI:65314,
CC         ChEBI:CHEBI:65315; EC=5.4.99.24;
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAM85318.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AL590842; CAL20236.1; -; Genomic_DNA.
DR   EMBL; AE009952; AAM85318.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AE017042; AAS62468.1; -; Genomic_DNA.
DR   PIR; AB0194; AB0194.
DR   RefSeq; WP_002210927.1; NZ_WUCM01000105.1.
DR   RefSeq; YP_002346602.1; NC_003143.1.
DR   AlphaFoldDB; Q8ZFU1; -.
DR   SMR; Q8ZFU1; -.
DR   STRING; 214092.YPO1591; -.
DR   PaxDb; Q8ZFU1; -.
DR   EnsemblBacteria; AAM85318; AAM85318; y1750.
DR   EnsemblBacteria; AAS62468; AAS62468; YP_2262.
DR   GeneID; 57976980; -.
DR   KEGG; ype:YPO1591; -.
DR   KEGG; ypk:y1750; -.
DR   KEGG; ypm:YP_2262; -.
DR   PATRIC; fig|214092.21.peg.1934; -.
DR   eggNOG; COG0564; Bacteria.
DR   HOGENOM; CLU_016902_1_1_6; -.
DR   OMA; PKTHVYR; -.
DR   Proteomes; UP000000815; Chromosome.
DR   Proteomes; UP000001019; Chromosome.
DR   Proteomes; UP000002490; Chromosome.
DR   GO; GO:0009982; F:pseudouridine synthase activity; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0120159; F:rRNA pseudouridine synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000455; P:enzyme-directed rRNA pseudouridine synthesis; IBA:GO_Central.
DR   CDD; cd02869; PseudoU_synth_RluA_like; 1.
DR   CDD; cd00165; S4; 1.
DR   Gene3D; 3.10.290.10; -; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR   InterPro; IPR006225; PsdUridine_synth_RluC/D.
DR   InterPro; IPR006224; PsdUridine_synth_RluC/D_CS.
DR   InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR   InterPro; IPR002942; S4_RNA-bd.
DR   InterPro; IPR036986; S4_RNA-bd_sf.
DR   Pfam; PF00849; PseudoU_synth_2; 1.
DR   Pfam; PF01479; S4; 1.
DR   SMART; SM00363; S4; 1.
DR   SUPFAM; SSF55120; SSF55120; 1.
DR   TIGRFAMs; TIGR00005; rluA_subfam; 1.
DR   PROSITE; PS01129; PSI_RLU; 1.
DR   PROSITE; PS50889; S4; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome; RNA-binding; rRNA processing.
FT   CHAIN           1..320
FT                   /note="Ribosomal large subunit pseudouridine synthase C"
FT                   /id="PRO_0000162682"
FT   DOMAIN          20..83
FT                   /note="S4 RNA-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00182"
FT   ACT_SITE        144
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   320 AA;  35970 MW;  940C517420B9F91E CRC64;
     MKTNNPVVQL ITISADEAGQ RIDNFLLAKL KGVPKSMIYR IVRKGEVRVN KGRIKPEYKL
     ADGDVVRVPP VRVAEREEVQ VSAKLDKVAA LADCILFEDD YLLVLNKPSG TAVHGGSGLS
     FGVIEGLRAL RPEARFLELV HRLDRDTSGV LLVAKKRSAL RSLHEQLRLK SMQKDYLALV
     RGQWQSHCKA IQAPLLKNIM QSGERVVKVS SEGKPSETRF KIEERFEHAT LVKASPVTGR
     THQIRVHALH AGHPIAFDDR YGYREFDQQL QGTGLHRLFL HAAALRFEHP NTGETMRIEA
     PLDNQLRHCL LALRKNATVK