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RLUD_PSEAE
ID   RLUD_PSEAE              Reviewed;         320 AA.
AC   P33640; Q9HVN4;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   11-JAN-2001, sequence version 2.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Ribosomal large subunit pseudouridine synthase D;
DE            EC=5.4.99.23;
DE   AltName: Full=23S rRNA pseudouridine(1911/1915/1917) synthase;
DE   AltName: Full=rRNA pseudouridylate synthase D;
DE   AltName: Full=rRNA-uridine isomerase D;
GN   Name=rluD; OrderedLocusNames=PA4544;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=PA14;
RA   He J., Dolan M., Goodman H., Ausubel F.M., Rahme L.G.;
RT   "clpB and a pilus cluster in Pseudomonas aeruginosa PA14.";
RL   Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-185.
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=8097014; DOI=10.1111/j.1365-2958.1993.tb01158.x;
RA   Hobbs M., Collie E.S.R., Free P.D., Livingston S.P., Mattick J.S.;
RT   "PilS and PilR, a two-component transcriptional regulatory system
RT   controlling expression of type 4 fimbriae in Pseudomonas aeruginosa.";
RL   Mol. Microbiol. 7:669-682(1993).
CC   -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil at
CC       positions 1911, 1915 and 1917 in 23S ribosomal RNA. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=uridine(1911/1915/1917) in 23S rRNA =
CC         pseudouridine(1911/1915/1917) in 23S rRNA; Xref=Rhea:RHEA:42524,
CC         Rhea:RHEA-COMP:10097, Rhea:RHEA-COMP:10098, ChEBI:CHEBI:65314,
CC         ChEBI:CHEBI:65315; EC=5.4.99.23;
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC       {ECO:0000305}.
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DR   EMBL; AY273871; AAP81266.1; -; Genomic_DNA.
DR   EMBL; AE004091; AAG07932.1; -; Genomic_DNA.
DR   EMBL; Z12154; CAA78140.1; -; Genomic_DNA.
DR   PIR; F83077; F83077.
DR   PIR; S33675; S26602.
DR   RefSeq; NP_253234.1; NC_002516.2.
DR   RefSeq; WP_003094686.1; NZ_QZGE01000004.1.
DR   AlphaFoldDB; P33640; -.
DR   SMR; P33640; -.
DR   STRING; 287.DR97_1847; -.
DR   PaxDb; P33640; -.
DR   PRIDE; P33640; -.
DR   DNASU; 877896; -.
DR   EnsemblBacteria; AAG07932; AAG07932; PA4544.
DR   GeneID; 877896; -.
DR   KEGG; pae:PA4544; -.
DR   PATRIC; fig|208964.12.peg.4755; -.
DR   PseudoCAP; PA4544; -.
DR   HOGENOM; CLU_016902_4_0_6; -.
DR   InParanoid; P33640; -.
DR   OMA; AHPSPGW; -.
DR   PhylomeDB; P33640; -.
DR   BioCyc; PAER208964:G1FZ6-4637-MON; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0009982; F:pseudouridine synthase activity; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0120159; F:rRNA pseudouridine synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000455; P:enzyme-directed rRNA pseudouridine synthesis; IBA:GO_Central.
DR   CDD; cd02869; PseudoU_synth_RluA_like; 1.
DR   CDD; cd00165; S4; 1.
DR   Gene3D; 3.10.290.10; -; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR   InterPro; IPR006225; PsdUridine_synth_RluC/D.
DR   InterPro; IPR006224; PsdUridine_synth_RluC/D_CS.
DR   InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR   InterPro; IPR002942; S4_RNA-bd.
DR   InterPro; IPR036986; S4_RNA-bd_sf.
DR   Pfam; PF00849; PseudoU_synth_2; 1.
DR   Pfam; PF01479; S4; 1.
DR   SUPFAM; SSF55120; SSF55120; 1.
DR   TIGRFAMs; TIGR00005; rluA_subfam; 1.
DR   PROSITE; PS01129; PSI_RLU; 1.
DR   PROSITE; PS50889; S4; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome; RNA-binding; rRNA processing.
FT   CHAIN           1..320
FT                   /note="Ribosomal large subunit pseudouridine synthase D"
FT                   /id="PRO_0000162697"
FT   DOMAIN          18..90
FT                   /note="S4 RNA-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00182"
FT   ACT_SITE        138
FT                   /evidence="ECO:0000250"
FT   CONFLICT        52
FT                   /note="L -> V (in Ref. 3; CAA78140)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        303
FT                   /note="D -> E (in Ref. 1; AAP81266)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   320 AA;  35625 MW;  D769C44C1A57B30E CRC64;
     MSDMIQRAAE VPFELGGQRL DQIAAQLFPE HSRSRLAGWI KDGRLTVDGA VLRPRDIVHS
     GAQLVLEAEQ EAQGEWLAQD IELEIVYEDE HILVIDKPAG LVVHPAAGHQ DGTLLNALLY
     HVPDIANVPR AGIVHRLDKD TTGLMVVAKT LEAHTKLVAQ LQARSVSRIY EAIVIGVITS
     GGTIDAPIGR HGVQRQKMAV VDAGKVAVSH YRVLERFRAH THTRVKLETG RTHQIRVHMS
     HIGYPLVGDP VYGGRFRIPP VASQTLVQTL REFPRQALHA RFLELDHPAT GVRMKWESPL
     PEDFLWLLSL LRQDREAFVG
 
 
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