AB17B_XENTR
ID AB17B_XENTR Reviewed; 288 AA.
AC Q6DEY3;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Alpha/beta hydrolase domain-containing protein 17B {ECO:0000305};
DE Short=Abhydrolase domain-containing protein 17B {ECO:0000250|UniProtKB:Q5VST6};
DE EC=3.1.2.22 {ECO:0000250|UniProtKB:Q5VST6};
GN Name=abhd17b {ECO:0000250|UniProtKB:Q5VST6};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Hydrolyzes fatty acids from S-acylated cysteine residues in
CC proteins. {ECO:0000250|UniProtKB:Q7M759}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) +
CC hexadecanoate + L-cysteinyl-[protein]; Xref=Rhea:RHEA:19233,
CC Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:7896,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950,
CC ChEBI:CHEBI:74151; EC=3.1.2.22;
CC Evidence={ECO:0000250|UniProtKB:Q7M759};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q7M759};
CC Lipid-anchor {ECO:0000250|UniProtKB:Q7M759}; Cytoplasmic side
CC {ECO:0000250|UniProtKB:Q7M759}. Recycling endosome membrane
CC {ECO:0000250|UniProtKB:Q7M759}; Lipid-anchor
CC {ECO:0000250|UniProtKB:Q7M759}; Cytoplasmic side
CC {ECO:0000250|UniProtKB:Q7M759}. Cell projection, dendritic spine
CC {ECO:0000250|UniProtKB:Q7M759}. Postsynaptic density membrane
CC {ECO:0000250|UniProtKB:Q7M759}.
CC -!- PTM: Palmitoylated on cysteine residues located in a cysteine cluster
CC at the N-terminus which promotes membrane localization.
CC {ECO:0000250|UniProtKB:Q7M759}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. ABHD17 family.
CC {ECO:0000305}.
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DR EMBL; BC076960; AAH76960.1; -; mRNA.
DR RefSeq; NP_001005065.1; NM_001005065.1.
DR AlphaFoldDB; Q6DEY3; -.
DR SMR; Q6DEY3; -.
DR STRING; 8364.ENSXETP00000057305; -.
DR ESTHER; xentr-q6dey3; ABHD17-depalmitoylase.
DR MEROPS; S09.055; -.
DR PaxDb; Q6DEY3; -.
DR DNASU; 448619; -.
DR Ensembl; ENSXETT00000057305; ENSXETP00000057305; ENSXETG00000027472.
DR GeneID; 448619; -.
DR KEGG; xtr:448619; -.
DR CTD; 51104; -.
DR Xenbase; XB-GENE-962854; abhd17b.
DR eggNOG; KOG1552; Eukaryota.
DR HOGENOM; CLU_029375_5_4_1; -.
DR InParanoid; Q6DEY3; -.
DR OMA; CELAVDH; -.
DR OrthoDB; 691954at2759; -.
DR PhylomeDB; Q6DEY3; -.
DR TreeFam; TF314365; -.
DR Reactome; R-XTR-9648002; RAS processing.
DR Proteomes; UP000008143; Chromosome 1.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000027472; Expressed in egg cell and 12 other tissues.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.
DR GO; GO:0010008; C:endosome membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0098839; C:postsynaptic density membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055038; C:recycling endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008474; F:palmitoyl-(protein) hydrolase activity; IBA:GO_Central.
DR GO; GO:0002084; P:protein depalmitoylation; IBA:GO_Central.
DR GO; GO:0099175; P:regulation of postsynapse organization; IBA:GO_Central.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR022742; Hydrolase_4.
DR Pfam; PF12146; Hydrolase_4; 1.
DR SUPFAM; SSF53474; SSF53474; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Cell projection; Endosome; Hydrolase; Lipoprotein; Membrane;
KW Palmitate; Postsynaptic cell membrane; Reference proteome; Synapse.
FT CHAIN 1..288
FT /note="Alpha/beta hydrolase domain-containing protein 17B"
FT /id="PRO_0000281116"
FT ACT_SITE 170
FT /note="Charge relay system"
FT /evidence="ECO:0000250|UniProtKB:Q96GS6"
FT ACT_SITE 235
FT /note="Charge relay system"
FT /evidence="ECO:0000250|UniProtKB:O75608"
FT ACT_SITE 264
FT /note="Charge relay system"
FT /evidence="ECO:0000250|UniProtKB:O75608"
SQ SEQUENCE 288 AA; 32250 MW; 4976B87E02CB7DEB CRC64;
MNNLSFSELC CLFCCPPCPG KIASKLAFLP PDPTYTLICD ESGSRWTLHL SERADWQYSS
REKDAIECFM TRTSRGNRIA CMFVRCSPNA KYTLLFSHGN AVDLGQMSSF YIGLGSRINC
NIFSYDYSGY GSSSGKPSEK NLYADIDAAW IALRTRYGIR PEHVIIYGQS IGTVPSVDLA
ARYESAAVIL HSPLTSGMRV AFPDTKKTYC FDAFPNIDKI SKITSPVLII HGTEDEVIDF
SHGLALFERC QRPVEPLWVE GAGHNDVELY GQYLERLKQF VTQELVNL