RM04_BOVIN
ID RM04_BOVIN Reviewed; 294 AA.
AC Q32PI6;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=39S ribosomal protein L4, mitochondrial;
DE Short=L4mt;
DE Short=MRP-L4;
GN Name=MRPL4;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Rumen;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION, AND SUBUNIT.
RX PubMed=11279069; DOI=10.1074/jbc.m100432200;
RA Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A.,
RA Watanabe K.;
RT "Structural compensation for the deficit of rRNA with proteins in the
RT mammalian mitochondrial ribosome. Systematic analysis of protein components
RT of the large ribosomal subunit from mammalian mitochondria.";
RL J. Biol. Chem. 276:21724-21736(2001).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RX PubMed=11551941; DOI=10.1074/jbc.m106510200;
RA Koc E.C., Burkhart W., Blackburn K., Moyer M.B., Schlatzer D.M.,
RA Moseley A., Spremulli L.L.;
RT "The large subunit of the mammalian mitochondrial ribosome. Analysis of the
RT complement of ribosomal proteins present.";
RL J. Biol. Chem. 276:43958-43969(2001).
RN [4]
RP STRUCTURE BY ELECTRON MICROSCOPY (12 ANGSTROMS), AND SUBCELLULAR LOCATION.
RX PubMed=16510155; DOI=10.1016/j.jmb.2006.01.094;
RA Mears J.A., Sharma M.R., Gutell R.R., McCook A.S., Richardson P.E.,
RA Caulfield T.R., Agrawal R.K., Harvey S.C.;
RT "A structural model for the large subunit of the mammalian mitochondrial
RT ribosome.";
RL J. Mol. Biol. 358:193-212(2006).
CC -!- SUBUNIT: Component of the mitochondrial ribosome large subunit (39S)
CC which comprises a 16S rRNA and about 50 distinct proteins
CC (PubMed:11279069). Interacts with MIEF1 upstream open reading frame
CC protein (By similarity). {ECO:0000250|UniProtKB:Q9BYD3,
CC ECO:0000269|PubMed:11279069}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11279069,
CC ECO:0000269|PubMed:11551941, ECO:0000269|PubMed:16510155}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL4 family.
CC {ECO:0000305}.
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DR EMBL; BC108102; AAI08103.1; -; mRNA.
DR RefSeq; NP_001032527.1; NM_001037450.2.
DR PDB; 2FTC; EM; -; D=97-270.
DR PDBsum; 2FTC; -.
DR AlphaFoldDB; Q32PI6; -.
DR SMR; Q32PI6; -.
DR STRING; 9913.ENSBTAP00000001861; -.
DR PaxDb; Q32PI6; -.
DR PRIDE; Q32PI6; -.
DR Ensembl; ENSBTAT00000001861; ENSBTAP00000001861; ENSBTAG00000001419.
DR GeneID; 507154; -.
DR KEGG; bta:507154; -.
DR CTD; 51073; -.
DR VEuPathDB; HostDB:ENSBTAG00000001419; -.
DR VGNC; VGNC:31635; MRPL4.
DR eggNOG; KOG1624; Eukaryota.
DR GeneTree; ENSGT00950000185283; -.
DR HOGENOM; CLU_041575_3_3_1; -.
DR InParanoid; Q32PI6; -.
DR OMA; PQVHILE; -.
DR OrthoDB; 1592747at2759; -.
DR TreeFam; TF313913; -.
DR EvolutionaryTrace; Q32PI6; -.
DR Proteomes; UP000009136; Chromosome 7.
DR Bgee; ENSBTAG00000001419; Expressed in rectus femoris and 106 other tissues.
DR ExpressionAtlas; Q32PI6; baseline and differential.
DR GO; GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
DR GO; GO:0005762; C:mitochondrial large ribosomal subunit; ISS:UniProtKB.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR Gene3D; 3.40.1370.10; -; 1.
DR HAMAP; MF_01328_B; Ribosomal_L4_B; 1.
DR InterPro; IPR002136; Ribosomal_L4/L1e.
DR InterPro; IPR023574; Ribosomal_L4_dom_sf.
DR InterPro; IPR013005; Ribosomal_uL4/L1e.
DR PANTHER; PTHR10746; PTHR10746; 1.
DR Pfam; PF00573; Ribosomal_L4; 1.
DR SUPFAM; SSF52166; SSF52166; 1.
DR TIGRFAMs; TIGR03953; rplD_bact; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Methylation; Mitochondrion; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein.
FT CHAIN 1..294
FT /note="39S ribosomal protein L4, mitochondrial"
FT /id="PRO_0000238948"
FT REGION 120..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 147
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q9BYD3"
SQ SEQUENCE 294 AA; 33371 MW; 60DA55E75E29B61F CRC64;
MQQLVRAGAR AWLRPRGCRG LSALTEEAVQ SAEKPEPLAN AGPQAPVLRR CELPVPLHRR
PVQAWVESLR GYEQERVGLT ELHPDVFSTA PRLDILHQVA IWQKNFKRIS YAKTKTRAEV
RGGGRKPWQQ KGSGRARHGS IRSPIWRGGG VAHGPRGPTS YYYMLPMKVR VQGLKVALTV
KLAQDDLHIV DSLELPTTDP QYLMELARYR RWGDSVLFVD LEHEDMPQNV VAATSGLKTF
NLIPAIGLNV HSMLKHQTLV LTLPTVAFLE EKLLWHDSRY TPLYPFRLPY RDFP
