RM10_MOUSE
ID RM10_MOUSE Reviewed; 262 AA.
AC Q3TBW2; Q9CQD2;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=39S ribosomal protein L10, mitochondrial;
DE Short=L10mt;
DE Short=MRP-L10;
DE Flags: Precursor;
GN Name=Mrpl10;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Bone marrow, Kidney, and Pancreas;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Component of the mitochondrial ribosome large subunit (39S)
CC which comprises a 16S rRNA and about 50 distinct proteins.
CC {ECO:0000250|UniProtKB:Q7Z7H8}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q7Z7H8}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL10 family.
CC {ECO:0000305}.
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DR EMBL; AK002865; BAB22415.1; -; mRNA.
DR EMBL; AK007643; BAB25158.1; -; mRNA.
DR EMBL; AK150774; BAE29840.1; -; mRNA.
DR EMBL; AK171028; BAE42195.1; -; mRNA.
DR EMBL; BC016219; AAH16219.1; -; mRNA.
DR CCDS; CCDS25312.1; -.
DR RefSeq; NP_080430.1; NM_026154.1.
DR AlphaFoldDB; Q3TBW2; -.
DR SMR; Q3TBW2; -.
DR BioGRID; 223525; 26.
DR ComplexPortal; CPX-5302; 39S mitochondrial large ribosomal subunit.
DR STRING; 10090.ENSMUSP00000001485; -.
DR iPTMnet; Q3TBW2; -.
DR PhosphoSitePlus; Q3TBW2; -.
DR EPD; Q3TBW2; -.
DR jPOST; Q3TBW2; -.
DR MaxQB; Q3TBW2; -.
DR PaxDb; Q3TBW2; -.
DR PeptideAtlas; Q3TBW2; -.
DR PRIDE; Q3TBW2; -.
DR ProteomicsDB; 301601; -.
DR Antibodypedia; 17772; 177 antibodies from 25 providers.
DR DNASU; 107732; -.
DR Ensembl; ENSMUST00000001485; ENSMUSP00000001485; ENSMUSG00000001445.
DR GeneID; 107732; -.
DR KEGG; mmu:107732; -.
DR UCSC; uc007ldm.1; mouse.
DR CTD; 124995; -.
DR MGI; MGI:1333801; Mrpl10.
DR VEuPathDB; HostDB:ENSMUSG00000001445; -.
DR eggNOG; KOG4241; Eukaryota.
DR GeneTree; ENSGT00390000000603; -.
DR HOGENOM; CLU_073093_0_0_1; -.
DR InParanoid; Q3TBW2; -.
DR OMA; FHSNHCI; -.
DR OrthoDB; 1484426at2759; -.
DR PhylomeDB; Q3TBW2; -.
DR TreeFam; TF321349; -.
DR Reactome; R-MMU-5389840; Mitochondrial translation elongation.
DR Reactome; R-MMU-5419276; Mitochondrial translation termination.
DR BioGRID-ORCS; 107732; 28 hits in 74 CRISPR screens.
DR ChiTaRS; Mrpl10; mouse.
DR PRO; PR:Q3TBW2; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q3TBW2; protein.
DR Bgee; ENSMUSG00000001445; Expressed in yolk sac and 246 other tissues.
DR ExpressionAtlas; Q3TBW2; baseline and differential.
DR Genevisible; Q3TBW2; MM.
DR GO; GO:0015934; C:large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0005743; C:mitochondrial inner membrane; IC:ComplexPortal.
DR GO; GO:0005762; C:mitochondrial large ribosomal subunit; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:1990904; C:ribonucleoprotein complex; ISS:UniProtKB.
DR GO; GO:0003735; F:structural constituent of ribosome; ISS:UniProtKB.
DR GO; GO:0032543; P:mitochondrial translation; IC:ComplexPortal.
DR GO; GO:0006412; P:translation; ISS:UniProtKB.
DR CDD; cd05797; Ribosomal_L10; 1.
DR Gene3D; 3.30.70.1730; -; 1.
DR InterPro; IPR043141; Ribosomal_L10-like_sf.
DR InterPro; IPR001790; Ribosomal_L10P.
DR PANTHER; PTHR11560; PTHR11560; 1.
DR SUPFAM; SSF160369; SSF160369; 1.
PE 1: Evidence at protein level;
KW Mitochondrion; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW Transit peptide.
FT TRANSIT 1..28
FT /note="Mitochondrion"
FT /evidence="ECO:0000250"
FT CHAIN 29..262
FT /note="39S ribosomal protein L10, mitochondrial"
FT /id="PRO_0000273076"
FT REGION 243..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 141
FT /note="R -> Q (in Ref. 1; BAE42195)"
FT /evidence="ECO:0000305"
FT CONFLICT 262
FT /note="A -> S (in Ref. 1; BAE42195)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 262 AA; 29396 MW; 9C87E737E6C12E8E CRC64;
MAAAVAGILR GGLPPRAAWL PTLQTVRHGS KAVTRHWRVM HFQRQKLMAI TEYIPPKPAI
NPRCLPPPPK PPKEESGLVR LLRQDIVAVF RDNRMIAVCQ NVALSAEDKL LLRHQLRKHK
IFIKVFPSQV LKPFLENSKY RNLLPLFVGH NLLLVSEEPK VKEMVRVLKS VPFLPLLGGC
VDDTILSRQG LVDYAKLPSL DQLQGQLVGG LTHLMAQTRY LLQHQPVQLT SLLDQYVKEQ
NEGDCATSAN EKLHPPDPAP DA
