RM14_MOUSE
ID RM14_MOUSE Reviewed; 145 AA.
AC Q9D1I6; Q3UNL3;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=39S ribosomal protein L14, mitochondrial;
DE Short=L14mt;
DE Short=MRP-L14;
DE Flags: Precursor;
GN Name=Mrpl14;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Liver, and Submandibular gland;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N-3; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Heart, Kidney, Liver, Pancreas, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May form part of 2 intersubunit bridges in the assembled
CC ribosome. Upon binding to MALSU1, intersubunit bridge formation is
CC blocked, preventing ribosome formation and repressing translation.
CC {ECO:0000250|UniProtKB:Q6P1L8}.
CC -!- SUBUNIT: Component of the mitochondrial ribosome large subunit (39S)
CC which comprises a 16S rRNA and about 50 distinct proteins. Interacts
CC with MALSU1. {ECO:0000250|UniProtKB:Q6P1L8}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q6P1L8}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL14 family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK003500; BAB22824.1; -; mRNA.
DR EMBL; AK050273; BAC34158.1; -; mRNA.
DR EMBL; AK144153; BAE25734.1; -; mRNA.
DR EMBL; BC027021; AAH27021.1; -; mRNA.
DR CCDS; CCDS28815.1; -.
DR RefSeq; NP_081008.1; NM_026732.2.
DR RefSeq; XP_006524906.1; XM_006524843.2.
DR RefSeq; XP_006524907.1; XM_006524844.3.
DR AlphaFoldDB; Q9D1I6; -.
DR SMR; Q9D1I6; -.
DR BioGRID; 212863; 34.
DR ComplexPortal; CPX-5302; 39S mitochondrial large ribosomal subunit.
DR STRING; 10090.ENSMUSP00000024734; -.
DR PhosphoSitePlus; Q9D1I6; -.
DR SwissPalm; Q9D1I6; -.
DR EPD; Q9D1I6; -.
DR MaxQB; Q9D1I6; -.
DR PaxDb; Q9D1I6; -.
DR PeptideAtlas; Q9D1I6; -.
DR PRIDE; Q9D1I6; -.
DR ProteomicsDB; 260976; -.
DR Antibodypedia; 49263; 127 antibodies from 22 providers.
DR DNASU; 68463; -.
DR Ensembl; ENSMUST00000024734; ENSMUSP00000024734; ENSMUSG00000023939.
DR GeneID; 68463; -.
DR KEGG; mmu:68463; -.
DR UCSC; uc008crj.1; mouse.
DR CTD; 64928; -.
DR MGI; MGI:1333864; Mrpl14.
DR VEuPathDB; HostDB:ENSMUSG00000023939; -.
DR eggNOG; KOG3441; Eukaryota.
DR GeneTree; ENSGT00390000001121; -.
DR HOGENOM; CLU_128925_1_0_1; -.
DR InParanoid; Q9D1I6; -.
DR OMA; RCIHVYT; -.
DR OrthoDB; 1547267at2759; -.
DR PhylomeDB; Q9D1I6; -.
DR TreeFam; TF324586; -.
DR Reactome; R-MMU-5389840; Mitochondrial translation elongation.
DR Reactome; R-MMU-5419276; Mitochondrial translation termination.
DR BioGRID-ORCS; 68463; 22 hits in 75 CRISPR screens.
DR ChiTaRS; Mrpl14; mouse.
DR PRO; PR:Q9D1I6; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q9D1I6; protein.
DR Bgee; ENSMUSG00000023939; Expressed in yolk sac and 207 other tissues.
DR Genevisible; Q9D1I6; MM.
DR GO; GO:0005743; C:mitochondrial inner membrane; IC:ComplexPortal.
DR GO; GO:0005762; C:mitochondrial large ribosomal subunit; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0032543; P:mitochondrial translation; IC:ComplexPortal.
DR Gene3D; 2.40.150.20; -; 1.
DR HAMAP; MF_01367; Ribosomal_L14; 1.
DR InterPro; IPR036853; Ribosomal_L14_sf.
DR InterPro; IPR000218; Ribosomal_L14P.
DR Pfam; PF00238; Ribosomal_L14; 1.
DR SMART; SM01374; Ribosomal_L14; 1.
DR SUPFAM; SSF50193; SSF50193; 1.
PE 1: Evidence at protein level;
KW Mitochondrion; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW Transit peptide.
FT TRANSIT 1..30
FT /note="Mitochondrion"
FT /evidence="ECO:0000250"
FT CHAIN 31..145
FT /note="39S ribosomal protein L14, mitochondrial"
FT /id="PRO_0000261135"
FT CONFLICT 32..34
FT /note="VQK -> IQ (in Ref. 1; BAE25734)"
FT /evidence="ECO:0000305"
FT CONFLICT 104
FT /note="N -> S (in Ref. 1; BAE25734)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 145 AA; 15874 MW; 90D049E030897A93 CRC64;
MAALTGLWGS FAHVSRAFSQ RCFSTSGSLS AVQKMTRVRV VDNSALGSTP YHRPPRCIHV
YNKSGVGKVG DQILLAIRGQ KKKALIVGHR MPGSRMTPKF DSNNVVLIED NGNPVGTRIK
IPIPTSLRRR EGEYSKVLAI AQNFV
