RM20_MOUSE
ID RM20_MOUSE Reviewed; 149 AA.
AC Q9CQL4; Q9D5L3;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=39S ribosomal protein L20, mitochondrial;
DE Short=L20mt;
DE Short=MRP-L20;
DE Flags: Precursor;
GN Name=Mrpl20;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11279069; DOI=10.1074/jbc.m100432200;
RA Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A.,
RA Watanabe K.;
RT "Structural compensation for the deficit of rRNA with proteins in the
RT mammalian mitochondrial ribosome. Systematic analysis of protein components
RT of the large ribosomal subunit from mammalian mitochondria.";
RL J. Biol. Chem. 276:21724-21736(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Stomach, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PROTEIN SEQUENCE OF 83-92, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=OF1; TISSUE=Hippocampus;
RA Lubec G., Sunyer B., Chen W.-Q.;
RL Submitted (JAN-2009) to UniProtKB.
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Heart, Kidney, Liver, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Component of the mitochondrial ribosome large subunit (39S)
CC which comprises a 16S rRNA and about 50 distinct proteins (By
CC similarity). Interacts with OXA1L (By similarity).
CC {ECO:0000250|UniProtKB:Q2TBR2, ECO:0000250|UniProtKB:Q9BYC9}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q2TBR2}.
CC -!- SIMILARITY: Belongs to the bacterial ribosomal protein bL20 family.
CC {ECO:0000305}.
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DR EMBL; AB049645; BAB40850.1; -; mRNA.
DR EMBL; AK004053; BAB23143.1; -; mRNA.
DR EMBL; AK011341; BAB27555.1; -; mRNA.
DR EMBL; AK015199; BAB29744.1; -; mRNA.
DR EMBL; AK168665; BAE40517.1; -; mRNA.
DR EMBL; BC039985; AAH39985.1; -; mRNA.
DR CCDS; CCDS19041.1; -.
DR RefSeq; NP_079846.1; NM_025570.2.
DR RefSeq; XP_006539167.1; XM_006539104.2.
DR AlphaFoldDB; Q9CQL4; -.
DR SMR; Q9CQL4; -.
DR BioGRID; 211482; 2.
DR ComplexPortal; CPX-5302; 39S mitochondrial large ribosomal subunit.
DR STRING; 10090.ENSMUSP00000030942; -.
DR iPTMnet; Q9CQL4; -.
DR PhosphoSitePlus; Q9CQL4; -.
DR EPD; Q9CQL4; -.
DR jPOST; Q9CQL4; -.
DR MaxQB; Q9CQL4; -.
DR PaxDb; Q9CQL4; -.
DR PeptideAtlas; Q9CQL4; -.
DR PRIDE; Q9CQL4; -.
DR ProteomicsDB; 300519; -.
DR Antibodypedia; 51971; 94 antibodies from 19 providers.
DR DNASU; 66448; -.
DR Ensembl; ENSMUST00000030942; ENSMUSP00000030942; ENSMUSG00000029066.
DR Ensembl; ENSMUST00000137487; ENSMUSP00000139122; ENSMUSG00000029066.
DR GeneID; 66448; -.
DR KEGG; mmu:66448; -.
DR UCSC; uc008weu.1; mouse.
DR CTD; 55052; -.
DR MGI; MGI:2137221; Mrpl20.
DR VEuPathDB; HostDB:ENSMUSG00000029066; -.
DR eggNOG; KOG4707; Eukaryota.
DR GeneTree; ENSGT00390000015823; -.
DR HOGENOM; CLU_123265_1_1_1; -.
DR InParanoid; Q9CQL4; -.
DR OMA; GRRKNVW; -.
DR OrthoDB; 1582185at2759; -.
DR PhylomeDB; Q9CQL4; -.
DR TreeFam; TF324702; -.
DR Reactome; R-MMU-5389840; Mitochondrial translation elongation.
DR Reactome; R-MMU-5419276; Mitochondrial translation termination.
DR BioGRID-ORCS; 66448; 30 hits in 73 CRISPR screens.
DR ChiTaRS; Mrpl20; mouse.
DR PRO; PR:Q9CQL4; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q9CQL4; protein.
DR Bgee; ENSMUSG00000029066; Expressed in gastrula and 298 other tissues.
DR ExpressionAtlas; Q9CQL4; baseline and differential.
DR Genevisible; Q9CQL4; MM.
DR GO; GO:0005743; C:mitochondrial inner membrane; IC:ComplexPortal.
DR GO; GO:0005762; C:mitochondrial large ribosomal subunit; ISS:UniProtKB.
DR GO; GO:0005761; C:mitochondrial ribosome; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0019843; F:rRNA binding; IEA:InterPro.
DR GO; GO:0003735; F:structural constituent of ribosome; ISO:MGI.
DR GO; GO:0032543; P:mitochondrial translation; IC:ComplexPortal.
DR GO; GO:0000027; P:ribosomal large subunit assembly; IBA:GO_Central.
DR GO; GO:0006412; P:translation; ISO:MGI.
DR CDD; cd07026; Ribosomal_L20; 1.
DR Gene3D; 1.10.1900.20; -; 1.
DR InterPro; IPR005813; Ribosomal_L20.
DR InterPro; IPR035566; Ribosomal_protein_L20_C.
DR PANTHER; PTHR10986; PTHR10986; 1.
DR Pfam; PF00453; Ribosomal_L20; 1.
DR PRINTS; PR00062; RIBOSOMALL20.
DR SUPFAM; SSF74731; SSF74731; 1.
DR TIGRFAMs; TIGR01032; rplT_bact; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Mitochondrion; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein; Transit peptide.
FT TRANSIT 1..9
FT /note="Mitochondrion"
FT /evidence="ECO:0000250|UniProtKB:Q2TBR2"
FT CHAIN 10..149
FT /note="39S ribosomal protein L20, mitochondrial"
FT /id="PRO_0000248280"
FT CONFLICT 62
FT /note="R -> L (in Ref. 2; BAB29744)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 149 AA; 17595 MW; 7B86D8C568B633AE CRC64;
MVFLTTRLWL RNRLTDRYWR VQEVLKHAQH FRGRKNRCYR LAVRAVTRAF VKCTKARRLK
KRNLRTLWIN RITAASQEHG LKYPAFIVNL IKCQVELNRK VLVDLAIYEP KTFKSLAALA
KRRQQEGFAA ALGDGKEPEG IFSRVVQYH
