RM21_HUMAN
ID RM21_HUMAN Reviewed; 205 AA.
AC Q7Z2W9; A6NKU0; C9JPR2;
DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 2.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=39S ribosomal protein L21, mitochondrial;
DE Short=L21mt;
DE Short=MRP-L21;
DE AltName: Full=Mitochondrial large ribosomal subunit protein bL21m {ECO:0000303|PubMed:25278503};
DE Flags: Precursor;
GN Name=MRPL21;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Melanoma;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
RN [6] {ECO:0007744|PDB:3J7Y}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.40 ANGSTROMS), SUBCELLULAR LOCATION,
RP AND SUBUNIT.
RX PubMed=25278503; DOI=10.1126/science.1258026;
RA Brown A., Amunts A., Bai X.C., Sugimoto Y., Edwards P.C., Murshudov G.,
RA Scheres S.H., Ramakrishnan V.;
RT "Structure of the large ribosomal subunit from human mitochondria.";
RL Science 346:718-722(2014).
RN [7] {ECO:0007744|PDB:3J9M}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.50 ANGSTROMS), SUBCELLULAR LOCATION,
RP AND SUBUNIT.
RX PubMed=25838379; DOI=10.1126/science.aaa1193;
RA Amunts A., Brown A., Toots J., Scheres S.H., Ramakrishnan V.;
RT "Ribosome. The structure of the human mitochondrial ribosome.";
RL Science 348:95-98(2015).
RN [8] {ECO:0007744|PDB:5OOL, ECO:0007744|PDB:5OOM}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.03 ANGSTROMS), SUBCELLULAR LOCATION,
RP AND SUBUNIT.
RX PubMed=28892042; DOI=10.1038/nsmb.3464;
RA Brown A., Rathore S., Kimanius D., Aibara S., Bai X.C., Rorbach J.,
RA Amunts A., Ramakrishnan V.;
RT "Structures of the human mitochondrial ribosome in native states of
RT assembly.";
RL Nat. Struct. Mol. Biol. 24:866-869(2017).
CC -!- SUBUNIT: Component of the mitochondrial large ribosomal subunit (mt-
CC LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). Mature
CC mammalian 55S mitochondrial ribosomes consist of a small (28S) and a
CC large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA
CC (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains
CC a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA
CC (mt-tRNA(Val)), which plays an integral structural role, and 52
CC different proteins. {ECO:0000269|PubMed:25278503,
CC ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503,
CC ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q7Z2W9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7Z2W9-2; Sequence=VSP_045633;
CC -!- SIMILARITY: Belongs to the bacterial ribosomal protein bL21 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH55088.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AP000808; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471076; EAW74724.1; -; Genomic_DNA.
DR EMBL; BC055088; AAH55088.1; ALT_INIT; mRNA.
DR EMBL; BM915440; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS44662.1; -. [Q7Z2W9-2]
DR CCDS; CCDS8186.1; -. [Q7Z2W9-1]
DR RefSeq; NP_852615.1; NM_181514.1. [Q7Z2W9-1]
DR RefSeq; NP_852616.1; NM_181515.1. [Q7Z2W9-2]
DR PDB; 3J7Y; EM; 3.40 A; S=1-205.
DR PDB; 3J9M; EM; 3.50 A; S=1-205.
DR PDB; 5OOL; EM; 3.06 A; S=1-205.
DR PDB; 5OOM; EM; 3.03 A; S=1-205.
DR PDB; 6I9R; EM; 3.90 A; S=1-205.
DR PDB; 6NU2; EM; 3.90 A; S=49-204.
DR PDB; 6NU3; EM; 4.40 A; S=1-205.
DR PDB; 6VLZ; EM; 2.97 A; S=1-205.
DR PDB; 6VMI; EM; 2.96 A; S=1-205.
DR PDB; 6ZM5; EM; 2.89 A; S=1-205.
DR PDB; 6ZM6; EM; 2.59 A; S=1-205.
DR PDB; 6ZS9; EM; 4.00 A; XS=1-205.
DR PDB; 6ZSA; EM; 4.00 A; XS=1-205.
DR PDB; 6ZSB; EM; 4.50 A; XS=1-205.
DR PDB; 6ZSC; EM; 3.50 A; XS=1-205.
DR PDB; 6ZSD; EM; 3.70 A; XS=1-205.
DR PDB; 6ZSE; EM; 5.00 A; XS=1-205.
DR PDB; 6ZSG; EM; 4.00 A; XS=1-205.
DR PDB; 7A5F; EM; 4.40 A; S3=1-205.
DR PDB; 7A5G; EM; 4.33 A; S3=1-205.
DR PDB; 7A5H; EM; 3.30 A; S=1-205.
DR PDB; 7A5I; EM; 3.70 A; S3=1-205.
DR PDB; 7A5J; EM; 3.10 A; S=1-205.
DR PDB; 7A5K; EM; 3.70 A; S3=1-205.
DR PDB; 7L08; EM; 3.49 A; S=1-205.
DR PDB; 7L20; EM; 3.15 A; S=1-205.
DR PDB; 7O9K; EM; 3.10 A; S=1-205.
DR PDB; 7O9M; EM; 2.50 A; S=1-205.
DR PDB; 7ODR; EM; 2.90 A; S=1-205.
DR PDB; 7ODS; EM; 3.10 A; S=1-205.
DR PDB; 7ODT; EM; 3.10 A; S=1-205.
DR PDB; 7OF0; EM; 2.20 A; S=1-205.
DR PDB; 7OF2; EM; 2.70 A; S=1-205.
DR PDB; 7OF3; EM; 2.70 A; S=1-205.
DR PDB; 7OF4; EM; 2.70 A; S=1-205.
DR PDB; 7OF5; EM; 2.90 A; S=1-205.
DR PDB; 7OF6; EM; 2.60 A; S=1-205.
DR PDB; 7OF7; EM; 2.50 A; S=1-205.
DR PDB; 7OG4; EM; 3.80 A; XS=1-205.
DR PDB; 7OI6; EM; 5.70 A; S=1-205.
DR PDB; 7OI7; EM; 3.50 A; S=1-205.
DR PDB; 7OI8; EM; 3.50 A; S=1-205.
DR PDB; 7OI9; EM; 3.30 A; S=1-205.
DR PDB; 7OIA; EM; 3.20 A; S=1-205.
DR PDB; 7OIB; EM; 3.30 A; S=1-205.
DR PDB; 7OIC; EM; 3.10 A; S=1-205.
DR PDB; 7OID; EM; 3.70 A; S=1-205.
DR PDB; 7OIE; EM; 3.50 A; S=1-205.
DR PDB; 7PD3; EM; 3.40 A; S=1-205.
DR PDB; 7QH6; EM; 3.08 A; S=1-205.
DR PDBsum; 3J7Y; -.
DR PDBsum; 3J9M; -.
DR PDBsum; 5OOL; -.
DR PDBsum; 5OOM; -.
DR PDBsum; 6I9R; -.
DR PDBsum; 6NU2; -.
DR PDBsum; 6NU3; -.
DR PDBsum; 6VLZ; -.
DR PDBsum; 6VMI; -.
DR PDBsum; 6ZM5; -.
DR PDBsum; 6ZM6; -.
DR PDBsum; 6ZS9; -.
DR PDBsum; 6ZSA; -.
DR PDBsum; 6ZSB; -.
DR PDBsum; 6ZSC; -.
DR PDBsum; 6ZSD; -.
DR PDBsum; 6ZSE; -.
DR PDBsum; 6ZSG; -.
DR PDBsum; 7A5F; -.
DR PDBsum; 7A5G; -.
DR PDBsum; 7A5H; -.
DR PDBsum; 7A5I; -.
DR PDBsum; 7A5J; -.
DR PDBsum; 7A5K; -.
DR PDBsum; 7L08; -.
DR PDBsum; 7L20; -.
DR PDBsum; 7O9K; -.
DR PDBsum; 7O9M; -.
DR PDBsum; 7ODR; -.
DR PDBsum; 7ODS; -.
DR PDBsum; 7ODT; -.
DR PDBsum; 7OF0; -.
DR PDBsum; 7OF2; -.
DR PDBsum; 7OF3; -.
DR PDBsum; 7OF4; -.
DR PDBsum; 7OF5; -.
DR PDBsum; 7OF6; -.
DR PDBsum; 7OF7; -.
DR PDBsum; 7OG4; -.
DR PDBsum; 7OI6; -.
DR PDBsum; 7OI7; -.
DR PDBsum; 7OI8; -.
DR PDBsum; 7OI9; -.
DR PDBsum; 7OIA; -.
DR PDBsum; 7OIB; -.
DR PDBsum; 7OIC; -.
DR PDBsum; 7OID; -.
DR PDBsum; 7OIE; -.
DR PDBsum; 7PD3; -.
DR PDBsum; 7QH6; -.
DR AlphaFoldDB; Q7Z2W9; -.
DR SMR; Q7Z2W9; -.
DR BioGRID; 128594; 184.
DR ComplexPortal; CPX-5226; 39S mitochondrial large ribosomal subunit.
DR CORUM; Q7Z2W9; -.
DR IntAct; Q7Z2W9; 47.
DR MINT; Q7Z2W9; -.
DR STRING; 9606.ENSP00000354580; -.
DR iPTMnet; Q7Z2W9; -.
DR PhosphoSitePlus; Q7Z2W9; -.
DR BioMuta; MRPL21; -.
DR DMDM; 229462820; -.
DR EPD; Q7Z2W9; -.
DR jPOST; Q7Z2W9; -.
DR MassIVE; Q7Z2W9; -.
DR MaxQB; Q7Z2W9; -.
DR PaxDb; Q7Z2W9; -.
DR PeptideAtlas; Q7Z2W9; -.
DR PRIDE; Q7Z2W9; -.
DR ProteomicsDB; 11149; -.
DR ProteomicsDB; 68979; -. [Q7Z2W9-1]
DR Antibodypedia; 30611; 147 antibodies from 22 providers.
DR DNASU; 219927; -.
DR Ensembl; ENST00000362034.7; ENSP00000354580.2; ENSG00000197345.13. [Q7Z2W9-1]
DR Ensembl; ENST00000450904.6; ENSP00000389400.2; ENSG00000197345.13. [Q7Z2W9-2]
DR GeneID; 219927; -.
DR KEGG; hsa:219927; -.
DR MANE-Select; ENST00000362034.7; ENSP00000354580.2; NM_181514.2; NP_852615.1.
DR UCSC; uc001ooh.4; human. [Q7Z2W9-1]
DR CTD; 219927; -.
DR DisGeNET; 219927; -.
DR GeneCards; MRPL21; -.
DR HGNC; HGNC:14479; MRPL21.
DR HPA; ENSG00000197345; Low tissue specificity.
DR MIM; 611834; gene.
DR neXtProt; NX_Q7Z2W9; -.
DR OpenTargets; ENSG00000197345; -.
DR PharmGKB; PA30951; -.
DR VEuPathDB; HostDB:ENSG00000197345; -.
DR eggNOG; KOG1686; Eukaryota.
DR GeneTree; ENSGT00390000005535; -.
DR HOGENOM; CLU_061463_5_2_1; -.
DR InParanoid; Q7Z2W9; -.
DR OMA; DQQKECQ; -.
DR PhylomeDB; Q7Z2W9; -.
DR TreeFam; TF324867; -.
DR PathwayCommons; Q7Z2W9; -.
DR Reactome; R-HSA-5368286; Mitochondrial translation initiation.
DR Reactome; R-HSA-5389840; Mitochondrial translation elongation.
DR Reactome; R-HSA-5419276; Mitochondrial translation termination.
DR SignaLink; Q7Z2W9; -.
DR SIGNOR; Q7Z2W9; -.
DR BioGRID-ORCS; 219927; 520 hits in 1088 CRISPR screens.
DR ChiTaRS; MRPL21; human.
DR GenomeRNAi; 219927; -.
DR Pharos; Q7Z2W9; Tdark.
DR PRO; PR:Q7Z2W9; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q7Z2W9; protein.
DR Bgee; ENSG00000197345; Expressed in left ventricle myocardium and 174 other tissues.
DR ExpressionAtlas; Q7Z2W9; baseline and differential.
DR Genevisible; Q7Z2W9; HS.
DR GO; GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
DR GO; GO:0005762; C:mitochondrial large ribosomal subunit; IDA:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IDA:UniProtKB.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0032543; P:mitochondrial translation; IC:ComplexPortal.
DR InterPro; IPR036164; L21-like_sf.
DR InterPro; IPR028909; L21p-like.
DR InterPro; IPR001787; Ribosomal_L21.
DR PANTHER; PTHR21349; PTHR21349; 1.
DR Pfam; PF00829; Ribosomal_L21p; 1.
DR SUPFAM; SSF141091; SSF141091; 1.
DR TIGRFAMs; TIGR00061; L21; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Mitochondrion; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein; Transit peptide.
FT TRANSIT 1..39
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 40..205
FT /note="39S ribosomal protein L21, mitochondrial"
FT /id="PRO_0000252442"
FT VAR_SEQ 1..85
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_045633"
FT TURN 55..57
FT /evidence="ECO:0007829|PDB:7OF0"
FT HELIX 69..89
FT /evidence="ECO:0007829|PDB:7OF0"
FT STRAND 96..101
FT /evidence="ECO:0007829|PDB:7OF0"
FT STRAND 104..109
FT /evidence="ECO:0007829|PDB:7OF0"
FT STRAND 113..118
FT /evidence="ECO:0007829|PDB:7OF0"
FT STRAND 127..130
FT /evidence="ECO:0007829|PDB:7OF0"
FT STRAND 133..137
FT /evidence="ECO:0007829|PDB:7OF0"
FT STRAND 139..147
FT /evidence="ECO:0007829|PDB:7OF0"
FT TURN 151..153
FT /evidence="ECO:0007829|PDB:7OF0"
FT STRAND 154..165
FT /evidence="ECO:0007829|PDB:7OF0"
FT STRAND 169..175
FT /evidence="ECO:0007829|PDB:7OF0"
FT TURN 176..179
FT /evidence="ECO:0007829|PDB:7OF0"
FT STRAND 180..186
FT /evidence="ECO:0007829|PDB:7OF0"
FT STRAND 189..200
FT /evidence="ECO:0007829|PDB:7OF0"
SQ SEQUENCE 205 AA; 22815 MW; B4AF172AB0C1E5FB CRC64;
MAASSLTVTL GRLASACSHS ILRPSGPGAA SLWSASRRFN SQSTSYLPGY VPKTSLSSPP
WPEVVLPDPV EETRHHAEVV KKVNEMIVTG QYGRLFAVVH FASRQWKVTS EDLILIGNEL
DLACGERIRL EKVLLVGADN FTLLGKPLLG KDLVRVEATV IEKTESWPRI IMRFRKRKNF
KKKRIVTTPQ TVLRINSIEI APCLL
