RM21_MOUSE
ID RM21_MOUSE Reviewed; 209 AA.
AC Q9D1N9; Q9CSH9; Q9D214;
DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=39S ribosomal protein L21, mitochondrial;
DE Short=L21mt;
DE Short=MRP-L21;
DE Flags: Precursor;
GN Name=Mrpl21; Synonyms=D9Wsu149;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Embryo, and Spinal cord;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Spleen, and
RC Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Component of the mitochondrial ribosome large subunit (39S)
CC which comprises a 16S rRNA and about 50 distinct proteins.
CC {ECO:0000250|UniProtKB:Q7Z2W9}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q7Z2W9}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9D1N9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9D1N9-2; Sequence=VSP_020975;
CC -!- SIMILARITY: Belongs to the bacterial ribosomal protein bL21 family.
CC {ECO:0000305}.
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DR EMBL; AK003285; BAB22690.1; -; mRNA.
DR EMBL; AK012784; BAB28467.1; -; mRNA.
DR EMBL; AK020739; BAB32196.1; -; mRNA.
DR EMBL; BC028768; AAH28768.1; -; mRNA.
DR CCDS; CCDS29394.1; -. [Q9D1N9-2]
DR CCDS; CCDS84406.1; -. [Q9D1N9-1]
DR RefSeq; NP_001334349.1; NM_001347420.1. [Q9D1N9-1]
DR RefSeq; NP_758456.2; NM_172252.3. [Q9D1N9-2]
DR AlphaFoldDB; Q9D1N9; -.
DR SMR; Q9D1N9; -.
DR BioGRID; 237278; 1.
DR ComplexPortal; CPX-5302; 39S mitochondrial large ribosomal subunit.
DR STRING; 10090.ENSMUSP00000025745; -.
DR PhosphoSitePlus; Q9D1N9; -.
DR SwissPalm; Q9D1N9; -.
DR EPD; Q9D1N9; -.
DR MaxQB; Q9D1N9; -.
DR PaxDb; Q9D1N9; -.
DR PeptideAtlas; Q9D1N9; -.
DR PRIDE; Q9D1N9; -.
DR ProteomicsDB; 300520; -. [Q9D1N9-1]
DR ProteomicsDB; 300521; -. [Q9D1N9-2]
DR Antibodypedia; 30611; 147 antibodies from 22 providers.
DR DNASU; 353242; -.
DR Ensembl; ENSMUST00000025743; ENSMUSP00000025743; ENSMUSG00000024829. [Q9D1N9-1]
DR Ensembl; ENSMUST00000025745; ENSMUSP00000025745; ENSMUSG00000024829. [Q9D1N9-2]
DR GeneID; 353242; -.
DR KEGG; mmu:353242; -.
DR UCSC; uc008fwd.1; mouse. [Q9D1N9-1]
DR UCSC; uc008fwe.1; mouse. [Q9D1N9-2]
DR CTD; 219927; -.
DR MGI; MGI:2660674; Mrpl21.
DR VEuPathDB; HostDB:ENSMUSG00000024829; -.
DR eggNOG; KOG1686; Eukaryota.
DR GeneTree; ENSGT00390000005535; -.
DR HOGENOM; CLU_061463_5_0_1; -.
DR InParanoid; Q9D1N9; -.
DR OMA; DQQKECQ; -.
DR OrthoDB; 1586807at2759; -.
DR TreeFam; TF324867; -.
DR Reactome; R-MMU-5389840; Mitochondrial translation elongation.
DR Reactome; R-MMU-5419276; Mitochondrial translation termination.
DR BioGRID-ORCS; 353242; 21 hits in 59 CRISPR screens.
DR ChiTaRS; Mrpl21; mouse.
DR PRO; PR:Q9D1N9; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q9D1N9; protein.
DR Bgee; ENSMUSG00000024829; Expressed in ectoplacental cone and 154 other tissues.
DR ExpressionAtlas; Q9D1N9; baseline and differential.
DR Genevisible; Q9D1N9; MM.
DR GO; GO:0005743; C:mitochondrial inner membrane; IC:ComplexPortal.
DR GO; GO:0005762; C:mitochondrial large ribosomal subunit; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0032543; P:mitochondrial translation; IC:ComplexPortal.
DR InterPro; IPR036164; L21-like_sf.
DR InterPro; IPR028909; L21p-like.
DR InterPro; IPR001787; Ribosomal_L21.
DR PANTHER; PTHR21349; PTHR21349; 1.
DR Pfam; PF00829; Ribosomal_L21p; 1.
DR SUPFAM; SSF141091; SSF141091; 1.
DR TIGRFAMs; TIGR00061; L21; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Mitochondrion; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein; Transit peptide.
FT TRANSIT 1..43
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 44..209
FT /note="39S ribosomal protein L21, mitochondrial"
FT /id="PRO_0000252443"
FT VAR_SEQ 189..209
FT /note="IIVNPQTILRINTIEIAPRLL -> NTDPSGYLCLSACQREQFSEVGPTLHL
FT V (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_020975"
SQ SEQUENCE 209 AA; 23366 MW; 276CEE55525B9CF5 CRC64;
MAAAIAASAL PGAFGRLVSV CSRSILASQG SGSASLWSAS RRFNSQSASY PQGYVPKTSL
SSPPWQEVVL PDPVEETRHH AEVVKRVNEL IATGQYGRLF AVVHFASHQW KVTAEDLILI
ENELDIKCGE RIRLEKVLLV GADNFTLLGK PLLRKELVRV EATVIEKTES WPKINMKFRK
RKNFRKKKII VNPQTILRIN TIEIAPRLL
