RM22_HUMAN
ID RM22_HUMAN Reviewed; 206 AA.
AC Q9NWU5; A6NGJ8; Q5H9Q1; Q96Q51; Q9P006;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=39S ribosomal protein L22, mitochondrial;
DE Short=L22mt;
DE Short=MRP-L22;
DE AltName: Full=39S ribosomal protein L25, mitochondrial;
DE Short=L25mt;
DE Short=MRP-L25;
DE AltName: Full=Mitochondrial large ribosomal subunit protein uL22m {ECO:0000303|PubMed:25278503};
DE Flags: Precursor;
GN Name=MRPL22; Synonyms=MRPL25, RPML25; ORFNames=HSPC158;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Umbilical cord blood;
RX PubMed=11042152; DOI=10.1101/gr.140200;
RA Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G.,
RA Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W.,
RA Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.;
RT "Cloning and functional analysis of cDNAs with open reading frames for 300
RT previously undefined genes expressed in CD34+ hematopoietic stem/progenitor
RT cells.";
RL Genome Res. 10:1546-1560(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Carcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Retina;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 170-206.
RX PubMed=11543634; DOI=10.1006/geno.2001.6622;
RA Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S.,
RA Watanabe K., Tanaka T.;
RT "The human mitochondrial ribosomal protein genes: mapping of 54 genes to
RT the chromosomes and implications for human disorders.";
RL Genomics 77:65-70(2001).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
RN [9] {ECO:0007744|PDB:3J7Y}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.40 ANGSTROMS), SUBCELLULAR LOCATION,
RP AND SUBUNIT.
RX PubMed=25278503; DOI=10.1126/science.1258026;
RA Brown A., Amunts A., Bai X.C., Sugimoto Y., Edwards P.C., Murshudov G.,
RA Scheres S.H., Ramakrishnan V.;
RT "Structure of the large ribosomal subunit from human mitochondria.";
RL Science 346:718-722(2014).
RN [10] {ECO:0007744|PDB:5OOL, ECO:0007744|PDB:5OOM}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.03 ANGSTROMS), SUBCELLULAR LOCATION,
RP AND SUBUNIT.
RX PubMed=28892042; DOI=10.1038/nsmb.3464;
RA Brown A., Rathore S., Kimanius D., Aibara S., Bai X.C., Rorbach J.,
RA Amunts A., Ramakrishnan V.;
RT "Structures of the human mitochondrial ribosome in native states of
RT assembly.";
RL Nat. Struct. Mol. Biol. 24:866-869(2017).
CC -!- SUBUNIT: Component of the mitochondrial large ribosomal subunit (mt-
CC LSU) (PubMed:28892042, PubMed:25278503). Mature mammalian 55S
CC mitochondrial ribosomes consist of a small (28S) and a large (39S)
CC subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-
CC rRNA) and 30 different proteins. The 39S large subunit contains a 16S
CC rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-
CC tRNA(Val)), which plays an integral structural role, and 52 different
CC proteins. {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:28892042}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503,
CC ECO:0000269|PubMed:28892042}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9NWU5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NWU5-2; Sequence=VSP_021745;
CC Name=3;
CC IsoId=Q9NWU5-3; Sequence=VSP_044501;
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL22 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF29122.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF161507; AAF29122.1; ALT_FRAME; mRNA.
DR EMBL; AK000601; BAA91282.1; -; mRNA.
DR EMBL; AK302784; BAG63988.1; -; mRNA.
DR EMBL; CR933679; CAI45973.1; -; mRNA.
DR EMBL; AC008410; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC008421; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC012565; AAH12565.1; -; mRNA.
DR EMBL; AB051622; BAB54950.1; -; Genomic_DNA.
DR CCDS; CCDS4331.1; -. [Q9NWU5-1]
DR CCDS; CCDS43391.1; -. [Q9NWU5-3]
DR RefSeq; NP_001014990.1; NM_001014990.2. [Q9NWU5-3]
DR RefSeq; NP_054899.2; NM_014180.3. [Q9NWU5-1]
DR PDB; 3J7Y; EM; 3.40 A; T=1-206.
DR PDB; 5OOL; EM; 3.06 A; T=1-206.
DR PDB; 5OOM; EM; 3.03 A; T=1-206.
DR PDB; 6NU2; EM; 3.90 A; T=41-206.
DR PDB; 6NU3; EM; 4.40 A; T=1-206.
DR PDB; 6ZM5; EM; 2.89 A; T=1-206.
DR PDB; 6ZM6; EM; 2.59 A; T=1-206.
DR PDB; 6ZSA; EM; 4.00 A; XT=1-206.
DR PDB; 6ZSB; EM; 4.50 A; XT=1-206.
DR PDB; 6ZSC; EM; 3.50 A; XT=1-206.
DR PDB; 6ZSD; EM; 3.70 A; XT=1-206.
DR PDB; 6ZSE; EM; 5.00 A; XT=1-206.
DR PDB; 6ZSG; EM; 4.00 A; XT=1-206.
DR PDB; 7A5F; EM; 4.40 A; T3=1-206.
DR PDB; 7A5G; EM; 4.33 A; T3=1-206.
DR PDB; 7ODR; EM; 2.90 A; T=1-206.
DR PDB; 7ODS; EM; 3.10 A; T=1-206.
DR PDB; 7ODT; EM; 3.10 A; T=1-206.
DR PDB; 7OF0; EM; 2.20 A; T=1-206.
DR PDB; 7OF2; EM; 2.70 A; T=1-206.
DR PDB; 7OF3; EM; 2.70 A; T=1-206.
DR PDB; 7OF4; EM; 2.70 A; T=1-206.
DR PDB; 7OF5; EM; 2.90 A; T=1-206.
DR PDB; 7OF6; EM; 2.60 A; T=1-206.
DR PDB; 7OF7; EM; 2.50 A; T=1-206.
DR PDB; 7OG4; EM; 3.80 A; XT=1-206.
DR PDB; 7OI6; EM; 5.70 A; T=1-206.
DR PDB; 7OI7; EM; 3.50 A; T=1-206.
DR PDB; 7OI8; EM; 3.50 A; T=1-206.
DR PDB; 7OI9; EM; 3.30 A; T=1-206.
DR PDB; 7OIA; EM; 3.20 A; T=1-206.
DR PDB; 7OIB; EM; 3.30 A; T=1-206.
DR PDB; 7OIC; EM; 3.10 A; T=1-206.
DR PDB; 7OID; EM; 3.70 A; T=1-206.
DR PDB; 7OIE; EM; 3.50 A; T=1-206.
DR PDB; 7PD3; EM; 3.40 A; T=1-206.
DR PDB; 7QH6; EM; 3.08 A; T=1-206.
DR PDBsum; 3J7Y; -.
DR PDBsum; 5OOL; -.
DR PDBsum; 5OOM; -.
DR PDBsum; 6NU2; -.
DR PDBsum; 6NU3; -.
DR PDBsum; 6ZM5; -.
DR PDBsum; 6ZM6; -.
DR PDBsum; 6ZSA; -.
DR PDBsum; 6ZSB; -.
DR PDBsum; 6ZSC; -.
DR PDBsum; 6ZSD; -.
DR PDBsum; 6ZSE; -.
DR PDBsum; 6ZSG; -.
DR PDBsum; 7A5F; -.
DR PDBsum; 7A5G; -.
DR PDBsum; 7ODR; -.
DR PDBsum; 7ODS; -.
DR PDBsum; 7ODT; -.
DR PDBsum; 7OF0; -.
DR PDBsum; 7OF2; -.
DR PDBsum; 7OF3; -.
DR PDBsum; 7OF4; -.
DR PDBsum; 7OF5; -.
DR PDBsum; 7OF6; -.
DR PDBsum; 7OF7; -.
DR PDBsum; 7OG4; -.
DR PDBsum; 7OI6; -.
DR PDBsum; 7OI7; -.
DR PDBsum; 7OI8; -.
DR PDBsum; 7OI9; -.
DR PDBsum; 7OIA; -.
DR PDBsum; 7OIB; -.
DR PDBsum; 7OIC; -.
DR PDBsum; 7OID; -.
DR PDBsum; 7OIE; -.
DR PDBsum; 7PD3; -.
DR PDBsum; 7QH6; -.
DR AlphaFoldDB; Q9NWU5; -.
DR SMR; Q9NWU5; -.
DR BioGRID; 118862; 215.
DR ComplexPortal; CPX-5226; 39S mitochondrial large ribosomal subunit.
DR CORUM; Q9NWU5; -.
DR IntAct; Q9NWU5; 41.
DR MINT; Q9NWU5; -.
DR STRING; 9606.ENSP00000431040; -.
DR GlyGen; Q9NWU5; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9NWU5; -.
DR MetOSite; Q9NWU5; -.
DR PhosphoSitePlus; Q9NWU5; -.
DR SwissPalm; Q9NWU5; -.
DR BioMuta; MRPL22; -.
DR DMDM; 74753031; -.
DR EPD; Q9NWU5; -.
DR jPOST; Q9NWU5; -.
DR MassIVE; Q9NWU5; -.
DR MaxQB; Q9NWU5; -.
DR PaxDb; Q9NWU5; -.
DR PeptideAtlas; Q9NWU5; -.
DR PRIDE; Q9NWU5; -.
DR ProteomicsDB; 1134; -.
DR ProteomicsDB; 82983; -. [Q9NWU5-1]
DR ProteomicsDB; 82984; -. [Q9NWU5-2]
DR TopDownProteomics; Q9NWU5-1; -. [Q9NWU5-1]
DR Antibodypedia; 28351; 117 antibodies from 18 providers.
DR DNASU; 29093; -.
DR Ensembl; ENST00000265229.12; ENSP00000265229.8; ENSG00000082515.18. [Q9NWU5-3]
DR Ensembl; ENST00000523037.6; ENSP00000431040.1; ENSG00000082515.18. [Q9NWU5-1]
DR GeneID; 29093; -.
DR KEGG; hsa:29093; -.
DR MANE-Select; ENST00000523037.6; ENSP00000431040.1; NM_014180.4; NP_054899.2.
DR UCSC; uc003lvy.5; human. [Q9NWU5-1]
DR CTD; 29093; -.
DR GeneCards; MRPL22; -.
DR HGNC; HGNC:14480; MRPL22.
DR HPA; ENSG00000082515; Low tissue specificity.
DR MIM; 611835; gene.
DR neXtProt; NX_Q9NWU5; -.
DR OpenTargets; ENSG00000082515; -.
DR PharmGKB; PA30952; -.
DR VEuPathDB; HostDB:ENSG00000082515; -.
DR eggNOG; KOG1711; Eukaryota.
DR GeneTree; ENSGT00390000002110; -.
DR HOGENOM; CLU_100005_1_0_1; -.
DR InParanoid; Q9NWU5; -.
DR OrthoDB; 1054896at2759; -.
DR PhylomeDB; Q9NWU5; -.
DR TreeFam; TF315111; -.
DR PathwayCommons; Q9NWU5; -.
DR Reactome; R-HSA-5368286; Mitochondrial translation initiation.
DR Reactome; R-HSA-5389840; Mitochondrial translation elongation.
DR Reactome; R-HSA-5419276; Mitochondrial translation termination.
DR SignaLink; Q9NWU5; -.
DR SIGNOR; Q9NWU5; -.
DR BioGRID-ORCS; 29093; 224 hits in 1092 CRISPR screens.
DR ChiTaRS; MRPL22; human.
DR GeneWiki; MRPL22; -.
DR GenomeRNAi; 29093; -.
DR Pharos; Q9NWU5; Tdark.
DR PRO; PR:Q9NWU5; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q9NWU5; protein.
DR Bgee; ENSG00000082515; Expressed in mucosa of transverse colon and 198 other tissues.
DR ExpressionAtlas; Q9NWU5; baseline and differential.
DR Genevisible; Q9NWU5; HS.
DR GO; GO:0015934; C:large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
DR GO; GO:0005762; C:mitochondrial large ribosomal subunit; IDA:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IDA:UniProtKB.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0032543; P:mitochondrial translation; IC:ComplexPortal.
DR GO; GO:0042255; P:ribosome assembly; IBA:GO_Central.
DR CDD; cd00336; Ribosomal_L22; 1.
DR Gene3D; 3.90.470.10; -; 1.
DR InterPro; IPR001063; Ribosomal_L22.
DR InterPro; IPR036394; Ribosomal_L22/L17_sf.
DR InterPro; IPR005727; Ribosomal_L22_bac/chlpt-type.
DR PANTHER; PTHR13501; PTHR13501; 1.
DR Pfam; PF00237; Ribosomal_L22; 1.
DR SUPFAM; SSF54843; SSF54843; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Mitochondrion; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein; Transit peptide.
FT TRANSIT 1..40
FT /note="Mitochondrion"
FT /evidence="ECO:0000250"
FT CHAIN 41..206
FT /note="39S ribosomal protein L22, mitochondrial"
FT /id="PRO_0000261644"
FT VAR_SEQ 1..80
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_044501"
FT VAR_SEQ 2..87
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_021745"
FT VARIANT 154
FT /note="G -> S (in dbSNP:rs3749671)"
FT /id="VAR_029471"
FT HELIX 44..47
FT /evidence="ECO:0007829|PDB:7OF0"
FT HELIX 48..50
FT /evidence="ECO:0007829|PDB:7OF0"
FT STRAND 58..60
FT /evidence="ECO:0007829|PDB:5OOM"
FT STRAND 66..76
FT /evidence="ECO:0007829|PDB:7OF0"
FT HELIX 78..88
FT /evidence="ECO:0007829|PDB:7OF0"
FT STRAND 89..92
FT /evidence="ECO:0007829|PDB:5OOL"
FT HELIX 93..101
FT /evidence="ECO:0007829|PDB:7OF0"
FT HELIX 106..125
FT /evidence="ECO:0007829|PDB:7OF0"
FT STRAND 131..143
FT /evidence="ECO:0007829|PDB:7OF0"
FT STRAND 147..152
FT /evidence="ECO:0007829|PDB:7OF0"
FT STRAND 154..156
FT /evidence="ECO:0007829|PDB:5OOL"
FT STRAND 158..163
FT /evidence="ECO:0007829|PDB:7OF0"
FT STRAND 166..176
FT /evidence="ECO:0007829|PDB:7OF0"
FT HELIX 186..198
FT /evidence="ECO:0007829|PDB:7OF0"
SQ SEQUENCE 206 AA; 23641 MW; EDF999932609F05D CRC64;
MAAAVLGQLG ALWIHNLRSR GKLALGVLPQ SYIHTSASLD ISRKWEKKNK IVYPPQLPGE
PRRPAEIYHC RRQIKYSKDK MWYLAKLIRG MSIDQALAQL EFNDKKGAKI IKEVLLEAQD
MAVRDHNVEF RSNLYIAEST SGRGQCLKRI RYHGRGRFGI MEKVYCHYFV KLVEGPPPPP
EPPKTAVAHA KEYIQQLRSR TIVHTL
