ID   RM22_MOUSE              Reviewed;         206 AA.
AC   Q8BU88; Q8BK04;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=39S ribosomal protein L22, mitochondrial;
DE            Short=L22mt;
DE            Short=MRP-L22;
DE   Flags: Precursor;
GN   Name=Mrpl22;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Embryo, Eye, and Lung;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Spleen, and
RC   Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SUBUNIT: Component of the mitochondrial ribosome large subunit (39S)
CC       which comprises a 16S rRNA and about 50 distinct proteins.
CC       {ECO:0000250|UniProtKB:Q9NWU5}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q9NWU5}.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uL22 family.
CC       {ECO:0000305}.
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DR   EMBL; AK077615; BAC36901.1; -; mRNA.
DR   EMBL; AK086913; BAC39761.1; -; mRNA.
DR   EMBL; AK164417; BAE37779.1; -; mRNA.
DR   EMBL; AL928857; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC061191; AAH61191.1; -; mRNA.
DR   CCDS; CCDS24724.1; -.
DR   RefSeq; NP_778166.2; NM_175001.3.
DR   AlphaFoldDB; Q8BU88; -.
DR   SMR; Q8BU88; -.
DR   BioGRID; 229782; 2.
DR   ComplexPortal; CPX-5302; 39S mitochondrial large ribosomal subunit.
DR   IntAct; Q8BU88; 1.
DR   STRING; 10090.ENSMUSP00000020820; -.
DR   iPTMnet; Q8BU88; -.
DR   PhosphoSitePlus; Q8BU88; -.
DR   EPD; Q8BU88; -.
DR   MaxQB; Q8BU88; -.
DR   PaxDb; Q8BU88; -.
DR   PeptideAtlas; Q8BU88; -.
DR   PRIDE; Q8BU88; -.
DR   ProteomicsDB; 299859; -.
DR   Antibodypedia; 28351; 117 antibodies from 18 providers.
DR   DNASU; 216767; -.
DR   Ensembl; ENSMUST00000020820; ENSMUSP00000020820; ENSMUSG00000020514.
DR   GeneID; 216767; -.
DR   KEGG; mmu:216767; -.
DR   UCSC; uc007jap.3; mouse.
DR   CTD; 29093; -.
DR   MGI; MGI:1333794; Mrpl22.
DR   VEuPathDB; HostDB:ENSMUSG00000020514; -.
DR   eggNOG; KOG1711; Eukaryota.
DR   GeneTree; ENSGT00390000002110; -.
DR   HOGENOM; CLU_100005_1_0_1; -.
DR   InParanoid; Q8BU88; -.
DR   OMA; HKVIRQM; -.
DR   OrthoDB; 1054896at2759; -.
DR   PhylomeDB; Q8BU88; -.
DR   TreeFam; TF315111; -.
DR   Reactome; R-MMU-5389840; Mitochondrial translation elongation.
DR   Reactome; R-MMU-5419276; Mitochondrial translation termination.
DR   BioGRID-ORCS; 216767; 25 hits in 76 CRISPR screens.
DR   ChiTaRS; Mrpl22; mouse.
DR   PRO; PR:Q8BU88; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; Q8BU88; protein.
DR   Bgee; ENSMUSG00000020514; Expressed in morula and 62 other tissues.
DR   Genevisible; Q8BU88; MM.
DR   GO; GO:0015934; C:large ribosomal subunit; IBA:GO_Central.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IC:ComplexPortal.
DR   GO; GO:0005762; C:mitochondrial large ribosomal subunit; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR   GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR   GO; GO:0032543; P:mitochondrial translation; IC:ComplexPortal.
DR   GO; GO:0042255; P:ribosome assembly; IBA:GO_Central.
DR   CDD; cd00336; Ribosomal_L22; 1.
DR   Gene3D; 3.90.470.10; -; 1.
DR   InterPro; IPR001063; Ribosomal_L22.
DR   InterPro; IPR036394; Ribosomal_L22/L17_sf.
DR   InterPro; IPR005727; Ribosomal_L22_bac/chlpt-type.
DR   PANTHER; PTHR13501; PTHR13501; 1.
DR   Pfam; PF00237; Ribosomal_L22; 1.
DR   SUPFAM; SSF54843; SSF54843; 1.
PE   1: Evidence at protein level;
KW   Mitochondrion; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW   Transit peptide.
FT   TRANSIT         1..40
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000250"
FT   CHAIN           41..206
FT                   /note="39S ribosomal protein L22, mitochondrial"
FT                   /id="PRO_0000261645"
FT   CONFLICT        198
FT                   /note="R -> P (in Ref. 1; BAC36901)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   206 AA;  23805 MW;  B7326DC02BED3390 CRC64;
     MAAALLRELG ALRVPNLRIW ATQTLRVLPP SCIHTSASLD ISRKWEKKNK IVYPPQLPGE
     PRRPAEIYHC RRQIKYSKDK MWYLAKMIRG MSIDQALAQL EFNDKKGAQI IKEVLLEAQD
     MAVRDHNVEF RSNLHIAEST SGRGQCLKRI RYHGRGRFGI MEKVYCHYFV KLVEGPPPPP
     EVPKTAVDHA KDYIQQLRSR TIIHTL