RM24_MOUSE
ID RM24_MOUSE Reviewed; 216 AA.
AC Q9CQ06; Q9CX51; Q9D1L7; Q9D7R6;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=39S ribosomal protein L24, mitochondrial;
DE Short=L24mt;
DE Short=MRP-L24;
DE Flags: Precursor;
GN Name=Mrpl24;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RC TISSUE=Placenta, Small intestine, Stomach, and Wolffian duct;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II, and FVB/N; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Heart, Kidney, Liver, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Component of the mitochondrial ribosome large subunit (39S)
CC which comprises a 16S rRNA and about 50 distinct proteins.
CC {ECO:0000250|UniProtKB:Q96A35}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q96A35}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL24 family.
CC {ECO:0000305}.
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DR EMBL; AK003362; BAB22737.1; -; mRNA.
DR EMBL; AK008117; BAB25472.1; -; mRNA.
DR EMBL; AK008961; BAB25991.1; -; mRNA.
DR EMBL; AK013394; BAB28828.1; -; mRNA.
DR EMBL; AK019976; BAB31945.1; -; mRNA.
DR EMBL; AK020157; BAB32014.1; -; mRNA.
DR EMBL; AK167623; BAE39675.1; -; mRNA.
DR EMBL; BC004736; AAH04736.1; -; mRNA.
DR EMBL; BC025506; AAH25506.1; -; mRNA.
DR EMBL; BC031730; AAH31730.1; -; mRNA.
DR CCDS; CCDS38477.1; -.
DR RefSeq; NP_080867.2; NM_026591.3.
DR RefSeq; XP_006502003.1; XM_006501940.2.
DR RefSeq; XP_006502004.1; XM_006501941.3.
DR RefSeq; XP_006502005.1; XM_006501942.3.
DR AlphaFoldDB; Q9CQ06; -.
DR SMR; Q9CQ06; -.
DR ComplexPortal; CPX-5302; 39S mitochondrial large ribosomal subunit.
DR STRING; 10090.ENSMUSP00000113959; -.
DR iPTMnet; Q9CQ06; -.
DR PhosphoSitePlus; Q9CQ06; -.
DR EPD; Q9CQ06; -.
DR MaxQB; Q9CQ06; -.
DR PaxDb; Q9CQ06; -.
DR PeptideAtlas; Q9CQ06; -.
DR PRIDE; Q9CQ06; -.
DR ProteomicsDB; 299909; -.
DR Antibodypedia; 34225; 199 antibodies from 27 providers.
DR DNASU; 67707; -.
DR Ensembl; ENSMUST00000019854; ENSMUSP00000019854; ENSMUSG00000019710.
DR Ensembl; ENSMUST00000119968; ENSMUSP00000114111; ENSMUSG00000019710.
DR Ensembl; ENSMUST00000121048; ENSMUSP00000113959; ENSMUSG00000019710.
DR Ensembl; ENSMUST00000121920; ENSMUSP00000112885; ENSMUSG00000019710.
DR GeneID; 67707; -.
DR KEGG; mmu:67707; -.
DR UCSC; uc008ptd.1; mouse.
DR CTD; 79590; -.
DR MGI; MGI:1914957; Mrpl24.
DR VEuPathDB; HostDB:ENSMUSG00000019710; -.
DR eggNOG; KOG1708; Eukaryota.
DR GeneTree; ENSGT00390000014542; -.
DR HOGENOM; CLU_093315_0_1_1; -.
DR InParanoid; Q9CQ06; -.
DR OMA; DFEWRFT; -.
DR OrthoDB; 1007373at2759; -.
DR PhylomeDB; Q9CQ06; -.
DR TreeFam; TF105984; -.
DR Reactome; R-MMU-5389840; Mitochondrial translation elongation.
DR Reactome; R-MMU-5419276; Mitochondrial translation termination.
DR BioGRID-ORCS; 67707; 19 hits in 75 CRISPR screens.
DR ChiTaRS; Mrpl24; mouse.
DR PRO; PR:Q9CQ06; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q9CQ06; protein.
DR Bgee; ENSMUSG00000019710; Expressed in endocardial cushion and 278 other tissues.
DR ExpressionAtlas; Q9CQ06; baseline and differential.
DR Genevisible; Q9CQ06; MM.
DR GO; GO:0005743; C:mitochondrial inner membrane; IC:ComplexPortal.
DR GO; GO:0005762; C:mitochondrial large ribosomal subunit; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0032543; P:mitochondrial translation; IC:ComplexPortal.
DR GO; GO:0006412; P:translation; IBA:GO_Central.
DR CDD; cd06089; KOW_RPL26; 1.
DR Gene3D; 2.30.30.30; -; 1.
DR HAMAP; MF_01326_B; Ribosomal_L24_B; 1.
DR InterPro; IPR005824; KOW.
DR InterPro; IPR041988; KOW_RPL26/RPL24.
DR InterPro; IPR014722; Rib_L2_dom2.
DR InterPro; IPR003256; Ribosomal_L24.
DR InterPro; IPR005825; Ribosomal_L24/26_CS.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR PANTHER; PTHR12903; PTHR12903; 1.
DR Pfam; PF00467; KOW; 1.
DR Pfam; PF17136; ribosomal_L24; 1.
DR SMART; SM00739; KOW; 1.
DR SUPFAM; SSF50104; SSF50104; 1.
DR TIGRFAMs; TIGR01079; rplX_bact; 1.
DR PROSITE; PS01108; RIBOSOMAL_L24; 1.
PE 1: Evidence at protein level;
KW Mitochondrion; Phosphoprotein; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein; Transit peptide.
FT TRANSIT 1..9
FT /note="Mitochondrion"
FT /evidence="ECO:0000250"
FT CHAIN 10..216
FT /note="39S ribosomal protein L24, mitochondrial"
FT /id="PRO_0000270489"
FT DOMAIN 56..89
FT /note="KOW"
FT MOD_RES 24
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96A35"
FT CONFLICT 7..9
FT /note="LAL -> FAS (in Ref. 1; BAB25991)"
FT /evidence="ECO:0000305"
FT CONFLICT 14..15
FT /note="TS -> IC (in Ref. 1; BAB25991)"
FT /evidence="ECO:0000305"
FT CONFLICT 26..27
FT /note="PG -> RS (in Ref. 1; BAB25991)"
FT /evidence="ECO:0000305"
FT CONFLICT 30
FT /note="A -> G (in Ref. 1; BAB25991)"
FT /evidence="ECO:0000305"
FT CONFLICT 34
FT /note="K -> Q (in Ref. 1; BAB25991)"
FT /evidence="ECO:0000305"
FT CONFLICT 42
FT /note="R -> L (in Ref. 1; BAB22737)"
FT /evidence="ECO:0000305"
FT CONFLICT 48
FT /note="P -> A (in Ref. 1; BAB25991)"
FT /evidence="ECO:0000305"
FT CONFLICT 116
FT /note="L -> F (in Ref. 1; BAB32014)"
FT /evidence="ECO:0000305"
FT CONFLICT 143
FT /note="R -> L (in Ref. 1; BAB22737)"
FT /evidence="ECO:0000305"
FT CONFLICT 177
FT /note="T -> I (in Ref. 1; BAB32014)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 216 AA; 24945 MW; DE869E7630AF599F CRC64;
MRLSALLALA SKATSSPFYR YGMSRPGSIA DKRKNPPWSR RRPVVVEPIS DEDWHLFCGD
MVEILEGKDA GKQGKVVQVV RQRNWVVLEG LNTHYRYIGR TKDHRGTMIA SEAPLLHHQV
KLVDPVDRKP TEIQWRFTEA GERVRVSTRS GRIIPKPEFP RADGIVPETW TDGPKDTSVE
DALERTYVPR LKTLEEDVME AMGIQETRRF KKVYWY
