RM27_MOUSE
ID RM27_MOUSE Reviewed; 148 AA.
AC Q99N92;
DT 05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=39S ribosomal protein L27, mitochondrial;
DE Short=L27mt;
DE Short=MRP-L27;
DE Flags: Precursor;
GN Name=Mrpl27;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND SUBCELLULAR LOCATION.
RX PubMed=11279069; DOI=10.1074/jbc.m100432200;
RA Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A.,
RA Watanabe K.;
RT "Structural compensation for the deficit of rRNA with proteins in the
RT mammalian mitochondrial ribosome. Systematic analysis of protein components
RT of the large ribosomal subunit from mammalian mitochondria.";
RL J. Biol. Chem. 276:21724-21736(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Spleen, and
RC Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Component of the mitochondrial ribosome large subunit (39S)
CC which comprises a 16S rRNA and about 50 distinct proteins.
CC {ECO:0000250|UniProtKB:Q9P0M9}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11279069}.
CC -!- SIMILARITY: Belongs to the bacterial ribosomal protein bL27 family.
CC {ECO:0000305}.
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DR EMBL; AB049648; BAB40853.1; -; mRNA.
DR EMBL; BC030074; AAH30074.1; -; mRNA.
DR CCDS; CCDS25263.1; -.
DR RefSeq; NP_444391.1; NM_053161.2.
DR AlphaFoldDB; Q99N92; -.
DR SMR; Q99N92; -.
DR BioGRID; 220436; 11.
DR ComplexPortal; CPX-5302; 39S mitochondrial large ribosomal subunit.
DR STRING; 10090.ENSMUSP00000025278; -.
DR iPTMnet; Q99N92; -.
DR PhosphoSitePlus; Q99N92; -.
DR EPD; Q99N92; -.
DR jPOST; Q99N92; -.
DR MaxQB; Q99N92; -.
DR PaxDb; Q99N92; -.
DR PeptideAtlas; Q99N92; -.
DR PRIDE; Q99N92; -.
DR ProteomicsDB; 300399; -.
DR Antibodypedia; 18064; 91 antibodies from 21 providers.
DR DNASU; 94064; -.
DR Ensembl; ENSMUST00000025278; ENSMUSP00000025278; ENSMUSG00000024414.
DR GeneID; 94064; -.
DR KEGG; mmu:94064; -.
DR UCSC; uc007kzg.1; mouse.
DR CTD; 51264; -.
DR MGI; MGI:2137224; Mrpl27.
DR VEuPathDB; HostDB:ENSMUSG00000024414; -.
DR eggNOG; KOG4600; Eukaryota.
DR GeneTree; ENSGT00390000014660; -.
DR HOGENOM; CLU_143748_0_0_1; -.
DR InParanoid; Q99N92; -.
DR OMA; DGHYVSH; -.
DR OrthoDB; 1177118at2759; -.
DR PhylomeDB; Q99N92; -.
DR TreeFam; TF323523; -.
DR Reactome; R-MMU-5389840; Mitochondrial translation elongation.
DR Reactome; R-MMU-5419276; Mitochondrial translation termination.
DR BioGRID-ORCS; 94064; 23 hits in 108 CRISPR screens.
DR ChiTaRS; Mrpl27; mouse.
DR PRO; PR:Q99N92; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q99N92; protein.
DR Bgee; ENSMUSG00000024414; Expressed in proximal tubule and 66 other tissues.
DR Genevisible; Q99N92; MM.
DR GO; GO:0005743; C:mitochondrial inner membrane; IC:ComplexPortal.
DR GO; GO:0005762; C:mitochondrial large ribosomal subunit; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0003735; F:structural constituent of ribosome; ISO:MGI.
DR GO; GO:0032543; P:mitochondrial translation; IC:ComplexPortal.
DR GO; GO:0006412; P:translation; ISO:MGI.
DR InterPro; IPR001684; Ribosomal_L27.
DR PANTHER; PTHR15893; PTHR15893; 1.
DR Pfam; PF01016; Ribosomal_L27; 1.
DR PRINTS; PR00063; RIBOSOMALL27.
PE 1: Evidence at protein level;
KW Mitochondrion; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW Transit peptide.
FT TRANSIT 1..30
FT /note="Mitochondrion"
FT /evidence="ECO:0000250|UniProtKB:Q32PC3"
FT CHAIN 31..148
FT /note="39S ribosomal protein L27, mitochondrial"
FT /id="PRO_0000181230"
FT REGION 28..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 148 AA; 15945 MW; 4EDC088D3B123B1C CRC64;
MAAAALTLRT RAAVTALLSP TAPTALAVRH ASKKTGGSSK NLGGKSRGKH YGIKKMEGHY
VHAGNILGTQ RQFRWHPGAH VGLGRNKCLY ALEEGIVRYT KDVYVPNPKN TEAVDLVTSL
PKGAVLYKTF VHVVPAKPEG TFKLVDML
