RM28_MOUSE
ID RM28_MOUSE Reviewed; 257 AA.
AC Q9D1B9; A6H5Y0; Q3TR04; Q497Y8; Q66JU7;
DT 19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 3.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=39S ribosomal protein L28, mitochondrial;
DE Short=L28mt;
DE Short=MRP-L28;
DE Flags: Precursor;
GN Name=Mrpl28;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Adipose tissue, Cerebellum, Embryo, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II, FVB/N, and NMRI;
RC TISSUE=Brain, Mammary gland {ECO:0000269|PubMed:15489334}, and Thyroid;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Spleen, and
RC Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Component of the mitochondrial ribosome large subunit (39S)
CC which comprises a 16S rRNA and about 50 distinct proteins. Interacts
CC with OXA1L. {ECO:0000250|UniProtKB:Q13084,
CC ECO:0000250|UniProtKB:Q2HJJ1}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q13084}.
CC -!- SIMILARITY: Belongs to the bacterial ribosomal protein bL28 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH02293.2; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAH05797.2; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAH80753.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAI00323.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAB22962.2; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC27521.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC32780.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK003727; BAB22962.2; ALT_INIT; mRNA.
DR EMBL; AK031701; BAC27521.1; ALT_INIT; mRNA.
DR EMBL; AK046544; BAC32780.1; ALT_INIT; mRNA.
DR EMBL; AK163190; BAE37227.1; -; mRNA.
DR EMBL; BC002293; AAH02293.2; ALT_INIT; mRNA.
DR EMBL; BC005797; AAH05797.2; ALT_INIT; mRNA.
DR EMBL; BC080753; AAH80753.1; ALT_INIT; mRNA.
DR EMBL; BC100322; AAI00323.1; ALT_INIT; mRNA.
DR EMBL; BC145680; AAI45681.1; -; mRNA.
DR EMBL; BC145682; AAI45683.1; -; mRNA.
DR CCDS; CCDS37509.1; -.
DR RefSeq; NP_077189.2; NM_024227.3.
DR AlphaFoldDB; Q9D1B9; -.
DR SMR; Q9D1B9; -.
DR BioGRID; 212951; 9.
DR ComplexPortal; CPX-5302; 39S mitochondrial large ribosomal subunit.
DR IntAct; Q9D1B9; 1.
DR MINT; Q9D1B9; -.
DR STRING; 10090.ENSMUSP00000025014; -.
DR iPTMnet; Q9D1B9; -.
DR PhosphoSitePlus; Q9D1B9; -.
DR SwissPalm; Q9D1B9; -.
DR EPD; Q9D1B9; -.
DR MaxQB; Q9D1B9; -.
DR PaxDb; Q9D1B9; -.
DR PeptideAtlas; Q9D1B9; -.
DR PRIDE; Q9D1B9; -.
DR ProteomicsDB; 300400; -.
DR Antibodypedia; 22648; 281 antibodies from 33 providers.
DR Ensembl; ENSMUST00000025014; ENSMUSP00000025014; ENSMUSG00000024181.
DR GeneID; 68611; -.
DR KEGG; mmu:68611; -.
DR UCSC; uc008bdl.2; mouse.
DR CTD; 10573; -.
DR MGI; MGI:1915861; Mrpl28.
DR VEuPathDB; HostDB:ENSMUSG00000024181; -.
DR eggNOG; KOG3279; Eukaryota.
DR GeneTree; ENSGT00390000017359; -.
DR HOGENOM; CLU_078055_0_0_1; -.
DR InParanoid; Q9D1B9; -.
DR OMA; LKNRACD; -.
DR OrthoDB; 1558223at2759; -.
DR PhylomeDB; Q9D1B9; -.
DR TreeFam; TF313040; -.
DR Reactome; R-MMU-5389840; Mitochondrial translation elongation.
DR Reactome; R-MMU-5419276; Mitochondrial translation termination.
DR BioGRID-ORCS; 68611; 18 hits in 74 CRISPR screens.
DR ChiTaRS; Mrpl28; mouse.
DR PRO; PR:Q9D1B9; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q9D1B9; protein.
DR Bgee; ENSMUSG00000024181; Expressed in cardiac muscle of left ventricle and 262 other tissues.
DR ExpressionAtlas; Q9D1B9; baseline and differential.
DR Genevisible; Q9D1B9; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005743; C:mitochondrial inner membrane; IC:ComplexPortal.
DR GO; GO:0005762; C:mitochondrial large ribosomal subunit; ISS:UniProtKB.
DR GO; GO:0005761; C:mitochondrial ribosome; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0032543; P:mitochondrial translation; IC:ComplexPortal.
DR Gene3D; 2.30.170.40; -; 1.
DR InterPro; IPR034704; L28p-like.
DR InterPro; IPR026569; Ribo_L28/L24.
DR InterPro; IPR037147; Ribo_L28/L24_sf.
DR PANTHER; PTHR13528; PTHR13528; 1.
DR Pfam; PF00830; Ribosomal_L28; 1.
DR SUPFAM; SSF143800; SSF143800; 1.
PE 1: Evidence at protein level;
KW Mitochondrion; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW Transit peptide.
FT TRANSIT 1..55
FT /note="Mitochondrion"
FT /evidence="ECO:0000250"
FT CHAIN 56..257
FT /note="39S ribosomal protein L28, mitochondrial"
FT /id="PRO_0000030507"
SQ SEQUENCE 257 AA; 30170 MW; C011BF7EF537996C CRC64;
MPLHRYPVHL WQKLRLRQGI CARLPAHFLR SLEEERTPTP VHYKPHGTKF KINPKNGQRE
RVEDVPIPVH YPPESQQGLW GGEGLILGYR YANNDKLSKR VKKVWKPQLF TRELYSEILD
KKFTVTVTMR TLDLIDEAYG FDFYILKTPK EDLGSKFGMD LKRGMLLRLA RQDPHLHPEN
PERRAAIYDK YRSFVIPEAE AEWVGLTLEE ALEKQRLLEE KDPVPLFKVY VEELVQRLQE
QVLSRPAVVQ KRAGDHA
