RM30_MOUSE
ID RM30_MOUSE Reviewed; 160 AA.
AC Q9D7N6; Q99KJ7;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=39S ribosomal protein L30, mitochondrial;
DE Short=L30mt;
DE Short=MRP-L30;
DE Flags: Precursor;
GN Name=Mrpl30;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Thymus, and Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, and Liver;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Component of the mitochondrial ribosome large subunit (39S)
CC which comprises a 16S rRNA and about 50 distinct proteins.
CC {ECO:0000250|UniProtKB:Q8TCC3}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q8TCC3}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL30 family.
CC {ECO:0000305}.
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DR EMBL; AK009074; BAB26057.1; -; mRNA.
DR EMBL; AK089015; BAC40703.1; -; mRNA.
DR EMBL; BC004614; AAH04614.1; -; mRNA.
DR CCDS; CCDS14896.1; -.
DR RefSeq; NP_081374.1; NM_027098.2.
DR RefSeq; XP_006495675.1; XM_006495612.2.
DR RefSeq; XP_011236719.1; XM_011238417.2.
DR AlphaFoldDB; Q9D7N6; -.
DR SMR; Q9D7N6; -.
DR BioGRID; 223527; 6.
DR ComplexPortal; CPX-5302; 39S mitochondrial large ribosomal subunit.
DR STRING; 10090.ENSMUSP00000027256; -.
DR iPTMnet; Q9D7N6; -.
DR PhosphoSitePlus; Q9D7N6; -.
DR EPD; Q9D7N6; -.
DR MaxQB; Q9D7N6; -.
DR PaxDb; Q9D7N6; -.
DR PeptideAtlas; Q9D7N6; -.
DR PRIDE; Q9D7N6; -.
DR ProteomicsDB; 300522; -.
DR DNASU; 107734; -.
DR Ensembl; ENSMUST00000027256; ENSMUSP00000027256; ENSMUSG00000026087.
DR Ensembl; ENSMUST00000193673; ENSMUSP00000141654; ENSMUSG00000026087.
DR Ensembl; ENSMUST00000195373; ENSMUSP00000141693; ENSMUSG00000026087.
DR GeneID; 107734; -.
DR KEGG; mmu:107734; -.
DR UCSC; uc007asj.1; mouse.
DR CTD; 51263; -.
DR MGI; MGI:1333820; Mrpl30.
DR VEuPathDB; HostDB:ENSMUSG00000026087; -.
DR eggNOG; KOG4799; Eukaryota.
DR GeneTree; ENSGT00390000016769; -.
DR InParanoid; Q9D7N6; -.
DR OMA; VESFICT; -.
DR OrthoDB; 1446797at2759; -.
DR PhylomeDB; Q9D7N6; -.
DR TreeFam; TF314611; -.
DR Reactome; R-MMU-5389840; Mitochondrial translation elongation.
DR Reactome; R-MMU-5419276; Mitochondrial translation termination.
DR BioGRID-ORCS; 107734; 21 hits in 71 CRISPR screens.
DR ChiTaRS; Mrpl30; mouse.
DR PRO; PR:Q9D7N6; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q9D7N6; protein.
DR Bgee; ENSMUSG00000026087; Expressed in digastric muscle group and 256 other tissues.
DR ExpressionAtlas; Q9D7N6; baseline and differential.
DR Genevisible; Q9D7N6; MM.
DR GO; GO:0005743; C:mitochondrial inner membrane; IC:ComplexPortal.
DR GO; GO:0005762; C:mitochondrial large ribosomal subunit; ISS:UniProtKB.
DR GO; GO:0005761; C:mitochondrial ribosome; ISS:MGI.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0032543; P:mitochondrial translation; IC:ComplexPortal.
DR CDD; cd01658; Ribosomal_L30; 1.
DR Gene3D; 3.30.1390.20; -; 1.
DR InterPro; IPR036919; L30_ferredoxin-like_sf.
DR InterPro; IPR005996; Ribosomal_L30_bac-type.
DR InterPro; IPR016082; Ribosomal_L30_ferredoxin-like.
DR PANTHER; PTHR15892; PTHR15892; 1.
DR Pfam; PF00327; Ribosomal_L30; 1.
DR SUPFAM; SSF55129; SSF55129; 1.
PE 1: Evidence at protein level;
KW Mitochondrion; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW Transit peptide.
FT TRANSIT 1..34
FT /note="Mitochondrion"
FT /evidence="ECO:0000250"
FT CHAIN 35..160
FT /note="39S ribosomal protein L30, mitochondrial"
FT /id="PRO_0000273241"
FT REGION 44..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..61
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 10
FT /note="P -> Q (in Ref. 2; AAH04614)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 160 AA; 18342 MW; 8AE7C3BF6168B46A CRC64;
MAGVLRSAFP RPPCRLQTVK KGAESLIGTE WIRHKFTKSR IPDKVFQPKP EDHEKYGGDP
QNPHKLHIVT RIRSTKRRPY WEKDTIKMLG LQKAHSPQIH KNIPSVNAKL KVVKHLIRIQ
PLKLPQGLPT EETMSSTCLK STGELVVQWH LKPVEQEAKS
