RM33_MOUSE
ID RM33_MOUSE Reviewed; 65 AA.
AC Q9CQP0; Q9D860;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=39S ribosomal protein L33, mitochondrial;
DE Short=L33mt;
DE Short=MRP-L33;
DE Flags: Precursor;
GN Name=Mrpl33;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11279069; DOI=10.1074/jbc.m100432200;
RA Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A.,
RA Watanabe K.;
RT "Structural compensation for the deficit of rRNA with proteins in the
RT mammalian mitochondrial ribosome. Systematic analysis of protein components
RT of the large ribosomal subunit from mammalian mitochondria.";
RL J. Biol. Chem. 276:21724-21736(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and DBA/2J; TISSUE=Kidney, and Small intestine;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain, Mammary gland, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Heart, and Kidney;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Component of the mitochondrial ribosome large subunit (39S)
CC which comprises a 16S rRNA and about 50 distinct proteins.
CC {ECO:0000250|UniProtKB:O75394}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:O75394}.
CC -!- SIMILARITY: Belongs to the bacterial ribosomal protein bL33 family.
CC {ECO:0000305}.
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DR EMBL; AB049651; BAB40856.1; -; mRNA.
DR EMBL; AK002421; BAB22088.1; -; mRNA.
DR EMBL; AK008431; BAB25665.1; -; mRNA.
DR EMBL; AK021173; BAB32314.1; -; mRNA.
DR EMBL; AK167883; BAE39896.1; -; mRNA.
DR EMBL; BC037363; AAH37363.1; -; mRNA.
DR EMBL; BC051471; AAH51471.1; -; mRNA.
DR EMBL; BC055724; AAH55724.1; -; mRNA.
DR EMBL; BC059722; AAH59722.1; -; mRNA.
DR CCDS; CCDS39056.1; -.
DR RefSeq; NP_080072.2; NM_025796.3.
DR AlphaFoldDB; Q9CQP0; -.
DR SMR; Q9CQP0; -.
DR BioGRID; 211759; 6.
DR ComplexPortal; CPX-5302; 39S mitochondrial large ribosomal subunit.
DR STRING; 10090.ENSMUSP00000031024; -.
DR PhosphoSitePlus; Q9CQP0; -.
DR EPD; Q9CQP0; -.
DR MaxQB; Q9CQP0; -.
DR PaxDb; Q9CQP0; -.
DR PRIDE; Q9CQP0; -.
DR ProteomicsDB; 299910; -.
DR TopDownProteomics; Q9CQP0; -.
DR Antibodypedia; 58354; 113 antibodies from 23 providers.
DR DNASU; 66845; -.
DR Ensembl; ENSMUST00000031024; ENSMUSP00000031024; ENSMUSG00000106918.
DR GeneID; 66845; -.
DR KEGG; mmu:66845; -.
DR UCSC; uc008wyt.2; mouse.
DR CTD; 9553; -.
DR MGI; MGI:2137225; Mrpl33.
DR VEuPathDB; HostDB:ENSMUSG00000106918; -.
DR eggNOG; KOG3505; Eukaryota.
DR GeneTree; ENSGT00390000010130; -.
DR HOGENOM; CLU_190949_1_2_1; -.
DR InParanoid; Q9CQP0; -.
DR OMA; KHDPLVN; -.
DR OrthoDB; 1634766at2759; -.
DR TreeFam; TF300279; -.
DR Reactome; R-MMU-5389840; Mitochondrial translation elongation.
DR Reactome; R-MMU-5419276; Mitochondrial translation termination.
DR BioGRID-ORCS; 66845; 19 hits in 70 CRISPR screens.
DR PRO; PR:Q9CQP0; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q9CQP0; protein.
DR Bgee; ENSMUSG00000106918; Expressed in granulocyte and 264 other tissues.
DR ExpressionAtlas; Q9CQP0; baseline and differential.
DR Genevisible; Q9CQP0; MM.
DR GO; GO:0005829; C:cytosol; IEA:UniProt.
DR GO; GO:0005743; C:mitochondrial inner membrane; IC:ComplexPortal.
DR GO; GO:0005762; C:mitochondrial large ribosomal subunit; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0032543; P:mitochondrial translation; IC:ComplexPortal.
DR Gene3D; 2.20.28.120; -; 1.
DR InterPro; IPR038584; L33_sf.
DR InterPro; IPR001705; Ribosomal_L33.
DR InterPro; IPR011332; Ribosomal_zn-bd.
DR Pfam; PF00471; Ribosomal_L33; 1.
DR SUPFAM; SSF57829; SSF57829; 1.
DR TIGRFAMs; TIGR01023; rpmG_bact; 1.
PE 1: Evidence at protein level;
KW Mitochondrion; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW Transit peptide.
FT TRANSIT 1..8
FT /note="Mitochondrion"
FT /evidence="ECO:0000250|UniProtKB:Q3SZ47"
FT CHAIN 9..65
FT /note="39S ribosomal protein L33, mitochondrial"
FT /id="PRO_0000238626"
FT CONFLICT 58
FT /note="E -> G (in Ref. 2; BAB25665)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 65 AA; 7416 MW; 6F8E69CA0359BE6F CRC64;
MLLSAVSFAK SKSKTILVKL VSQAGTGFSF NHKRSRLREK LSLLHYDPIV NKKVLFVEQK
KIRSL
