RM35_HUMAN
ID RM35_HUMAN Reviewed; 188 AA.
AC Q9NZE8; A6NKV6; B2RB93; Q658U7; Q8WWA2;
DT 02-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=39S ribosomal protein L35, mitochondrial;
DE Short=L35mt;
DE Short=MRP-L35;
DE AltName: Full=Mitochondrial large ribosomal subunit protein bL35m {ECO:0000303|PubMed:25278503};
DE Flags: Precursor;
GN Name=MRPL35; ORFNames=BM-007;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000312|EMBL:AAF64263.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Bone marrow;
RX PubMed=11042152; DOI=10.1101/gr.140200;
RA Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G.,
RA Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W.,
RA Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.;
RT "Cloning and functional analysis of cDNAs with open reading frames for 300
RT previously undefined genes expressed in CD34+ hematopoietic stem/progenitor
RT cells.";
RL Genome Res. 10:1546-1560(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Stomach;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANTS SER-19 AND
RP THR-24.
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION.
RX PubMed=11551941; DOI=10.1074/jbc.m106510200;
RA Koc E.C., Burkhart W., Blackburn K., Moyer M.B., Schlatzer D.M.,
RA Moseley A., Spremulli L.L.;
RT "The large subunit of the mammalian mitochondrial ribosome. Analysis of the
RT complement of ribosomal proteins present.";
RL J. Biol. Chem. 276:43958-43969(2001).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [8] {ECO:0007744|PDB:3J7Y}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.40 ANGSTROMS), SUBCELLULAR LOCATION,
RP AND SUBUNIT.
RX PubMed=25278503; DOI=10.1126/science.1258026;
RA Brown A., Amunts A., Bai X.C., Sugimoto Y., Edwards P.C., Murshudov G.,
RA Scheres S.H., Ramakrishnan V.;
RT "Structure of the large ribosomal subunit from human mitochondria.";
RL Science 346:718-722(2014).
RN [9] {ECO:0007744|PDB:3J9M}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.50 ANGSTROMS), SUBCELLULAR LOCATION,
RP AND SUBUNIT.
RX PubMed=25838379; DOI=10.1126/science.aaa1193;
RA Amunts A., Brown A., Toots J., Scheres S.H., Ramakrishnan V.;
RT "Ribosome. The structure of the human mitochondrial ribosome.";
RL Science 348:95-98(2015).
RN [10] {ECO:0007744|PDB:5OOL, ECO:0007744|PDB:5OOM}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.03 ANGSTROMS), SUBCELLULAR LOCATION,
RP AND SUBUNIT.
RX PubMed=28892042; DOI=10.1038/nsmb.3464;
RA Brown A., Rathore S., Kimanius D., Aibara S., Bai X.C., Rorbach J.,
RA Amunts A., Ramakrishnan V.;
RT "Structures of the human mitochondrial ribosome in native states of
RT assembly.";
RL Nat. Struct. Mol. Biol. 24:866-869(2017).
CC -!- SUBUNIT: Component of the mitochondrial large ribosomal subunit (mt-
CC LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). Mature
CC mammalian 55S mitochondrial ribosomes consist of a small (28S) and a
CC large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA
CC (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains
CC a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA
CC (mt-tRNA(Val)), which plays an integral structural role, and 52
CC different proteins. {ECO:0000269|PubMed:25278503,
CC ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
CC -!- INTERACTION:
CC Q9NZE8-2; Q6NTF9-3: RHBDD2; NbExp=3; IntAct=EBI-17590278, EBI-17589229;
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503,
CC ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9NZE8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NZE8-2; Sequence=VSP_036507;
CC -!- SIMILARITY: Belongs to the bacterial ribosomal protein bL35 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF64263.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF208849; AAF64263.1; ALT_FRAME; mRNA.
DR EMBL; AK314555; BAG37140.1; -; mRNA.
DR EMBL; AK314577; BAG37154.1; -; mRNA.
DR EMBL; AL832982; CAH56349.1; -; mRNA.
DR EMBL; AC009309; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC020651; AAH20651.1; -; mRNA.
DR CCDS; CCDS1987.1; -. [Q9NZE8-2]
DR CCDS; CCDS1988.1; -. [Q9NZE8-1]
DR RefSeq; NP_057706.2; NM_016622.3. [Q9NZE8-1]
DR RefSeq; NP_663619.1; NM_145644.2. [Q9NZE8-2]
DR PDB; 3J7Y; EM; 3.40 A; 3=1-188.
DR PDB; 3J9M; EM; 3.50 A; 3=1-188.
DR PDB; 5OOL; EM; 3.06 A; 3=1-188.
DR PDB; 5OOM; EM; 3.03 A; 3=1-188.
DR PDB; 6I9R; EM; 3.90 A; 3=1-188.
DR PDB; 6NU2; EM; 3.90 A; 3=94-188.
DR PDB; 6NU3; EM; 4.40 A; 3=1-188.
DR PDB; 6VLZ; EM; 2.97 A; 3=1-188.
DR PDB; 6VMI; EM; 2.96 A; 3=1-188.
DR PDB; 6ZM5; EM; 2.89 A; 3=1-188.
DR PDB; 6ZM6; EM; 2.59 A; 3=1-188.
DR PDB; 6ZS9; EM; 4.00 A; 3=1-188.
DR PDB; 6ZSA; EM; 4.00 A; 3=1-188.
DR PDB; 6ZSB; EM; 4.50 A; 3=1-188.
DR PDB; 6ZSC; EM; 3.50 A; 3=1-188.
DR PDB; 6ZSD; EM; 3.70 A; 3=1-188.
DR PDB; 6ZSE; EM; 5.00 A; 3=1-188.
DR PDB; 6ZSG; EM; 4.00 A; 3=1-188.
DR PDB; 7A5F; EM; 4.40 A; 33=1-188.
DR PDB; 7A5G; EM; 4.33 A; 33=1-188.
DR PDB; 7A5H; EM; 3.30 A; 3=1-188.
DR PDB; 7A5I; EM; 3.70 A; 33=1-188.
DR PDB; 7A5J; EM; 3.10 A; 3=1-188.
DR PDB; 7A5K; EM; 3.70 A; 33=1-188.
DR PDB; 7L08; EM; 3.49 A; 3=1-188.
DR PDB; 7L20; EM; 3.15 A; 3=1-188.
DR PDB; 7O9K; EM; 3.10 A; 3=1-188.
DR PDB; 7O9M; EM; 2.50 A; 3=1-188.
DR PDB; 7ODR; EM; 2.90 A; 3=1-188.
DR PDB; 7ODS; EM; 3.10 A; 3=1-188.
DR PDB; 7ODT; EM; 3.10 A; 3=1-188.
DR PDB; 7OF0; EM; 2.20 A; 3=1-188.
DR PDB; 7OF2; EM; 2.70 A; 3=1-188.
DR PDB; 7OF3; EM; 2.70 A; 3=1-188.
DR PDB; 7OF4; EM; 2.70 A; 3=1-188.
DR PDB; 7OF5; EM; 2.90 A; 3=1-188.
DR PDB; 7OF6; EM; 2.60 A; 3=1-188.
DR PDB; 7OF7; EM; 2.50 A; 3=1-188.
DR PDB; 7OG4; EM; 3.80 A; 3=1-188.
DR PDB; 7OI7; EM; 3.50 A; 3=1-188.
DR PDB; 7OI8; EM; 3.50 A; 3=1-188.
DR PDB; 7OI9; EM; 3.30 A; 3=1-188.
DR PDB; 7OIA; EM; 3.20 A; 3=1-188.
DR PDB; 7OIB; EM; 3.30 A; 3=1-188.
DR PDB; 7OIC; EM; 3.10 A; 3=1-188.
DR PDB; 7OID; EM; 3.70 A; 3=1-188.
DR PDB; 7OIE; EM; 3.50 A; 3=1-188.
DR PDB; 7PD3; EM; 3.40 A; 3=1-188.
DR PDB; 7QH6; EM; 3.08 A; 3=1-188.
DR PDBsum; 3J7Y; -.
DR PDBsum; 3J9M; -.
DR PDBsum; 5OOL; -.
DR PDBsum; 5OOM; -.
DR PDBsum; 6I9R; -.
DR PDBsum; 6NU2; -.
DR PDBsum; 6NU3; -.
DR PDBsum; 6VLZ; -.
DR PDBsum; 6VMI; -.
DR PDBsum; 6ZM5; -.
DR PDBsum; 6ZM6; -.
DR PDBsum; 6ZS9; -.
DR PDBsum; 6ZSA; -.
DR PDBsum; 6ZSB; -.
DR PDBsum; 6ZSC; -.
DR PDBsum; 6ZSD; -.
DR PDBsum; 6ZSE; -.
DR PDBsum; 6ZSG; -.
DR PDBsum; 7A5F; -.
DR PDBsum; 7A5G; -.
DR PDBsum; 7A5H; -.
DR PDBsum; 7A5I; -.
DR PDBsum; 7A5J; -.
DR PDBsum; 7A5K; -.
DR PDBsum; 7L08; -.
DR PDBsum; 7L20; -.
DR PDBsum; 7O9K; -.
DR PDBsum; 7O9M; -.
DR PDBsum; 7ODR; -.
DR PDBsum; 7ODS; -.
DR PDBsum; 7ODT; -.
DR PDBsum; 7OF0; -.
DR PDBsum; 7OF2; -.
DR PDBsum; 7OF3; -.
DR PDBsum; 7OF4; -.
DR PDBsum; 7OF5; -.
DR PDBsum; 7OF6; -.
DR PDBsum; 7OF7; -.
DR PDBsum; 7OG4; -.
DR PDBsum; 7OI7; -.
DR PDBsum; 7OI8; -.
DR PDBsum; 7OI9; -.
DR PDBsum; 7OIA; -.
DR PDBsum; 7OIB; -.
DR PDBsum; 7OIC; -.
DR PDBsum; 7OID; -.
DR PDBsum; 7OIE; -.
DR PDBsum; 7PD3; -.
DR PDBsum; 7QH6; -.
DR AlphaFoldDB; Q9NZE8; -.
DR SMR; Q9NZE8; -.
DR BioGRID; 119469; 97.
DR ComplexPortal; CPX-5226; 39S mitochondrial large ribosomal subunit.
DR CORUM; Q9NZE8; -.
DR IntAct; Q9NZE8; 52.
DR MINT; Q9NZE8; -.
DR STRING; 9606.ENSP00000338389; -.
DR iPTMnet; Q9NZE8; -.
DR PhosphoSitePlus; Q9NZE8; -.
DR BioMuta; MRPL35; -.
DR EPD; Q9NZE8; -.
DR jPOST; Q9NZE8; -.
DR MassIVE; Q9NZE8; -.
DR MaxQB; Q9NZE8; -.
DR PaxDb; Q9NZE8; -.
DR PeptideAtlas; Q9NZE8; -.
DR PRIDE; Q9NZE8; -.
DR ProteomicsDB; 83381; -. [Q9NZE8-1]
DR ProteomicsDB; 83382; -. [Q9NZE8-2]
DR Antibodypedia; 51696; 43 antibodies from 18 providers.
DR DNASU; 51318; -.
DR Ensembl; ENST00000254644.12; ENSP00000254644.7; ENSG00000132313.15. [Q9NZE8-2]
DR Ensembl; ENST00000337109.9; ENSP00000338389.4; ENSG00000132313.15. [Q9NZE8-1]
DR GeneID; 51318; -.
DR KEGG; hsa:51318; -.
DR MANE-Select; ENST00000337109.9; ENSP00000338389.4; NM_016622.4; NP_057706.2.
DR UCSC; uc002srg.5; human. [Q9NZE8-1]
DR CTD; 51318; -.
DR DisGeNET; 51318; -.
DR GeneCards; MRPL35; -.
DR HGNC; HGNC:14489; MRPL35.
DR HPA; ENSG00000132313; Low tissue specificity.
DR MIM; 611841; gene.
DR neXtProt; NX_Q9NZE8; -.
DR OpenTargets; ENSG00000132313; -.
DR PharmGKB; PA30966; -.
DR VEuPathDB; HostDB:ENSG00000132313; -.
DR eggNOG; KOG4316; Eukaryota.
DR GeneTree; ENSGT00390000007547; -.
DR HOGENOM; CLU_123951_0_0_1; -.
DR InParanoid; Q9NZE8; -.
DR OMA; TYCSTRK; -.
DR OrthoDB; 1333597at2759; -.
DR PhylomeDB; Q9NZE8; -.
DR TreeFam; TF317642; -.
DR PathwayCommons; Q9NZE8; -.
DR Reactome; R-HSA-5368286; Mitochondrial translation initiation.
DR Reactome; R-HSA-5389840; Mitochondrial translation elongation.
DR Reactome; R-HSA-5419276; Mitochondrial translation termination.
DR SignaLink; Q9NZE8; -.
DR SIGNOR; Q9NZE8; -.
DR BioGRID-ORCS; 51318; 387 hits in 1047 CRISPR screens.
DR ChiTaRS; MRPL35; human.
DR GenomeRNAi; 51318; -.
DR Pharos; Q9NZE8; Tdark.
DR PRO; PR:Q9NZE8; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q9NZE8; protein.
DR Bgee; ENSG00000132313; Expressed in rectum and 195 other tissues.
DR ExpressionAtlas; Q9NZE8; baseline and differential.
DR Genevisible; Q9NZE8; HS.
DR GO; GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
DR GO; GO:0005762; C:mitochondrial large ribosomal subunit; IDA:UniProtKB.
DR GO; GO:0005761; C:mitochondrial ribosome; NAS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IDA:UniProtKB.
DR GO; GO:0003735; F:structural constituent of ribosome; NAS:UniProtKB.
DR GO; GO:0032543; P:mitochondrial translation; IC:ComplexPortal.
DR GO; GO:0006412; P:translation; NAS:UniProtKB.
DR Gene3D; 4.10.410.60; -; 1.
DR InterPro; IPR019338; Ribosomal-L35_mit.
DR InterPro; IPR021137; Ribosomal_L35.
DR InterPro; IPR037229; Ribosomal_L35_sf.
DR PANTHER; PTHR15909; PTHR15909; 1.
DR Pfam; PF01632; Ribosomal_L35p; 1.
DR SUPFAM; SSF143034; SSF143034; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Mitochondrion; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein; Transit peptide.
FT TRANSIT 1..?
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN ?..188
FT /note="39S ribosomal protein L35, mitochondrial"
FT /id="PRO_0000030525"
FT VAR_SEQ 171..188
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_036507"
FT VARIANT 19
FT /note="P -> S (in dbSNP:rs10901)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_030010"
FT VARIANT 24
FT /note="A -> T (in dbSNP:rs17851803)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_054632"
FT VARIANT 29
FT /note="R -> H (in dbSNP:rs1051949)"
FT /id="VAR_054633"
FT VARIANT 80
FT /note="A -> P (in dbSNP:rs34044771)"
FT /id="VAR_034463"
FT VARIANT 81
FT /note="P -> L (in dbSNP:rs3192352)"
FT /id="VAR_051803"
FT VARIANT 180
FT /note="Y -> C (in dbSNP:rs1052065)"
FT /id="VAR_054634"
FT TURN 99..101
FT /evidence="ECO:0007829|PDB:7OF0"
FT HELIX 108..111
FT /evidence="ECO:0007829|PDB:7OF0"
FT STRAND 114..116
FT /evidence="ECO:0007829|PDB:3J7Y"
FT TURN 118..120
FT /evidence="ECO:0007829|PDB:7OI8"
FT STRAND 122..124
FT /evidence="ECO:0007829|PDB:7OF0"
FT TURN 127..130
FT /evidence="ECO:0007829|PDB:7OF0"
FT HELIX 133..135
FT /evidence="ECO:0007829|PDB:7OF0"
FT HELIX 138..144
FT /evidence="ECO:0007829|PDB:7OF0"
FT STRAND 145..149
FT /evidence="ECO:0007829|PDB:5OOM"
FT HELIX 152..161
FT /evidence="ECO:0007829|PDB:7OF0"
FT HELIX 164..167
FT /evidence="ECO:0007829|PDB:7OF0"
FT STRAND 172..174
FT /evidence="ECO:0007829|PDB:5OOM"
FT TURN 176..178
FT /evidence="ECO:0007829|PDB:7OF0"
FT HELIX 179..181
FT /evidence="ECO:0007829|PDB:7OF0"
SQ SEQUENCE 188 AA; 21514 MW; 3A44076927C5A54B CRC64;
MAASAFAGAV RAASGILRPL NILASSTYRN CVKNASLISA LSTGRFSHIQ TPVVSSTPRL
TTSERNLTCG HTSVILNRMA PVLPSVLKLP VRSLTYFSAR KGKRKTVKAV IDRFLRLHCG
LWVRRKAGYK KKLWKKTPAR KKRLREFVFC NKTQSKLLDK MTTSFWKRRN WYVDDPYQKY
HDRTNLKV
