RM36_HUMAN
ID RM36_HUMAN Reviewed; 103 AA.
AC Q9P0J6; A4UCS0; B2R4Z2; Q3SWV6; Q9UKL7;
DT 19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=39S ribosomal protein L36, mitochondrial;
DE Short=L36mt;
DE Short=MRP-L36;
DE AltName: Full=BRCA1-interacting protein 1;
DE AltName: Full=Mitochondrial large ribosomal subunit protein bL36m {ECO:0000303|PubMed:25278503};
DE Flags: Precursor;
GN Name=MRPL36; Synonyms=BRIP1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11279069; DOI=10.1074/jbc.m100432200;
RA Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A.,
RA Watanabe K.;
RT "Structural compensation for the deficit of rRNA with proteins in the
RT mammalian mitochondrial ribosome. Systematic analysis of protein components
RT of the large ribosomal subunit from mammalian mitochondria.";
RL J. Biol. Chem. 276:21724-21736(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Wang Q., Zhang H., Greene M.I.;
RT "BRIP1, a candidate for BRCA1-interacting protein.";
RL Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Santana-Roman H., Curiel-Quesada E., Tapia-Ramirez J.;
RT "Searching for interaction partners of the transcription factor REST/NRSF
RT by two-hybrid screening.";
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Adrenal gland;
RX PubMed=10931946; DOI=10.1073/pnas.160270997;
RA Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X.,
RA Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W.,
RA Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M., Zhou J., Xu S.-H., Gu J.,
RA Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z.,
RA Chen M.-D., Chen J.-L.;
RT "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis
RT and full-length cDNA cloning.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Thalamus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8] {ECO:0007744|PDB:3J7Y}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.40 ANGSTROMS), SUBCELLULAR LOCATION,
RP AND SUBUNIT.
RX PubMed=25278503; DOI=10.1126/science.1258026;
RA Brown A., Amunts A., Bai X.C., Sugimoto Y., Edwards P.C., Murshudov G.,
RA Scheres S.H., Ramakrishnan V.;
RT "Structure of the large ribosomal subunit from human mitochondria.";
RL Science 346:718-722(2014).
RN [9] {ECO:0007744|PDB:3J9M}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.50 ANGSTROMS), SUBCELLULAR LOCATION,
RP AND SUBUNIT.
RX PubMed=25838379; DOI=10.1126/science.aaa1193;
RA Amunts A., Brown A., Toots J., Scheres S.H., Ramakrishnan V.;
RT "Ribosome. The structure of the human mitochondrial ribosome.";
RL Science 348:95-98(2015).
CC -!- SUBUNIT: Component of the mitochondrial large ribosomal subunit (mt-
CC LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small
CC (28S) and a large (39S) subunit. The 28S small subunit contains a 12S
CC ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large
CC subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial
CC valine transfer RNA (mt-tRNA(Val)), which plays an integral structural
CC role, and 52 different proteins. bL36m has a zinc binding site.
CC {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379}.
CC -!- INTERACTION:
CC Q9P0J6; Q9UHD4: CIDEB; NbExp=3; IntAct=EBI-2115401, EBI-7062247;
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503,
CC ECO:0000269|PubMed:25838379}.
CC -!- SIMILARITY: Belongs to the bacterial ribosomal protein bL36 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF04788.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB049654; BAB40859.1; -; mRNA.
DR EMBL; AF151109; AAF04788.1; ALT_INIT; mRNA.
DR EMBL; EF036487; ABO65073.1; -; mRNA.
DR EMBL; AF155653; AAF67010.1; -; mRNA.
DR EMBL; AK312001; BAG34939.1; -; mRNA.
DR EMBL; CH471102; EAX08145.1; -; Genomic_DNA.
DR EMBL; BC020642; AAH20642.1; -; mRNA.
DR EMBL; BC104652; AAI04653.1; -; mRNA.
DR CCDS; CCDS3865.1; -.
DR RefSeq; NP_115868.1; NM_032479.3.
DR RefSeq; XP_016865239.1; XM_017009750.1.
DR RefSeq; XP_016865240.1; XM_017009751.1.
DR RefSeq; XP_016865241.1; XM_017009752.1.
DR PDB; 3J7Y; EM; 3.40 A; 4=1-103.
DR PDB; 3J9M; EM; 3.50 A; 4=1-103.
DR PDB; 5OOL; EM; 3.06 A; 4=1-103.
DR PDB; 6I9R; EM; 3.90 A; 4=1-103.
DR PDB; 6NU2; EM; 3.90 A; 4=67-102.
DR PDB; 6NU3; EM; 4.40 A; 4=1-103.
DR PDB; 6VLZ; EM; 2.97 A; 4=1-103.
DR PDB; 6VMI; EM; 2.96 A; 4=1-103.
DR PDB; 6ZM5; EM; 2.89 A; 4=1-103.
DR PDB; 6ZM6; EM; 2.59 A; 4=1-103.
DR PDB; 6ZS9; EM; 4.00 A; 4=1-103.
DR PDB; 6ZSA; EM; 4.00 A; 4=1-103.
DR PDB; 6ZSB; EM; 4.50 A; 4=1-103.
DR PDB; 6ZSC; EM; 3.50 A; 4=1-103.
DR PDB; 6ZSD; EM; 3.70 A; 4=1-103.
DR PDB; 6ZSE; EM; 5.00 A; 4=1-103.
DR PDB; 6ZSG; EM; 4.00 A; 4=1-103.
DR PDB; 7A5F; EM; 4.40 A; 43=1-103.
DR PDB; 7A5G; EM; 4.33 A; 43=1-103.
DR PDB; 7A5I; EM; 3.70 A; 43=1-103.
DR PDB; 7A5J; EM; 3.10 A; 4=1-103.
DR PDB; 7A5K; EM; 3.70 A; 43=1-103.
DR PDB; 7L08; EM; 3.49 A; 4=1-103.
DR PDB; 7L20; EM; 3.15 A; 4=1-103.
DR PDB; 7O9K; EM; 3.10 A; 4=1-103.
DR PDB; 7O9M; EM; 2.50 A; 4=1-103.
DR PDB; 7ODR; EM; 2.90 A; 4=1-103.
DR PDB; 7ODS; EM; 3.10 A; 4=1-103.
DR PDB; 7ODT; EM; 3.10 A; 4=1-103.
DR PDB; 7OF0; EM; 2.20 A; 4=1-103.
DR PDB; 7OF2; EM; 2.70 A; 4=1-103.
DR PDB; 7OF3; EM; 2.70 A; 4=1-103.
DR PDB; 7OF4; EM; 2.70 A; 4=1-103.
DR PDB; 7OF5; EM; 2.90 A; 4=1-103.
DR PDB; 7OF6; EM; 2.60 A; 4=1-103.
DR PDB; 7OF7; EM; 2.50 A; 4=1-103.
DR PDB; 7OG4; EM; 3.80 A; 4=1-103.
DR PDB; 7OIC; EM; 3.10 A; 4=1-103.
DR PDB; 7OID; EM; 3.70 A; 4=1-103.
DR PDB; 7OIE; EM; 3.50 A; 4=1-103.
DR PDB; 7PD3; EM; 3.40 A; 4=1-103.
DR PDBsum; 3J7Y; -.
DR PDBsum; 3J9M; -.
DR PDBsum; 5OOL; -.
DR PDBsum; 6I9R; -.
DR PDBsum; 6NU2; -.
DR PDBsum; 6NU3; -.
DR PDBsum; 6VLZ; -.
DR PDBsum; 6VMI; -.
DR PDBsum; 6ZM5; -.
DR PDBsum; 6ZM6; -.
DR PDBsum; 6ZS9; -.
DR PDBsum; 6ZSA; -.
DR PDBsum; 6ZSB; -.
DR PDBsum; 6ZSC; -.
DR PDBsum; 6ZSD; -.
DR PDBsum; 6ZSE; -.
DR PDBsum; 6ZSG; -.
DR PDBsum; 7A5F; -.
DR PDBsum; 7A5G; -.
DR PDBsum; 7A5I; -.
DR PDBsum; 7A5J; -.
DR PDBsum; 7A5K; -.
DR PDBsum; 7L08; -.
DR PDBsum; 7L20; -.
DR PDBsum; 7O9K; -.
DR PDBsum; 7O9M; -.
DR PDBsum; 7ODR; -.
DR PDBsum; 7ODS; -.
DR PDBsum; 7ODT; -.
DR PDBsum; 7OF0; -.
DR PDBsum; 7OF2; -.
DR PDBsum; 7OF3; -.
DR PDBsum; 7OF4; -.
DR PDBsum; 7OF5; -.
DR PDBsum; 7OF6; -.
DR PDBsum; 7OF7; -.
DR PDBsum; 7OG4; -.
DR PDBsum; 7OIC; -.
DR PDBsum; 7OID; -.
DR PDBsum; 7OIE; -.
DR PDBsum; 7PD3; -.
DR AlphaFoldDB; Q9P0J6; -.
DR SMR; Q9P0J6; -.
DR BioGRID; 122366; 23.
DR ComplexPortal; CPX-5226; 39S mitochondrial large ribosomal subunit.
DR CORUM; Q9P0J6; -.
DR IntAct; Q9P0J6; 6.
DR MINT; Q9P0J6; -.
DR STRING; 9606.ENSP00000423399; -.
DR BioMuta; MRPL36; -.
DR DMDM; 24212267; -.
DR MassIVE; Q9P0J6; -.
DR PaxDb; Q9P0J6; -.
DR PeptideAtlas; Q9P0J6; -.
DR PRIDE; Q9P0J6; -.
DR ProteomicsDB; 83554; -.
DR TopDownProteomics; Q9P0J6; -.
DR Antibodypedia; 22352; 72 antibodies from 21 providers.
DR DNASU; 64979; -.
DR Ensembl; ENST00000382647.7; ENSP00000372093.6; ENSG00000171421.13.
DR Ensembl; ENST00000505059.7; ENSP00000423152.1; ENSG00000171421.13.
DR Ensembl; ENST00000505818.1; ENSP00000427152.1; ENSG00000171421.13.
DR Ensembl; ENST00000508987.1; ENSP00000423399.1; ENSG00000171421.13.
DR GeneID; 64979; -.
DR KEGG; hsa:64979; -.
DR MANE-Select; ENST00000505059.7; ENSP00000423152.1; NM_032479.4; NP_115868.1.
DR UCSC; uc003jcx.5; human.
DR CTD; 64979; -.
DR DisGeNET; 64979; -.
DR GeneCards; MRPL36; -.
DR HGNC; HGNC:14490; MRPL36.
DR HPA; ENSG00000171421; Low tissue specificity.
DR MIM; 611842; gene.
DR neXtProt; NX_Q9P0J6; -.
DR OpenTargets; ENSG00000171421; -.
DR PharmGKB; PA30967; -.
DR VEuPathDB; HostDB:ENSG00000171421; -.
DR eggNOG; KOG4122; Eukaryota.
DR GeneTree; ENSGT00390000010866; -.
DR HOGENOM; CLU_135723_0_0_1; -.
DR InParanoid; Q9P0J6; -.
DR OMA; CTGGPRA; -.
DR OrthoDB; 1640375at2759; -.
DR PhylomeDB; Q9P0J6; -.
DR TreeFam; TF300275; -.
DR PathwayCommons; Q9P0J6; -.
DR Reactome; R-HSA-5368286; Mitochondrial translation initiation.
DR Reactome; R-HSA-5389840; Mitochondrial translation elongation.
DR Reactome; R-HSA-5419276; Mitochondrial translation termination.
DR SignaLink; Q9P0J6; -.
DR SIGNOR; Q9P0J6; -.
DR BioGRID-ORCS; 64979; 454 hits in 1055 CRISPR screens.
DR ChiTaRS; MRPL36; human.
DR GenomeRNAi; 64979; -.
DR Pharos; Q9P0J6; Tbio.
DR PRO; PR:Q9P0J6; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q9P0J6; protein.
DR Bgee; ENSG00000171421; Expressed in pancreatic ductal cell and 188 other tissues.
DR ExpressionAtlas; Q9P0J6; baseline and differential.
DR Genevisible; Q9P0J6; HS.
DR GO; GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
DR GO; GO:0005762; C:mitochondrial large ribosomal subunit; IDA:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IDA:HPA.
DR GO; GO:0016604; C:nuclear body; IDA:HPA.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0032543; P:mitochondrial translation; IC:ComplexPortal.
DR GO; GO:0042254; P:ribosome biogenesis; IBA:GO_Central.
DR GO; GO:0006412; P:translation; NAS:UniProtKB.
DR HAMAP; MF_00251; Ribosomal_L36; 1.
DR InterPro; IPR000473; Ribosomal_L36.
DR InterPro; IPR035977; Ribosomal_L36_sp.
DR Pfam; PF00444; Ribosomal_L36; 1.
DR SUPFAM; SSF57840; SSF57840; 1.
DR TIGRFAMs; TIGR01022; rpmJ_bact; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Mitochondrion; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein; Transit peptide.
FT TRANSIT 1..?
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN ?..103
FT /note="39S ribosomal protein L36, mitochondrial"
FT /id="PRO_0000030529"
FT CONFLICT 36
FT /note="G -> S (in Ref. 2; AAF04788)"
FT /evidence="ECO:0000305"
FT STRAND 76..78
FT /evidence="ECO:0007829|PDB:5OOL"
FT STRAND 79..84
FT /evidence="ECO:0007829|PDB:7OF0"
FT STRAND 87..94
FT /evidence="ECO:0007829|PDB:7OF0"
FT HELIX 96..98
FT /evidence="ECO:0007829|PDB:7OF0"
SQ SEQUENCE 103 AA; 11784 MW; CF1720639DE3C34B CRC64;
MANLFIRKMV NPLLYLSRHT VKPRALSTFL FGSIRGAAPV AVEPGAAVRS LLSPGLLPHL
LPALGFKNKT VLKKRCKDCY LVKRRGRWYV YCKTHPRHKQ RQM
