RM39_DROME
ID RM39_DROME Reviewed; 333 AA.
AC Q9VUJ0; Q8SYN5;
DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 27-JAN-2003, sequence version 2.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=39S ribosomal protein L39, mitochondrial;
DE Short=MRP-L39;
DE AltName: Full=MRP-L5;
GN Name=mRpL39; Synonyms=mRpL5; ORFNames=CG17166;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- SUBUNIT: Component of the mitochondrial ribosome large subunit (39S)
CC which comprises a 16S rRNA and about 50 distinct proteins.
CC {ECO:0000250|UniProtKB:Q9NYK5}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q9NYK5}.
CC -!- SIMILARITY: Belongs to the mitochondrion-specific ribosomal protein
CC mL39 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL49047.1; Type=Frameshift; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE014296; AAF49686.2; -; Genomic_DNA.
DR EMBL; AY071425; AAL49047.1; ALT_FRAME; mRNA.
DR RefSeq; NP_524075.2; NM_079351.4.
DR AlphaFoldDB; Q9VUJ0; -.
DR SMR; Q9VUJ0; -.
DR BioGRID; 64951; 4.
DR DIP; DIP-20391N; -.
DR IntAct; Q9VUJ0; 1.
DR STRING; 7227.FBpp0075425; -.
DR PaxDb; Q9VUJ0; -.
DR PRIDE; Q9VUJ0; -.
DR DNASU; 39627; -.
DR EnsemblMetazoa; FBtr0075672; FBpp0075425; FBgn0036462.
DR GeneID; 39627; -.
DR KEGG; dme:Dmel_CG17166; -.
DR CTD; 54148; -.
DR FlyBase; FBgn0036462; mRpL39.
DR VEuPathDB; VectorBase:FBgn0036462; -.
DR eggNOG; KOG1637; Eukaryota.
DR GeneTree; ENSGT00940000156271; -.
DR HOGENOM; CLU_071313_0_0_1; -.
DR InParanoid; Q9VUJ0; -.
DR OMA; HLKAHHT; -.
DR OrthoDB; 1202682at2759; -.
DR PhylomeDB; Q9VUJ0; -.
DR Reactome; R-DME-5389840; Mitochondrial translation elongation.
DR Reactome; R-DME-5419276; Mitochondrial translation termination.
DR BioGRID-ORCS; 39627; 1 hit in 1 CRISPR screen.
DR GenomeRNAi; 39627; -.
DR PRO; PR:Q9VUJ0; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0036462; Expressed in secondary oocyte and 48 other tissues.
DR ExpressionAtlas; Q9VUJ0; baseline and differential.
DR Genevisible; Q9VUJ0; DM.
DR GO; GO:0005762; C:mitochondrial large ribosomal subunit; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0003735; F:structural constituent of ribosome; TAS:FlyBase.
DR GO; GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.
DR GO; GO:0032543; P:mitochondrial translation; TAS:FlyBase.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR Gene3D; 3.10.20.30; -; 1.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR018163; Thr/Ala-tRNA-synth_IIc_edit.
DR SUPFAM; SSF55186; SSF55186; 1.
DR PROSITE; PS51880; TGS; 1.
PE 2: Evidence at transcript level;
KW Mitochondrion; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW RNA-mediated gene silencing; Translation regulation.
FT CHAIN 1..333
FT /note="39S ribosomal protein L39, mitochondrial"
FT /id="PRO_0000087686"
FT DOMAIN 56..122
FT /note="TGS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01228"
FT REGION 311..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 333 AA; 37324 MW; 27C6515156D35D70 CRC64;
MSAATKLHKT SWCALRQLQQ YRTKANFSGS SASLAKRNDL FNQEQRRQRD AVGRIDKIEV
RYLGLPEDVT LVMNGNISTP FNCAQHLSEG HCKRSALALI DGSVPWDMHR PLQESCTLQL
LNFHVSEPHV VNKAFWRTCS FMLGAALNRA FKPEANLQLH SFPGPNIKSG SFVHDIVLQT
QNWEPGKEEM RALSAEMVKL AAQDLRIERL DVQQDLAQEM FKDSKYKSEQ LPSISQQTNG
RVTLYRLGDH IDISRGPMVA STSFLGKCVI SAAHKVAEEG PSGAFYRIQG VALPSGFQLN
HVAFGVLEER SKKPSPARLP NEPFEEQQQL QLS
