RM40_MOUSE
ID RM40_MOUSE Reviewed; 206 AA.
AC Q9Z2Q5; Q9CS52;
DT 27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 27-MAY-2002, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=39S ribosomal protein L40, mitochondrial;
DE Short=L40mt;
DE Short=MRP-L40;
DE AltName: Full=Nuclear localization signal-containing protein deleted in velocardiofacial syndrome homolog;
DE Flags: Precursor;
GN Name=Mrpl40; Synonyms=Nlvcf;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND VARIANT LYS-200.
RX PubMed=9790763; DOI=10.1006/geno.1998.5488;
RA Funke B., Puech A., Saint-Jore B., Pandita R., Skoultchi A., Morrow B.;
RT "Isolation and characterization of a human gene containing a nuclear
RT localization signal from the critical region for velo-cardio-facial
RT syndrome on 22q11.";
RL Genomics 53:146-154(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 41-206.
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Component of the mitochondrial ribosome large subunit (39S)
CC which comprises a 16S rRNA and about 50 distinct proteins.
CC {ECO:0000250|UniProtKB:Q9NQ50}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q9NQ50}.
CC -!- TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:9790763}.
CC -!- SIMILARITY: Belongs to the mitochondrion-specific ribosomal protein
CC mL40 family. {ECO:0000305}.
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DR EMBL; AF034092; AAC70905.1; -; mRNA.
DR EMBL; BC028436; AAH28436.1; -; mRNA.
DR EMBL; AK018757; BAB31389.1; -; mRNA.
DR CCDS; CCDS28030.1; -.
DR RefSeq; NP_035052.2; NM_010922.2.
DR AlphaFoldDB; Q9Z2Q5; -.
DR SMR; Q9Z2Q5; -.
DR BioGRID; 201786; 22.
DR ComplexPortal; CPX-5302; 39S mitochondrial large ribosomal subunit.
DR STRING; 10090.ENSMUSP00000023391; -.
DR iPTMnet; Q9Z2Q5; -.
DR PhosphoSitePlus; Q9Z2Q5; -.
DR EPD; Q9Z2Q5; -.
DR jPOST; Q9Z2Q5; -.
DR MaxQB; Q9Z2Q5; -.
DR PaxDb; Q9Z2Q5; -.
DR PRIDE; Q9Z2Q5; -.
DR ProteomicsDB; 301604; -.
DR Antibodypedia; 209; 139 antibodies from 24 providers.
DR DNASU; 18100; -.
DR Ensembl; ENSMUST00000023391; ENSMUSP00000023391; ENSMUSG00000022706.
DR GeneID; 18100; -.
DR KEGG; mmu:18100; -.
DR UCSC; uc007yop.2; mouse.
DR CTD; 64976; -.
DR MGI; MGI:1332635; Mrpl40.
DR VEuPathDB; HostDB:ENSMUSG00000022706; -.
DR eggNOG; KOG4778; Eukaryota.
DR GeneTree; ENSGT00390000010239; -.
DR InParanoid; Q9Z2Q5; -.
DR OMA; ATPPIKD; -.
DR OrthoDB; 1524457at2759; -.
DR PhylomeDB; Q9Z2Q5; -.
DR TreeFam; TF105982; -.
DR Reactome; R-MMU-5389840; Mitochondrial translation elongation.
DR Reactome; R-MMU-5419276; Mitochondrial translation termination.
DR BioGRID-ORCS; 18100; 24 hits in 73 CRISPR screens.
DR PRO; PR:Q9Z2Q5; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q9Z2Q5; protein.
DR Bgee; ENSMUSG00000022706; Expressed in morula and 266 other tissues.
DR ExpressionAtlas; Q9Z2Q5; baseline and differential.
DR Genevisible; Q9Z2Q5; MM.
DR GO; GO:0005743; C:mitochondrial inner membrane; IC:ComplexPortal.
DR GO; GO:0005762; C:mitochondrial large ribosomal subunit; ISS:UniProtKB.
DR GO; GO:0005761; C:mitochondrial ribosome; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IDA:MGI.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0032543; P:mitochondrial translation; IC:ComplexPortal.
DR InterPro; IPR039145; MRPL40.
DR InterPro; IPR019192; Ribosomal_L28/L40_mit.
DR PANTHER; PTHR13359; PTHR13359; 1.
DR Pfam; PF09812; MRP-L28; 1.
PE 1: Evidence at protein level;
KW Mitochondrion; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW Transit peptide.
FT TRANSIT 1..46
FT /note="Mitochondrion"
FT /evidence="ECO:0000250"
FT CHAIN 47..206
FT /note="39S ribosomal protein L40, mitochondrial"
FT /id="PRO_0000030559"
FT REGION 170..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 200
FT /note="T -> K"
FT /evidence="ECO:0000269|PubMed:9790763"
SQ SEQUENCE 206 AA; 24301 MW; 9AF9D8095D7B28D2 CRC64;
MATGVMLCAA RALRPRSWIP GTCQAHVRHT HQRASLLAFW DLIPMRAEPL RKKKKVDPRK
DQAAKDRLKK RIRKLEKASQ ELIPIEDFIT PVRFLDKSRQ RPQEEHSPEE SERRALLLKR
WALFKQQEHE MERDAIRSML EAQQEALEEL KLESAELYAE AIKRDTSLFP FEKEGPHYTP
PISNYQAPEG RYNDITKVYT QVEFKR
