RM41_MOUSE
ID RM41_MOUSE Reviewed; 135 AA.
AC Q9CQN7; Q8BJ44;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=39S ribosomal protein L41, mitochondrial;
DE Short=L41mt;
DE Short=MRP-L41;
DE Flags: Precursor;
GN Name=Mrpl41;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Olfactory bulb;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Pancreas, Spleen,
RC and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Component of the mitochondrial ribosome large subunit. Also
CC involved in apoptosis and cell cycle. Enhances p53/TP53 stability,
CC thereby contributing to p53/TP53-induced apoptosis in response to
CC growth-inhibitory condition. Enhances p53/TP53 translocation to the
CC mitochondria. Has the ability to arrest the cell cycle at the G1 phase,
CC possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins.
CC {ECO:0000250|UniProtKB:Q8IXM3}.
CC -!- SUBUNIT: Component of the mitochondrial ribosome large subunit (39S)
CC which comprises a 16S rRNA and about 50 distinct proteins. Interacts
CC with BCL2. {ECO:0000250|UniProtKB:Q8IXM3}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q8IXM3}.
CC -!- SIMILARITY: Belongs to the mitochondrion-specific ribosomal protein
CC mL41 family. {ECO:0000305}.
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DR EMBL; AK003340; BAB22727.1; -; mRNA.
DR EMBL; AK011837; BAB27870.1; -; mRNA.
DR EMBL; AK032370; BAC27838.1; -; mRNA.
DR EMBL; BC034728; AAH34728.1; -; mRNA.
DR CCDS; CCDS15744.1; -.
DR RefSeq; NP_001026978.2; NM_001031808.2.
DR AlphaFoldDB; Q9CQN7; -.
DR SMR; Q9CQN7; -.
DR BioGRID; 223526; 5.
DR ComplexPortal; CPX-5302; 39S mitochondrial large ribosomal subunit.
DR STRING; 10090.ENSMUSP00000043561; -.
DR iPTMnet; Q9CQN7; -.
DR PhosphoSitePlus; Q9CQN7; -.
DR EPD; Q9CQN7; -.
DR MaxQB; Q9CQN7; -.
DR PaxDb; Q9CQN7; -.
DR PeptideAtlas; Q9CQN7; -.
DR PRIDE; Q9CQN7; -.
DR ProteomicsDB; 299860; -.
DR Antibodypedia; 19072; 161 antibodies from 23 providers.
DR DNASU; 107733; -.
DR Ensembl; ENSMUST00000045604; ENSMUSP00000043561; ENSMUSG00000036850.
DR GeneID; 107733; -.
DR KEGG; mmu:107733; -.
DR UCSC; uc008ipu.1; mouse.
DR CTD; 64975; -.
DR MGI; MGI:1333816; Mrpl41.
DR VEuPathDB; HostDB:ENSMUSG00000036850; -.
DR eggNOG; KOG4756; Eukaryota.
DR GeneTree; ENSGT00390000013158; -.
DR HOGENOM; CLU_155983_0_0_1; -.
DR InParanoid; Q9CQN7; -.
DR OMA; RSHNKGR; -.
DR OrthoDB; 1294210at2759; -.
DR PhylomeDB; Q9CQN7; -.
DR TreeFam; TF325007; -.
DR Reactome; R-MMU-5389840; Mitochondrial translation elongation.
DR Reactome; R-MMU-5419276; Mitochondrial translation termination.
DR BioGRID-ORCS; 107733; 22 hits in 77 CRISPR screens.
DR ChiTaRS; Mrpl41; mouse.
DR PRO; PR:Q9CQN7; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q9CQN7; protein.
DR Bgee; ENSMUSG00000036850; Expressed in facial nucleus and 262 other tissues.
DR ExpressionAtlas; Q9CQN7; baseline and differential.
DR Genevisible; Q9CQN7; MM.
DR GO; GO:0005743; C:mitochondrial inner membrane; IC:ComplexPortal.
DR GO; GO:0005762; C:mitochondrial large ribosomal subunit; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:1990904; C:ribonucleoprotein complex; ISS:UniProtKB.
DR GO; GO:0003735; F:structural constituent of ribosome; ISS:UniProtKB.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0032543; P:mitochondrial translation; IC:ComplexPortal.
DR GO; GO:0006412; P:translation; ISS:UniProtKB.
DR InterPro; IPR019189; Ribosomal_L27/L41_mit.
DR PANTHER; PTHR21338; PTHR21338; 1.
DR Pfam; PF09809; MRP-L27; 1.
PE 1: Evidence at protein level;
KW Apoptosis; Cell cycle; Mitochondrion; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein; Transit peptide.
FT TRANSIT 1..13
FT /note="Mitochondrion"
FT /evidence="ECO:0000250"
FT CHAIN 14..135
FT /note="39S ribosomal protein L41, mitochondrial"
FT /id="PRO_0000273229"
FT CONFLICT 76
FT /note="A -> S (in Ref. 1; BAC27838)"
FT /evidence="ECO:0000305"
FT CONFLICT 102
FT /note="F -> I (in Ref. 1; BAC27838)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 135 AA; 15262 MW; 70554E32406EC74E CRC64;
MGFLTAVTQG LVRGADRMSK WTSKRGPRTF TKSRGAKKTG IYTSDRKFVQ IKEMVPEFVV
PDLTGFKLKP YVNYRAPAGI DTPLTAKALF QETVAPAIEK DFKEGTFDAN NLEKYGFEPT
QEGKLFQLYP KNFPR
