ID   RM41_RAT                Reviewed;         134 AA.
AC   Q5BJX1;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=39S ribosomal protein L41, mitochondrial;
DE            Short=L41mt;
DE            Short=MRP-L41;
DE   Flags: Precursor;
GN   Name=Mrpl41;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   PROTEIN SEQUENCE OF 14-29, IDENTIFICATION IN THE 28S MITOCHONDRIAL
RP   RIBOSOME, AND SUBCELLULAR LOCATION.
RX   PubMed=9857009; DOI=10.1074/jbc.273.52.34828;
RA   Goldschmidt-Reisin S., Kitakawa M., Herfurth E., Wittmann-Liebold B.,
RA   Grohmann L., Graack H.-R.;
RT   "Mammalian mitochondrial ribosomal proteins. N-terminal amino acid
RT   sequencing, characterization, and identification of corresponding gene
RT   sequences.";
RL   J. Biol. Chem. 273:34828-34836(1998).
CC   -!- FUNCTION: Component of the mitochondrial ribosome large subunit. Also
CC       involved in apoptosis and cell cycle. Enhances p53/TP53 stability,
CC       thereby contributing to p53/TP53-induced apoptosis in response to
CC       growth-inhibitory condition. Enhances p53/TP53 translocation to the
CC       mitochondria. Has the ability to arrest the cell cycle at the G1 phase,
CC       possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins.
CC       {ECO:0000250|UniProtKB:Q8IXM3}.
CC   -!- SUBUNIT: Component of the mitochondrial ribosome large subunit (39S)
CC       which comprises a 16S rRNA and about 50 distinct proteins. Interacts
CC       with BCL2 (By similarity). Was also identified in the 28S mitochondrial
CC       ribosome (PubMed:9857009). {ECO:0000250|UniProtKB:Q8IXM3,
CC       ECO:0000269|PubMed:9857009}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:9857009}.
CC   -!- SIMILARITY: Belongs to the mitochondrion-specific ribosomal protein
CC       mL41 family. {ECO:0000305}.
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DR   EMBL; BC091293; AAH91293.1; -; mRNA.
DR   RefSeq; NP_001013444.1; NM_001013426.1.
DR   AlphaFoldDB; Q5BJX1; -.
DR   SMR; Q5BJX1; -.
DR   IntAct; Q5BJX1; 1.
DR   STRING; 10116.ENSRNOP00000042070; -.
DR   iPTMnet; Q5BJX1; -.
DR   PhosphoSitePlus; Q5BJX1; -.
DR   jPOST; Q5BJX1; -.
DR   PaxDb; Q5BJX1; -.
DR   PRIDE; Q5BJX1; -.
DR   Ensembl; ENSRNOT00000110175; ENSRNOP00000095947; ENSRNOG00000063489.
DR   GeneID; 296551; -.
DR   KEGG; rno:296551; -.
DR   UCSC; RGD:1310241; rat.
DR   CTD; 64975; -.
DR   RGD; 1310241; Mrpl41.
DR   eggNOG; KOG4756; Eukaryota.
DR   GeneTree; ENSGT00390000013158; -.
DR   HOGENOM; CLU_155983_0_0_1; -.
DR   InParanoid; Q5BJX1; -.
DR   OMA; RSHNKGR; -.
DR   OrthoDB; 1294210at2759; -.
DR   PhylomeDB; Q5BJX1; -.
DR   TreeFam; TF325007; -.
DR   Reactome; R-RNO-5389840; Mitochondrial translation elongation.
DR   Reactome; R-RNO-5419276; Mitochondrial translation termination.
DR   PRO; PR:Q5BJX1; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Bgee; ENSRNOG00000029875; Expressed in heart and 19 other tissues.
DR   Genevisible; Q5BJX1; RN.
DR   GO; GO:0005762; C:mitochondrial large ribosomal subunit; ISS:UniProtKB.
DR   GO; GO:1990904; C:ribonucleoprotein complex; ISS:UniProtKB.
DR   GO; GO:0003735; F:structural constituent of ribosome; ISS:UniProtKB.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0006412; P:translation; ISS:UniProtKB.
DR   InterPro; IPR019189; Ribosomal_L27/L41_mit.
DR   PANTHER; PTHR21338; PTHR21338; 1.
DR   Pfam; PF09809; MRP-L27; 1.
PE   1: Evidence at protein level;
KW   Apoptosis; Cell cycle; Direct protein sequencing; Mitochondrion;
KW   Reference proteome; Ribonucleoprotein; Ribosomal protein; Transit peptide.
FT   TRANSIT         1..13
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000269|PubMed:9857009"
FT   CHAIN           14..134
FT                   /note="39S ribosomal protein L41, mitochondrial"
FT                   /id="PRO_0000273230"
FT   CONFLICT        21
FT                   /note="W -> R (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   134 AA;  15193 MW;  32BA197B37DFB3B4 CRC64;
     MGFLTAVTQG LVRGADRMSK WTSKRGPRTF TKSRGAKKTG FYTNRKFVQI KEMVPEFVVP
     DLTGFKLKPY VNYRAPAGID TPLTAKALFL ETVAPAIEKD FKEGTFDANN LEKYGFEPTQ
     EGKLFQLYPK NFPR